INT7059

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2007
Negated 11
Speculated 12
Reported most in Abstract
Documents 89
Total Number 101
Disease Relevance 18.24
Pain Relevance 48.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
brain 5
spinal 3
hypothalamus 3
plasma 3
brainstem 3
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 250 100.00 Very High Very High Very High
agonist 174 100.00 Very High Very High Very High
antagonist 136 100.00 Very High Very High Very High
noradrenaline 37 100.00 Very High Very High Very High
narcan 21 100.00 Very High Very High Very High
medulla 19 100.00 Very High Very High Very High
Opioid 19 100.00 Very High Very High Very High
Desipramine 19 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 18 100.00 Very High Very High Very High
Shock 10 100.00 Very High Very High Very High
Nervous System Injury 8 100.00 Very High Very High Very High
Nociception 7 99.98 Very High Very High Very High
Convulsion 8 99.96 Very High Very High Very High
Heart Rate Under Development 15 99.84 Very High Very High Very High
Salivary Gland Disease 1 99.84 Very High Very High Very High
Urological Neuroanatomy 19 99.70 Very High Very High Very High
Overactive Bladder 3 99.64 Very High Very High Very High
Pain 7 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha 2 adrenoceptor numbers in the rat hypothalamus were not significantly changed after clorgyline or DMI administration, suggesting that the functional subsensitivity seen in synaptosomes after DMI, may not be related to alpha 2 adrenoceptor down regulation.
Regulation (regulation) of alpha 2 adrenoceptor in hypothalamus
1) Confidence 0.62 Published 1987 Journal Life Sci. Section Abstract Doc Link 3037219 Disease Relevance 0 Pain Relevance 0.35
The results suggest that a single injection of DMI and CMI have not an inhibitory effect on presynaptic alpha 2-adrenergic receptor in the nucleus accumbens.
Neg (not) Regulation (effect) of alpha 2-adrenergic in nucleus accumbens associated with nucleus accumbens and desipramine
2) Confidence 0.62 Published 1995 Journal Seishin Shinkeigaku Zasshi Section Abstract Doc Link 8532817 Disease Relevance 0 Pain Relevance 0.93
Sympathetic and parasympathetic nerves regulate postsynaptic alpha-2 adrenoceptor in salivary glands.
Regulation (regulate) of alpha-2 adrenoceptor in salivary glands associated with salivary gland disease
3) Confidence 0.62 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3021956 Disease Relevance 0.10 Pain Relevance 0.40
The alpha 2-adrenergic receptor regulation of cyclic adenosine monophosphate (cAMP) accumulation in rat brain slices was examined. using a prelabeling technique for measuring second messenger production.
Regulation (regulation) of alpha 2-adrenergic in brain associated with adenocard
4) Confidence 0.58 Published 1986 Journal Brain Res. Section Abstract Doc Link 3022868 Disease Relevance 0 Pain Relevance 0.30
However, the selective alpha 2-adrenoceptor agonist, UK14304, produced a significantly greater inhibition of cyclic AMP accumulation in slices from isolated rats, confirming changes in alpha 2-adrenoceptor function following isolation rearing.
Regulation (changes) of alpha 2-adrenoceptor associated with agonist
5) Confidence 0.45 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862947 Disease Relevance 0.14 Pain Relevance 0.25
The anxiolytic effects of buspirone, its metabolite, 1-(2-pyrimidyl)piperazine (1-PP) and several alpha 2-adrenoceptor antagonists have been compared in an anticonflict (shock-induced suppression of drinking) paradigm in rats.
Regulation (effects) of alpha 2-adrenoceptor associated with antagonist, shock and anxiety disorder
6) Confidence 0.45 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2907485 Disease Relevance 0.27 Pain Relevance 0.35
Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice.
Regulation (effect) of alpha 2 adrenoceptor associated with convulsion and agonist
7) Confidence 0.45 Published 1987 Journal Psychopharmacology (Berl.) Section Title Doc Link 2819922 Disease Relevance 0.26 Pain Relevance 0.55
The potent alpha 2-adrenoceptor antagonist DG5128 did not influence the alpha 2-agonist-induced vasodilation.
Neg (not) Regulation (influence) of alpha 2-adrenoceptor associated with antagonist, agonist and increased venous pressure under development
8) Confidence 0.45 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1974660 Disease Relevance 0.61 Pain Relevance 0.79
The effect of alpha2-adrenoceptor blockade in the medulla was studied in pentobarbital anesthetized rats in which arterial blood pressure, heart rate and renal sympathetic nerve activity were analysed.
Regulation (effect) of alpha2-adrenoceptor in medulla associated with medulla
9) Confidence 0.45 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12398917 Disease Relevance 0 Pain Relevance 0.15
The effects of the alpha2-adrenoceptor antagonist idazoxan on extracellular concentrations of dopamine in major dopaminergic terminal regions in the brain were investigated by means of microdialysis in freely moving rats.
Spec (investigated) Regulation (effects) of alpha2-adrenoceptor in brain associated with dopamine and antagonist
10) Confidence 0.45 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10357252 Disease Relevance 0 Pain Relevance 0.36
Dexmedetomidine decreases the convulsive potency of bupivacaine and levobupivacaine in rats: involvement of alpha2-adrenoceptor for controlling convulsions.
Regulation (controlling) of alpha2-adrenoceptor associated with convulsion and potency
11) Confidence 0.45 Published 2005 Journal Anesth. Analg. Section Title Doc Link 15728053 Disease Relevance 0.29 Pain Relevance 0.33
The effect of a selective alpha2-adrenoceptor antagonist on pain behavior of the rat varies, depending on experimental parameters.
Regulation (effect) of alpha2-adrenoceptor associated with pain and antagonist
12) Confidence 0.45 Published 1998 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 9476998 Disease Relevance 0.24 Pain Relevance 0.66
Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation.
Spec (examined) Regulation (Effects) of alpha2-adrenoceptor associated with antinociception, inflammation, antagonist and narcan
13) Confidence 0.45 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652330 Disease Relevance 0.24 Pain Relevance 0.73
The latter results indicate that the alpha2-adrenergic autoreceptor and heteroreceptor were unaffected in the raphe area by milnacipran.
Neg (unaffected) Regulation (unaffected) of alpha2-adrenergic associated with raphe
14) Confidence 0.45 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9776386 Disease Relevance 0 Pain Relevance 0.34
There is a quantitative reliance on spinal cholinergic neurons in the allodynia relieving properties of intrathecal clonidine, and this reliance does not depend on alpha2-adrenergic receptors colocalized on spinal cholinergic interneurons.


Neg (not) Regulation (depend) of alpha2-adrenergic in interneurons
15) Confidence 0.45 Published 2001 Journal Anesthesiology Section Body Doc Link 11465600 Disease Relevance 0.05 Pain Relevance 0
The modulatory effect of alpha 2 adrenoceptor on the taurine response was investigated in substantia nigra (SN) neurons acutely dissociated from the rat using a nystatin perforated-patch recording mode under voltage-clamp conditions. 2.
Regulation (effect) of alpha 2 adrenoceptor in substantia nigra associated with substantia nigra
16) Confidence 0.45 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0 Pain Relevance 0.17
The treatment of SN neurons with pertussis toxin (500 ng/ ml) for 18 h completely abolished the facilitatory effect of alpha 2 adrenoceptor on Itau. 9.
Regulation (effect) of alpha 2 adrenoceptor in neurons associated with bordatella infection and substantia nigra
17) Confidence 0.45 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0.10 Pain Relevance 0.12
Anxiolytic-like effects of alpha-2-adrenoceptor agonists on conflict behavior in the rat: pre- versus postsynaptic receptor mechanisms.
Regulation (effects) of alpha-2-adrenoceptor associated with anxiety disorder and agonist
18) Confidence 0.43 Published 1992 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 1360159 Disease Relevance 0.25 Pain Relevance 0.37
Although a modulation of dopamine release may be involved in some of these drug effects, the effects on apomorphine-induced circling indicate an influence of alpha-2 adrenoceptor compounds on nigrostriatal neurotransmission at sites downstream from the dopaminergic neurons themselves.
Regulation (influence) of alpha-2 adrenoceptor in dopaminergic neurons associated with dopamine
19) Confidence 0.43 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918591 Disease Relevance 0 Pain Relevance 0.39
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Regulation (Effects) of alpha-2 adrenoceptor associated with antagonist and agonist
20) Confidence 0.43 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9918591 Disease Relevance 0 Pain Relevance 0.35

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