INT70596

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.87
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cytosol (Uchl1)
Anatomy Link Frequency
spinal 1
intermediary 1
nerve 1
brain 1
uterine 1
Uchl1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 42 99.84 Very High Very High Very High
Dismenorea 5 99.70 Very High Very High Very High
Glutamate 22 99.48 Very High Very High Very High
endometriosis 6 99.36 Very High Very High Very High
Gabapentin 8 98.26 Very High Very High Very High
Pain 7 97.46 Very High Very High Very High
Neurotransmitter 10 94.88 High High
Lasting pain 1 81.64 Quite High
Stimulus evoked pain 1 80.96 Quite High
Spinal cord 16 75.00 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 21 100.00 Very High Very High Very High
Dysmenorrhea 5 99.70 Very High Very High Very High
Endometriosis (extended) 6 99.36 Very High Very High Very High
Uterine Fibroids 3 99.00 Very High Very High Very High
Disease 38 98.72 Very High Very High Very High
Targeted Disruption 13 98.62 Very High Very High Very High
Pain 9 97.46 Very High Very High Very High
Motor Neuron Diseases 107 88.48 High High
Neurodegenerative Disease 10 87.68 High High
Hypersensitivity 3 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrated PGP9.5-immunoactive nerve fibers in the functional layer of endometrium in women with pain symptoms, but not in women without pain symptoms, whether the women had endometriosis, adenomyosis, uterine fibroids, or endometriosis with adenomyosis, suggesting a role of PGP9.5-immunoactive nerve fibers in the functional layer of the endometrium playing in pain generation in these disorders.
Regulation (role) of PGP9.5-immunoactive in uterine associated with endometriosis, pain, uterine fibroids and dismenorea
1) Confidence 0.39 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 19535047 Disease Relevance 1.56 Pain Relevance 1.06
Single dose GBP increased brain GABA-T activity and glutamine concentration but was without effect on GAD activity or the concentrations of GABA and glutamate.
Regulation (concentrations) of GAD in brain associated with glutamate, gaba, generalized anxiety disorder and gabapentin
2) Confidence 0.20 Published 1997 Journal Epilepsy Res. Section Abstract Doc Link 9237051 Disease Relevance 0.28 Pain Relevance 1.19
A point mutation affecting the ligase activity of UCHL1 has been linked to Parkinson's disease [46], while an internal 42-amino-acid deletion in UCHL1 is responsible for murine gracile axonal dystrophy, which is characterized by axonal degeneration and formation of spheroid bodies in nerve terminals [47].
Regulation (affecting) of UCHL1 in nerve associated with disease
3) Confidence 0.20 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.62 Pain Relevance 0.03
Both isoforms of GAD are also involved in intermediary metabolism, participating in the GABA shunt, which bypasses two steps of the TCA cycle [21].
Regulation (involved) of GAD in intermediary associated with gaba and generalized anxiety disorder
4) Confidence 0.14 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.83 Pain Relevance 0.43
To address this, we studied inhibitory synaptic transmission in lamina II inhibitory interneurons identified under visual guidance in spinal slices taken from transgenic mice expressing enhanced green fluorescent protein (EGFP) under the control of the GAD promoter.
Regulation (control) of GAD promoter in spinal associated with targeted disruption and generalized anxiety disorder
5) Confidence 0.01 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2689203 Disease Relevance 0.58 Pain Relevance 0.41

General Comments

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