INT70572

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 33
Total Number 36
Disease Relevance 5.22
Pain Relevance 8.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst) nucleus (Fst) cellular_component (Fst)
cytoplasm (Fst)
Anatomy Link Frequency
pituitary 3
gonadotrophs 2
neuronal 1
plasma 1
striatum 1
Fst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 46 100.00 Very High Very High Very High
fluoxetine 218 99.98 Very High Very High Very High
amygdala 238 99.80 Very High Very High Very High
Desipramine 9 99.68 Very High Very High Very High
cytokine 333 99.48 Very High Very High Very High
antidepressant 136 98.88 Very High Very High Very High
monoamine 51 98.66 Very High Very High Very High
Dopamine 628 98.48 Very High Very High Very High
antagonist 587 97.40 Very High Very High Very High
Neurotransmitter 156 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 306 99.18 Very High Very High Very High
Overactive Bladder 10 97.28 Very High Very High Very High
Stress 771 97.20 Very High Very High Very High
Depression 195 91.12 High High
Adenoma 75 89.92 High High
Attention Deficit Hyperactivity Disorder 15 82.56 Quite High
Sprains And Strains 25 77.88 Quite High
Urological Neuroanatomy 2 75.00 Quite High
Cognitive Disorder 32 74.52 Quite High
Targeted Disruption 336 68.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicated that low doses of desipramine and fluoxetine produced different behavioral patterns in the FST, but only after chronic administration.
Gene_expression (produced) of FST associated with desipramine and fluoxetine
1) Confidence 0.78 Published 1997 Journal Exp Clin Psychopharmacol Section Abstract Doc Link 9234045 Disease Relevance 0.15 Pain Relevance 0.75
The observations that the small METH dose caused further increases in Fst mRNA levels on the lesioned side of 6-OHDA-treated rats suggest that these METH-induced alterations in Fst expression might be independent of METH-induced DA release.
Gene_expression (expression) of Fst associated with dopamine
2) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.28
The qPCR experiment also replicated the array data for Fst expression, which showed significant increases (3.39-fold) on the DA-depleted side of hemiparkinsonian rats (Figure 3F).
Gene_expression (expression) of Fst associated with dopamine
3) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.20
FST, a monomeric glycoprotein which is co-expressed with the activins, irreversibly binds with activins and prevents their interactions with their receptors [67]–[69].
Gene_expression (expressed) of FST
4) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0.18 Pain Relevance 0.32
Therefore, fluoxetine treatment altered adaptation of the regional response of extracellular 5-HT ordinarily produced in the FST, reversing the 5-HT response to the initial swim in the striatum and restoring the response to the initial swim in the lateral septum.
Gene_expression (produced) of FST in striatum associated with fluoxetine
5) Confidence 0.68 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262365 Disease Relevance 0 Pain Relevance 0.54
Up-regulated genes include Ldhc, Stab2, Nmu, Fst, Nts, and Tac2 whereas down-regulated transcripts included Tac1 (Table 2).
Gene_expression (include) of Fst
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.18
Rats were exposed to the FST on the 15th day.
Gene_expression (exposed) of FST
7) Confidence 0.59 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211979 Disease Relevance 0.66 Pain Relevance 0.30
We note that the computation of FST between two sampled populations is equivalent to the above formula for ??
Gene_expression (computation) of FST
8) Confidence 0.57 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2684636 Disease Relevance 0 Pain Relevance 0
High-FST outlier approach
Gene_expression (approach) of FST
9) Confidence 0.54 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2942893 Disease Relevance 0 Pain Relevance 0
After a pre-test session (day 1) of 15 min each rat was dried (under warm air current) and twenty-four hours later exposed again to FST during 5 min.
Gene_expression (exposed) of FST
10) Confidence 0.52 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.15
Thus, injection of vehicle did not alter significantly the effect of FST upon 5-HT levels and Tyr-tub expression.
Gene_expression (expression) of FST
11) Confidence 0.52 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.12
Thus, it is possible that the dPAG participates in the behavioral expression in the FST, inhibiting the passive coping strategies elicited by uncontrollable stress.
Gene_expression (expression) of FST associated with stress
12) Confidence 0.50 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12459505 Disease Relevance 0.49 Pain Relevance 0.37
The average pairwise FST of 0.0026 for the 11 regions we analyzed is similar to FST values between different European populations.
Gene_expression (values) of FST
13) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2684636 Disease Relevance 0 Pain Relevance 0.07
The average pairwise FST of 0.0026 for the 11 regions we analyzed is similar to FST values between different European populations.
Gene_expression (values) of FST
14) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2684636 Disease Relevance 0 Pain Relevance 0.07
Doses of SalvA that produced these effects in the FST did not affect locomotor activity in an open field.
Gene_expression (produced) of FST associated with eae
15) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16223871 Disease Relevance 0.53 Pain Relevance 0.96
Thus, combining certain doses of pharmacologically selective monoamine reuptake inhibitors, or the mixed reuptake inhibitor venlafaxine, produced a pattern of mixed active behaviors in the FST (climbing and swimming) that may reflect the activity of multiple neurotransmitters, especially the combination of enhanced 5-HT and DA activity.
Gene_expression (produced) of FST associated with dopamine, neurotransmitter and monoamine
16) Confidence 0.48 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9551776 Disease Relevance 0 Pain Relevance 1.12
These original parallel electrochemical and western blot results further support such combined methodology as useful concomitant analytical approach indicating that in rats submitted to FST a reduced neuronal plasticity can be detected together with coupled decreased activity of central serotonergic system.
Gene_expression (detected) of FST in neuronal
17) Confidence 0.47 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.08 Pain Relevance 0.08
Furthermore, the significant negative correlation observed between these two measures implies that the most anhedonic animals are the most helpless in the FST.
Gene_expression (helpless) of FST
18) Confidence 0.41 Published 2008 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2634526 Disease Relevance 0.85 Pain Relevance 0.14
In addition, the number of animals in each group was too small to reach statistical power when the rats were divided into HA and LA subgroups (a third of the rats were not used in the FST).


Neg (not) Gene_expression (used) of FST associated with eae and anxiety disorder
19) Confidence 0.33 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.59 Pain Relevance 0.31
In all the following cases a relationship present in the BLA lesion group was notably weaker, if not absent, than in the intact BLA group: (i) a negative influence of fluoxetine in FST immobility; (ii) a positive relationship of BrdU on FST immobility; and (iii) a negative influence of anxiety in Ki67.
Gene_expression (immobility) of FST associated with anxiety disorder, amygdala and fluoxetine
20) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0.46 Pain Relevance 0.70

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