INT70566

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Context Info
Confidence 0.20
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.31
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
digestive tract 1
epithelium 1
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 39 100.00 Very High Very High Very High
Inflammation 41 98.76 Very High Very High Very High
headache 1 97.06 Very High Very High Very High
Migraine 1 96.86 Very High Very High Very High
Neuropeptide 1 96.58 Very High Very High Very High
cINOD 1 96.08 Very High Very High Very High
calcitonin gene related peptide 16 84.92 Quite High
burning pain 1 80.40 Quite High
qutenza 10 78.64 Quite High
antagonist 19 73.60 Quite High
Disease Link Frequency Relevance Heat
Esophageal Cancer 1 99.10 Very High Very High Very High
INFLAMMATION 53 98.76 Very High Very High Very High
Pancreatic Cancer 1 97.96 Very High Very High Very High
Migraine Disorders 1 97.06 Very High Very High Very High
Cough 10 94.88 High High
Colitis 1 93.64 High High
Breast Cancer 1 91.68 High High
Ileitis 1 91.44 High High
Clostridium Difficile Infection 1 90.68 High High
Cancer 10 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensory neuropeptide, substance P (SP), is present in human airway nerves, beneath and within the epithelium where the condensed localization of neutral endopeptidase (NEP), the major enzyme degrading SP, is observed.
Protein_catabolism (degrading) of SP in epithelium associated with neuropeptide and substance p
1) Confidence 0.20 Published 1996 Journal Pulm Pharmacol Section Abstract Doc Link 9232670 Disease Relevance 0.56 Pain Relevance 0.40
In the digestive tract most publications have focused on the role of vanilloid receptor in inflammation, with emphasis on stimulation of SP release,22-31 or on a role of endopeptidases in degradation of SP, with a resulting decrease in inflammation.32-34 In the ileum and colon, TRPV1 is thought to be a mediator of inflammation because, in experimental models of colitis induced by dextran sulphate sodium,35,36 or of ileitis induced by Clostridium difficile toxin A28 or anandamide,27 inflammation is attenuated in response to TRPV1 channel blockers35,36 or after genetic deletion of TRPV1.37
Protein_catabolism (degradation) of SP in digestive tract associated with colitis, clostridium difficile infection, inflammation, ileitis and substance p
2) Confidence 0.12 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.41 Pain Relevance 0.78
Tolfenamic acid, a nonsteroidal anti-inflammatory drug approved for the treatment of migraine headaches, has been shown to inhibit pancreatic cancer cell growth in vitro and pancreatic and esophageal tumor growth in vivo by inducting the proteosomal degradation of Sp factors [316-320].
Protein_catabolism (degradation) of Sp associated with inflammation, migraine, pancreatic cancer, cinod, headache and esophageal cancer
3) Confidence 0.06 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 1.35 Pain Relevance 0.29

General Comments

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