INT7057

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1986
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 4.02
Pain Relevance 13.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
granulocytes 1
saphenous vein 1
monocytes 1
internal thoracic artery 1
temporal lobe 1
FAIM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 11 99.82 Very High Very High Very High
narcan 37 99.80 Very High Very High Very High
Buprenorphine 664 99.76 Very High Very High Very High
Opioid 199 99.70 Very High Very High Very High
rapifen 4 99.48 Very High Very High Very High
MU agonist 13 99.32 Very High Very High Very High
antagonist 14 99.28 Very High Very High Very High
Morphine 64 99.26 Very High Very High Very High
mu opioid receptor 25 99.04 Very High Very High Very High
agonist 64 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 7 99.56 Very High Very High Very High
Alcohol Addiction 6 99.42 Very High Very High Very High
Pain 244 97.76 Very High Very High Very High
Convulsion 7 94.04 High High
Bordatella Infection 1 92.84 High High
Opiate Addiction 26 92.60 High High
Cancer 33 91.84 High High
Adhesions 1 91.12 High High
Targeted Disruption 1 87.96 High High
Constipation 7 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alfentanil, an opioid with dominant binding to the mu-receptor was given in graded doses (5-, 10- micrograms/kg) to volunteers.
mu-receptor Binding (binding) of associated with rapifen and opioid
1) Confidence 0.48 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2829001 Disease Relevance 0.10 Pain Relevance 0.68
By variation of the substituents on the aromatic rings and a judicious choice of ring substituents, it is possible to obtain low nanomolar binding to the human mu receptor while maintaining good to excellent mu/delta selectivity.
mu receptor Spec (possible) Binding (binding) of
2) Confidence 0.39 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12502358 Disease Relevance 0 Pain Relevance 0.36
These results together with the X-ray structure obtained suggest that agonist and antagonist activity is initiated by a bimodel binding of the compounds in two different orientations at the mu-receptor site.
mu-receptor site Binding (binding) of associated with antagonist and agonist
3) Confidence 0.38 Published 1986 Journal J. Med. Chem. Section Abstract Doc Link 3007760 Disease Relevance 0 Pain Relevance 0.87
Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.
mu receptor Binding (targeting) of
4) Confidence 0.30 Published 2004 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 15454210 Disease Relevance 0 Pain Relevance 0.10
Unlike morphine, it does not possess the ability to bind to the mu3 receptor, and therefore does not have the ability to influence nitric oxide release as measured amperometrically.
mu3 receptor Binding (bind) of associated with morphine
5) Confidence 0.28 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687094 Disease Relevance 0.17 Pain Relevance 0.51
Patients with temporal lobe epilepsy demonstrate enhanced mu receptor binding in the neocortex of the epileptogenic temporal lobe on PET.
mu receptor Binding (binding) of in temporal lobe associated with epilepsy
6) Confidence 0.24 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1337448 Disease Relevance 0.88 Pain Relevance 0.94
It does not produce persistent binding of the mu receptor, which would prevent the action of other opioids in acute and chronic painful conditions (Walsh et al 1995); as a result other opioids can be used for breakthrough pain in the presence of buprenorphine (Budd and Collett 2003).


mu receptor Binding (binding) of associated with pain, breakthrough pain, opioid and buprenorphine
7) Confidence 0.16 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 0.50 Pain Relevance 2.22
RESULTS: The endomorphins did not release NO from human monocytes, granulocytes, saphenous vein, and internal thoracic artery endothelium and did not displace opiate alkaloid binding to mu 3 receptor.
mu 3 receptor Binding (binding) of in monocytes
8) Confidence 0.13 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10375796 Disease Relevance 0.08 Pain Relevance 0
The high affinity to the mu receptor enables buprenorphine to exert its analgesic effect for a long duration, eliminating the need for daily dosing and overcoming problems of non-adherence to treatment regimens which is common in the elderly.
mu receptor Binding (affinity) of associated with analgesic and buprenorphine
9) Confidence 0.12 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 1.08 Pain Relevance 0.83
Buprenorphine has a high affinity for the mu receptor and a lower intrinsic activity than a full agonist mu opioid receptor agonist (Cleeland et al 1994).
mu receptor Binding (affinity) of associated with mu opioid receptor, agonist and buprenorphine
10) Confidence 0.12 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682375 Disease Relevance 0.27 Pain Relevance 1.72
Incubation with sucrose 0.45 M significantly inhibited ohmefentanyl-induced internalization of the mu receptor.
mu receptor Binding (internalization) of
11) Confidence 0.12 Published 2003 Journal Life Sci. Section Abstract Doc Link 12726892 Disease Relevance 0.09 Pain Relevance 0.69
While buprenorphine’s manner of interacting with the mu receptor gives rise to its most important attributes and advantages in addiction treatment, the medication also has a significant action at a second receptor:
mu receptor Binding (interacting) of associated with addiction and buprenorphine
12) Confidence 0.11 Published 2004 Journal Sci Pract Perspect Section Body Doc Link PMC2851017 Disease Relevance 0.18 Pain Relevance 1.53
The relevance of opioid receptors in human alcoholism is further evidenced by the association of mu receptor polymorphisms with ethanol dependence.
mu receptor Binding (association) of associated with addiction, alcohol addiction and opioid receptor
13) Confidence 0.05 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630722 Disease Relevance 0.35 Pain Relevance 0.82
RESULTS: The endomorphins did not release NO from human monocytes, granulocytes, saphenous vein, and internal thoracic artery endothelium and did not displace opiate alkaloid binding to mu 3 receptor.
mu 3 receptor Binding (binding) of in granulocytes
14) Confidence 0.04 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10375796 Disease Relevance 0.08 Pain Relevance 0
RESULTS: The endomorphins did not release NO from human monocytes, granulocytes, saphenous vein, and internal thoracic artery endothelium and did not displace opiate alkaloid binding to mu 3 receptor.
mu 3 receptor Binding (binding) of in saphenous vein
15) Confidence 0.04 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10375796 Disease Relevance 0.08 Pain Relevance 0
RESULTS: The endomorphins did not release NO from human monocytes, granulocytes, saphenous vein, and internal thoracic artery endothelium and did not displace opiate alkaloid binding to mu 3 receptor.
mu 3 receptor Binding (binding) of in internal thoracic artery
16) Confidence 0.04 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10375796 Disease Relevance 0.08 Pain Relevance 0
Receptor binding and a wide range of pharmacological studies have proposed several mu receptor subtypes, but only one mu opioid receptor (Oprm) gene has been isolated.
mu receptor Binding (binding) of associated with mu opioid receptor
17) Confidence 0.03 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893644 Disease Relevance 0 Pain Relevance 0.50
Replacement of TM II Asp114 with asparagine or glutamic acid increased mu receptor affinity for naloxone.
mu receptor Binding (affinity) of associated with narcan
18) Confidence 0.02 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8051154 Disease Relevance 0.06 Pain Relevance 1.11
Treatment with MTSEA significantly inhibited [3H]diprenorphine binding to 11 of 22 mutants of the rat mu receptor and 9 of 22 mutants of the human delta receptor and 10 of 22 mutants of the human kappa receptor.
mu receptor Binding (binding) of
19) Confidence 0.02 Published 2001 Journal Biochemistry Section Abstract Doc Link 11434771 Disease Relevance 0 Pain Relevance 0.29
The basal and depolarization-induced release of [Gln8]LHRH in the presence and absence of the opiate agonists [D-Ala2,N-Phe4-Gly-ol5]enkephalin (DAGO), which binds selectively to the mu-receptor subtype, and [D-Thr2,L-Leu5] enkephalyl-Thr (DTLET), which binds selectively to the delta-receptor subtype, and of the opiate antagonist naloxone was assessed in tissue obtained from birds at 4, 8, 12, 16, 20, and 24 weeks of age.
mu-receptor Binding (binds) of associated with antagonist, narcan, agonist, enkephalin and opiate
20) Confidence 0.00 Published 1988 Journal Endocrinology Section Abstract Doc Link 3293984 Disease Relevance 0 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox