INT70602

Context Info Confidence 0.13 First Reported 1997 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.51 Pain Relevance 1.06

Golgi apparatus (Phex) endoplasmic reticulum (Phex)

Anatomy Link Frequency brain 1 fibroblast 1 Phex (Rattus norvegicus)

Pain Link Frequency Relevance Heat opiate 5 99.92 Dynorphin 10 99.84 Enkephalin 5 91.52 Pain 1 86.68 Morphine 1 84.16 narcan 2 75.28 cerebral cortex 1 75.00 cINOD 4 50.00 Potency 1 48.08 Kappa opioid receptor 1 27.92

Disease Link Frequency Relevance Heat Cancer 2 93.76 Autosomal Disorder 1 91.88 Rickets 6 90.60 Neurilemmoma 2 89.88 Malignant Neoplastic Disease 2 89.44 Muscle Weakness 1 87.88 Fatigue 1 87.04 Pain 1 86.68 Hypophosphatemia 1 82.68 Paraneoplastic Syndromes 1 80.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.

Regulation (phosphate-regulating) of PHEX in fibroblast associated with autosomal disorder and rickets

1) Confidence 0.13 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.43 Pain Relevance 0.09

Rat brain cortical cells in primary culture were used to investigate long-term effects of opiates on endopeptidases acting on dynorphin peptides.

Regulation (acting) of endopeptidases in brain associated with dynorphin and opiate

2) Confidence 0.02 Published 1997 Journal Brain Res. Section Abstract Doc Link 9237522 Disease Relevance 0 Pain Relevance 0.98

In other systems, TNFalpha-induced apoptosis is mediated by caspases, a growing family of cysteine proteases similar to the IL-1beta converting enzyme (ICE), and so we have investigated whether NO-NSAIDs modulate ICE-like endopeptidases.

Regulation (modulate) of endopeptidases

3) Confidence 0.00 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10102977 Disease Relevance 0.08 Pain Relevance 0

General Comments

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