INT70563

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 2.03
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
hepatocyte 3
band 2
plasma 1
liver 1
intestinal epithelium 1
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 8 100.00 Very High Very High Very High
Transcranial magnetic stimulation 126 99.84 Very High Very High Very High
vincristine 2 98.68 Very High Very High Very High
Bioavailability 12 98.44 Very High Very High Very High
methotrexate 4 98.16 Very High Very High Very High
Enkephalin 16 96.96 Very High Very High Very High
methadone 8 96.82 Very High Very High Very High
Gabapentin 1 85.52 High High
Lamotrigine 1 83.28 Quite High
carbamazepine 1 82.00 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 6 99.00 Very High Very High Very High
Diarrhoea 8 93.76 High High
Enterocolitis 2 91.52 High High
Injury 184 89.60 High High
Vomiting 1 81.92 Quite High
Abdominal Pain 1 81.60 Quite High
Fever 1 80.96 Quite High
Renal Failure 2 68.60 Quite High
Cv Unclassified Under Development 3 65.76 Quite High
Gastroenteritis 1 65.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data is in agreement with the literature showing that most compounds secreted by the P-glycoprotein transporter carry a positive charge.
Localization (secreted) of P-glycoprotein
1) Confidence 0.78 Published 1997 Journal J Pharm Sci Section Abstract Doc Link 9232527 Disease Relevance 0 Pain Relevance 0.44
Co-localization of multidrug resistance associated protein 2 (MRP2) and P-gp in SC human hepatocytes was observed on Day 6 in culture.
Localization (localization) of P-gp in hepatocytes
2) Confidence 0.78 Published 2004 Journal Pharm. Res. Section Body Doc Link 15290872 Disease Relevance 0 Pain Relevance 0
These studies examined repolarization, localization of P-glycoprotein (P-gp) to the canalicular domain of the hepatocyte, and re-establishment of vectorial transport in sandwich-cultured (SC) rat and human primary hepatocytes.
Spec (examined) Localization (localization) of P-glycoprotein in hepatocyte
3) Confidence 0.78 Published 2004 Journal Pharm. Res. Section Abstract Doc Link 15290872 Disease Relevance 0 Pain Relevance 0.07
These studies examined repolarization, localization of P-glycoprotein (P-gp) to the canalicular domain of the hepatocyte, and re-establishment of vectorial transport in sandwich-cultured (SC) rat and human primary hepatocytes.
Spec (examined) Localization (localization) of P-gp in hepatocyte
4) Confidence 0.78 Published 2004 Journal Pharm. Res. Section Abstract Doc Link 15290872 Disease Relevance 0 Pain Relevance 0.07
Then each band of the protein representing P-gp from KHOSR2 or U2OSR2 treated with various concentrations of MDR1 siRNA nanoparticles was analyzed for density beyond the background level.
Localization (representing) of MDR1 siRNA in band
5) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
A variety of anti-epileptic drugs (AEDs) were tested for their ability to be transported by P-glycoprotein (P-gp) through Caco-2 monolayers using bi-directional (apical (Ap) to basolateral (Bas), and Bas to Ap) studies.
Localization (transported) of P-glycoprotein in Caco-2 associated with epilepsy
6) Confidence 0.73 Published 2006 Journal J Drug Target Section Abstract Doc Link 16882549 Disease Relevance 0.17 Pain Relevance 0.17
Tacrolimus shows large variability in bioavailability after oral administration, both due to intestinal metabolism by cytochrome P450 (CYP3A4) and active secretion from enterocyte into intestinal lumen by P-glycoprotein.
Localization (secretion) of P-glycoprotein in intestinal lumen associated with bioavailability
7) Confidence 0.68 Published 2004 Journal Transplant. Proc. Section Abstract Doc Link 15518758 Disease Relevance 1.08 Pain Relevance 0.13
For example, the anticancer agent, doxorubicin, does not cross the BBB due to the presence of the P-glycoprotein (P-gp).
Localization (presence) of P-gp
8) Confidence 0.68 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.17 Pain Relevance 0.03
The addition of verapamil equalized the permeabilities in the a-to-b and b-to-a directions, suggesting the involvement of a P-glycoprotein-mediated secretion mechanism.
Localization (secretion) of P-glycoprotein
9) Confidence 0.68 Published 1997 Journal J Pharm Sci Section Abstract Doc Link 9232527 Disease Relevance 0 Pain Relevance 0.51
Absorption of the drug across the intestinal epithelium is complex, involving P-glycoprotein-mediated secretion and saturable binding to intestinal mucus (Langguth et al 1997).
Localization (secretion) of P-glycoprotein in intestinal epithelium
10) Confidence 0.68 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661617 Disease Relevance 0 Pain Relevance 0.27
In contrast to its pharmacokinetics humans, methadone has a short elimination half-life, rapid clearance, and low oral bioavailability in dogs and the extent of absorption is not affected by inhibition of CYP3A, p-gp, and gastric acid secretion.
Localization (secretion) of p-gp associated with methadone and bioavailability
11) Confidence 0.68 Published 2005 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 16207309 Disease Relevance 0 Pain Relevance 0.68
Then each band of the protein representing P-gp from KHOSR2 or U2OSR2 treated with various concentrations of MDR1 siRNA nanoparticles was analyzed for density beyond the background level.
Localization (representing) of P-gp in band
12) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875382 Disease Relevance 0 Pain Relevance 0
These results indicate that YM758 is taken up into hepatocytes mainly via OATP1B1, but not via hOCT1, and is excreted into the bile via MDR1 in humans; however, passive diffusion or an unknown uptake/excretion mechanism could be at work in the hepatocytes.
Localization (excreted) of MDR1 in bile associated with bile
13) Confidence 0.41 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18332079 Disease Relevance 0 Pain Relevance 0.10
The delayed intestinal transit time caused by LPM accounting for an extended plasma-intestine recycling time, and a potential competition between IVM and LPM for the P-GP-mediated bile-intestinal secretion processes, may account for the enhanced IVM systemic availability reported in the current study.
Localization (secretion) of P-GP in plasma associated with bile
14) Confidence 0.28 Published 2004 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 14980002 Disease Relevance 0 Pain Relevance 0.05
Here, we used controlled changes in the stimulation parameters (site, intensity, and angle of stimulation) and repeated longitudinal measurements (same day and one week apart) to evaluate the sensitivity and repeatability of TMS/hd-EEG potentials.


Localization (repeatability) of sensitivity associated with transcranial magnetic stimulation
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2858649 Disease Relevance 0 Pain Relevance 0.25
Considering the role played by P-gp, the implications of reduced P-gp function in the intestines, liver, and kidneys are decreased gastrointestinal secretion, hepatic biliary excretion, and renal tubular secretion of P-gp substrates such as vinblastine, vincristine, methotrexate, digoxin, and grepafloxacin [32,33].


Localization (secretion) of P-gp in liver associated with vincristine and methotrexate
16) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.30 Pain Relevance 0.16
Considering the role played by P-gp, the implications of reduced P-gp function in the intestines, liver, and kidneys are decreased gastrointestinal secretion, hepatic biliary excretion, and renal tubular secretion of P-gp substrates such as vinblastine, vincristine, methotrexate, digoxin, and grepafloxacin [32,33].


Localization (secretion) of P-gp in intestines associated with vincristine and methotrexate
17) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.30 Pain Relevance 0.16

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