INT70602

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Context Info
Confidence 0.13
First Reported 1997
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.51
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Phex) endoplasmic reticulum (Phex)
Anatomy Link Frequency
brain 1
fibroblast 1
Phex (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 5 99.92 Very High Very High Very High
Dynorphin 10 99.84 Very High Very High Very High
Enkephalin 5 91.52 High High
Pain 1 86.68 High High
Morphine 1 84.16 Quite High
narcan 2 75.28 Quite High
cerebral cortex 1 75.00 Quite High
cINOD 4 50.00 Quite Low
Potency 1 48.08 Quite Low
Kappa opioid receptor 1 27.92 Quite Low
Disease Link Frequency Relevance Heat
Cancer 2 93.76 High High
Autosomal Disorder 1 91.88 High High
Rickets 6 90.60 High High
Neurilemmoma 2 89.88 High High
Malignant Neoplastic Disease 2 89.44 High High
Muscle Weakness 1 87.88 High High
Fatigue 1 87.04 High High
Pain 1 86.68 High High
Hypophosphatemia 1 82.68 Quite High
Paraneoplastic Syndromes 1 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cell line did express PHEX (phosphate-regulating gene with homologies to endopeptidases located on the X-chromosome) and FGF-23 (fibroblast growth factor-23) transcripts on northern hybridization; however, none of the known mutations from the related mendelian disorders of X-linked hypophosphatemic rickets or autosomal-dominant hypophosphatemic rickets could be detected.
Regulation (phosphate-regulating) of PHEX in fibroblast associated with autosomal disorder and rickets
1) Confidence 0.13 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.43 Pain Relevance 0.09
Rat brain cortical cells in primary culture were used to investigate long-term effects of opiates on endopeptidases acting on dynorphin peptides.
Regulation (acting) of endopeptidases in brain associated with dynorphin and opiate
2) Confidence 0.02 Published 1997 Journal Brain Res. Section Abstract Doc Link 9237522 Disease Relevance 0 Pain Relevance 0.98
In other systems, TNFalpha-induced apoptosis is mediated by caspases, a growing family of cysteine proteases similar to the IL-1beta converting enzyme (ICE), and so we have investigated whether NO-NSAIDs modulate ICE-like endopeptidases.
Regulation (modulate) of endopeptidases
3) Confidence 0.00 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10102977 Disease Relevance 0.08 Pain Relevance 0

General Comments

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