INT70604

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
neurons 2
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 98.22 Very High Very High Very High
Action potential 2 92.56 High High
fortral 5 89.28 High High
Potency 1 88.36 High High
potassium channel 2 80.56 Quite High
Neuropeptide 2 75.00 Quite High
Dopamine 2 75.00 Quite High
agonist 1 74.52 Quite High
Analgesic 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preincubation of neurons with the irreversible sigma receptor antagonist metaphit blocked DTG-induced inhibition of K(+) channels, confirming that the effect is mediated by sigma receptor activation.
Positive_regulation (mediated) of Positive_regulation (activation) of sigma receptor in neurons associated with antagonist
1) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15764734 Disease Relevance 0 Pain Relevance 0.34
Our findings are consistent with the potential role of NPY as an endogenous ligand for a subtype of sigma receptor with characteristics different from Y1, Y2 and Y3 receptors but sensitive to PYX-1.
Positive_regulation (role) of Positive_regulation (subtype) of sigma receptor
2) Confidence 0.11 Published 1997 Journal Brain Res. Section Abstract Doc Link 9237537 Disease Relevance 0 Pain Relevance 0.64

General Comments

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