INT70622

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Context Info
Confidence 0.04
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 14.90
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
blood 1
fat 1
heart 1
Hypism (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 13 94.00 High High
Central nervous system 11 91.92 High High
Opioid 1 82.80 Quite High
agonist 16 81.40 Quite High
tolerance 15 70.60 Quite High
cytokine 65 67.28 Quite High
alcohol 7 43.84 Quite Low
abdominal pain 1 42.80 Quite Low
colic 2 39.36 Quite Low
Inflammation 107 35.92 Quite Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 40 100.00 Very High Very High Very High
Cognitive Disorder 6 99.92 Very High Very High Very High
Insulin Resistance 146 99.90 Very High Very High Very High
Coronary Artery Disease 47 99.76 Very High Very High Very High
Hyperphagia 14 99.76 Very High Very High Very High
Prediabetic State 74 99.44 Very High Very High Very High
Polycystic Ovary Syndrome 11 99.40 Very High Very High Very High
Diabetes Mellitus 396 98.88 Very High Very High Very High
Disease 90 98.76 Very High Very High Very High
Cardiovascular Disease 73 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and memory impairment is associated with hyperinsulinemia, and insulin
hyperinsulinemia Binding (associated) of associated with cognitive disorder and hyperinsulinism
1) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2465016 Disease Relevance 1.39 Pain Relevance 0.09
Obesity, particularly the abdominal phenotype, may be partly responsible for insulin resistance and associated hyperinsulinemia in women with PCOS.
hyperinsulinemia Binding (associated) of associated with polycystic ovary syndrome, hyperinsulinism, metabolic syndrome and insulin resistance
2) Confidence 0.03 Published 2002 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 12080440 Disease Relevance 2.23 Pain Relevance 0.08
Insulin resistance rather than hyperinsulinemia is more closely associated with blood pressure.
hyperinsulinemia Binding (associated) of in blood associated with hyperinsulinism and insulin resistance
3) Confidence 0.03 Published 1996 Journal Hypertens. Res. Section Abstract Doc Link 9240771 Disease Relevance 2.90 Pain Relevance 0.27
These same adverse environmental conditions associated with hyperinsulinemia and insulin resistance lead to the development in adult life of the dysmetabolic syndrome, consisting of abdominal obesity, impaired fasting glucose, high triglyceride levels, low high-density lipoprotein levels and hypertension.
hyperinsulinemia Binding (associated) of associated with syndrome, cv unclassified under development, metabolic syndrome, hyperinsulinism and insulin resistance
4) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.76 Pain Relevance 0.03
Endogenous Hyperinsulinemia (eHI) is associated with MR, IR, PD, and early T2DM.
Hyperinsulinemia Binding (associated) of associated with diabetes mellitus, prediabetic state, hyperinsulinism and insulin resistance
5) Confidence 0.02 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.95 Pain Relevance 0.03
Thus, hyperinsulinemia can be linked back to the section "(A).
hyperinsulinemia Binding (linked) of associated with hyperinsulinism
6) Confidence 0.02 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.76 Pain Relevance 0.04
Significant insulin resistance and hyperinsulinemia has been observed to be associated with coronary heart disease in epidemiological studies, particularly so in Asian Indians.
hyperinsulinemia Binding (associated) of in heart associated with coronary artery disease, hyperinsulinism and insulin resistance
7) Confidence 0.01 Published 2000 Journal Indian Heart J Section Abstract Doc Link 10976147 Disease Relevance 1.08 Pain Relevance 0.06
Many cross-sectional epidemiologic studies also demonstrated positive association between intake of saturated fat and hyperinsulinemia, after adjustment for measure of body fat [56, 57], but at least one large, well-designed study showed no association [58].
hyperinsulinemia Binding (association) of in fat associated with hyperinsulinism
8) Confidence 0.01 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.41 Pain Relevance 0
Impaired fetal growth by 30% caloric restriction throughout gestation has also been described to be associated with hyperinsulinemia and hyperleptinemia in adult male offspring [9].
hyperinsulinemia Binding (associated) of associated with hyperinsulinism
9) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.77 Pain Relevance 0
Although increased plasma insulin levels should be associated with reduction in appetite [18], the hyperinsulinemia seen in CR animals, associated with hyperphagia, is likely to reflect reduced central insulin action.
hyperinsulinemia Binding (associated) of in plasma associated with hyperphagia and hyperinsulinism
10) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.57 Pain Relevance 0

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