INT70616

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Context Info
Confidence 0.17
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.43

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LOC689539 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 5 92.64 High High
Potency 1 89.16 High High
Disease Link Frequency Relevance Heat
Porphyria 3 96.88 Very High Very High Very High
Hepatic Porphyrias 4 95.08 Very High Very High Very High
Hypertension 1 85.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or allyl-isopropyl-acetamide (AIA) induces hepatic delta-aminolaevulinic acid synthase (ALA-S) and increases the urinary excretion of porphyrin precursors (ALA and PBG) comparable to the latent phase of acute hepatic porphyrias in humans.
Positive_regulation (induces) of delta-aminolaevulinic acid synthase associated with porphyria and hepatic porphyrias
1) Confidence 0.17 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9239451 Disease Relevance 0.60 Pain Relevance 0.43

General Comments

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