INT70613

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Context Info
Confidence 0.59
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 38.91
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
SH-SY5Y 4
endometrium 4
chondrocytes 2
lymph nodes 2
SW480 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 12 100.00 Very High Very High Very High
Dynorphin 10 99.48 Very High Very High Very High
Morphine 21 99.28 Very High Very High Very High
isoflurane 6 99.06 Very High Very High Very High
endometriosis 59 98.40 Very High Very High Very High
local anesthetic 1 97.40 Very High Very High Very High
Endogenous opioid 2 94.16 High High
dexamethasone 25 90.32 High High
cytokine 69 87.20 High High
Antinociceptive 2 86.24 High High
Disease Link Frequency Relevance Heat
Apoptosis 1254 100.00 Very High Very High Very High
Endometriosis 80 100.00 Very High Very High Very High
Repression 12 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 9 100.00 Very High Very High Very High
Metastasis 142 99.90 Very High Very High Very High
Stomach Cancer 54 99.84 Very High Very High Very High
Renal Cancer 63 99.76 Very High Very High Very High
Cancer 1170 99.70 Very High Very High Very High
Breast Cancer 165 99.68 Very High Very High Very High
Disease 94 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: After 16 h of dynorphin (10 microM) treatment, the SH-SY5Y cells showed significant cytotoxicity, apoptosis, and downregulation of the antiapoptotic Bcl-2 protein expression.
Negative_regulation (downregulation) of Gene_expression (expression) of Bcl-2 in SH-SY5Y
1) Confidence 0.59 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19032555 Disease Relevance 0.07 Pain Relevance 0
By using Western blotting methods, capsaicin reduced the expression of Bcl-2, the antiapoptotic protein, in AGS cells in a concentration-dependent manner.
Negative_regulation (reduced) of Gene_expression (expression) of Bcl-2 in AGS
2) Confidence 0.59 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 16419151 Disease Relevance 0.18 Pain Relevance 0
Down-regulation of Bcl2 expression might represent a potential mechanism by which ASA induces apoptosis in this COX-2 negative colon cancer cell line.
Negative_regulation (regulation) of Gene_expression (expression) of Bcl2 in colon
3) Confidence 0.53 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12423325 Disease Relevance 0.11 Pain Relevance 0
In addition, BV induces apoptosis in rheumatoid synovial cells through a decrease in BCL2 expression and an increase in BAX and caspase-3 (CASP3) expression.
Negative_regulation (decrease) of Gene_expression (expression) of BCL2 in synovial cells associated with apoptosis
4) Confidence 0.52 Published 2005 Journal Toxicon Section Abstract Doc Link 15922390 Disease Relevance 1.05 Pain Relevance 0.28
Morphine-treated Jurkat cells also showed a decreased expression of bcl-2 and an enhanced expression of bax.
Negative_regulation (decreased) of Gene_expression (expression) of bcl-2 associated with morphine
5) Confidence 0.50 Published 1999 Journal J. Leukoc. Biol. Section Abstract Doc Link 10534122 Disease Relevance 0.95 Pain Relevance 0.87
Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells.
Negative_regulation (downregulation) of Gene_expression (expression) of Bcl-2 in SH-SY5Y associated with neuroblastoma, dynorphin and isoflurane
6) Confidence 0.43 Published 2009 Journal Acta Anaesthesiol Scand Section Title Doc Link 19032555 Disease Relevance 0.10 Pain Relevance 0.46
In contrast, stromal bcl-2 expression in adenomyosis remained at low levels and did not show significant cyclical variation.
Negative_regulation (remained) of Gene_expression (expression) of bcl-2 associated with dismenorea
7) Confidence 0.43 Published 1998 Journal Hum. Reprod. Section Abstract Doc Link 9886539 Disease Relevance 1.07 Pain Relevance 0.35
It has been shown that the treatment of melanoma cells with oligonucleotides targeting the reduction of bcl-2 expression rendered those cells more sensitive to chemotherapy [5,36-41].
Negative_regulation (reduction) of Gene_expression (expression) of bcl-2 associated with melanoma
8) Confidence 0.42 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.62 Pain Relevance 0
In some types of neoplasms originating from these tissues (such as lymph nodes with breast cancer metastasis), a relationship between bcl-2 expression and longer disease-free survival has been observed.
Negative_regulation (relationship) of Gene_expression (expression) of bcl-2 in lymph nodes associated with cancer, breast cancer, disease and metastasis
9) Confidence 0.42 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.92 Pain Relevance 0
CONCLUSIONS: Our results suggest that the pathogenesis of ovarian endometriosis may be different from that of adenomyosis and the persistence of Bcl-2 and Bax expressions during both phases of the cycle in ovarian endometriotic tissues may have important implications for the survival and proliferation of the ectopic endometrial tissue.


Negative_regulation (persistence) of Gene_expression (expressions) of Bcl-2
10) Confidence 0.42 Published 2001 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Body Doc Link 11788183 Disease Relevance 0 Pain Relevance 0
Loss of bcl-2 gene expression has been linked to poor patient prognosis.
Negative_regulation (Loss) of Gene_expression (expression) of bcl-2
11) Confidence 0.41 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 0.89 Pain Relevance 0
The expression of bcl-2 in the eutopic endometrial and adenomyotic tissues was limited to the proliferative phase, and was observed in only one of the 12 cases of ovarian endometriosis.
Negative_regulation (observed) of Gene_expression (expression) of bcl-2 associated with endometriosis and dismenorea
12) Confidence 0.39 Published 1996 Journal Mol. Hum. Reprod. Section Abstract Doc Link 9238697 Disease Relevance 1.50 Pain Relevance 0.51
After treatment with ASA, down-regulation of Bcl2 and CD44v6 expression and up-regulation of nm23 expression were observed in SW480 cells.
Negative_regulation (down-regulation) of Gene_expression (expression) of Bcl2 in SW480
13) Confidence 0.39 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12423325 Disease Relevance 0.13 Pain Relevance 0
Furthermore, Ferrer and colleagues (2009) [38] reported a decreased expression of bcl-2 after intense exercise versus the expression obtained previous exercise.
Negative_regulation (decreased) of Gene_expression (expression) of bcl-2
14) Confidence 0.39 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.45 Pain Relevance 0
Western blot analysis demonstrated that codeinone enhanced the Pro-apoptotic Bax protein expression, but reduced the anti-apoptotic Bcl-2 protein expression.
Negative_regulation (reduced) of Gene_expression (expression) of Bcl-2 associated with apoptosis
15) Confidence 0.36 Published 2003 Journal Anticancer Res. Section Abstract Doc Link 12894543 Disease Relevance 1.00 Pain Relevance 0.25
Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine.
Negative_regulation (decreases) of Gene_expression (expression) of Bcl-2 associated with disorder of lipid metabolism
16) Confidence 0.34 Published 2004 Journal Cell Res. Section Title Doc Link 15538973 Disease Relevance 0.61 Pain Relevance 0.10
Here, we hypothesized that up-regulation of miR-34a via DROSHA deregulation causes repression of BCL2 protein expression, thus contributing to the initiation of apoptotic sensitivity in Par-4-overexpressing cells.
Negative_regulation (repression) of Gene_expression (expression) of BCL2 associated with repression and apoptosis
17) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.75 Pain Relevance 0
These results suggest that up-regulated miR-34a is involved in both the repression of BCL2 protein expression and increased 5-FU sensitivity in Par-4-overexpressing cells.


Negative_regulation (repression) of Gene_expression (expression) of BCL2 associated with repression
18) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.72 Pain Relevance 0
Significantly increased oestrogen receptor expression, bcl-2 expression and numbers of CD8+ leukocytes were found in ectopic compared with eutopic endometrium in endometriosis, and CD56+ endometrial granulated lymphocytes (eGLs) were significantly reduced in ectopic endometrium.
Negative_regulation (numbers) of Gene_expression (expression) of bcl-2 in endometrium associated with endometriosis
19) Confidence 0.32 Published 1998 Journal Hum. Reprod. Update Section Abstract Doc Link 10027623 Disease Relevance 0.77 Pain Relevance 0.38
Treatment with amygdalin increased expression of Bax, a pro-apoptotic protein, decreased expression of Bcl-2, an anti-apoptotic protein, and increased caspase-3 enzyme activity in DU145 and LNCaP prostate cancer cells.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-2 associated with prostate cancer and apoptosis
20) Confidence 0.32 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880611 Disease Relevance 1.68 Pain Relevance 0.07

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