INT70622

Context Info Confidence 0.04 First Reported 1996 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 10 Disease Relevance 14.90 Pain Relevance 0.59

Anatomy Link Frequency plasma 1 blood 1 fat 1 heart 1 Hypism (Mus musculus)

Pain Link Frequency Relevance Heat Angina 13 94.00 Central nervous system 11 91.92 Opioid 1 82.80 agonist 16 81.40 tolerance 15 70.60 cytokine 65 67.28 alcohol 7 43.84 abdominal pain 1 42.80 colic 2 39.36 Inflammation 107 35.92

Disease Link Frequency Relevance Heat Hyperinsulinism 40 100.00 Cognitive Disorder 6 99.92 Insulin Resistance 146 99.90 Coronary Artery Disease 47 99.76 Hyperphagia 14 99.76 Prediabetic State 74 99.44 Polycystic Ovary Syndrome 11 99.40 Diabetes Mellitus 396 98.88 Disease 90 98.76 Cardiovascular Disease 73 98.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

and memory impairment is associated with hyperinsulinemia, and insulin

hyperinsulinemia Binding (associated) of associated with cognitive disorder and hyperinsulinism

1) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2465016 Disease Relevance 1.39 Pain Relevance 0.09

Obesity, particularly the abdominal phenotype, may be partly responsible for insulin resistance and associated hyperinsulinemia in women with PCOS.

hyperinsulinemia Binding (associated) of associated with polycystic ovary syndrome, hyperinsulinism, metabolic syndrome and insulin resistance

2) Confidence 0.03 Published 2002 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 12080440 Disease Relevance 2.23 Pain Relevance 0.08

Insulin resistance rather than hyperinsulinemia is more closely associated with blood pressure.

hyperinsulinemia Binding (associated) of in blood associated with hyperinsulinism and insulin resistance

3) Confidence 0.03 Published 1996 Journal Hypertens. Res. Section Abstract Doc Link 9240771 Disease Relevance 2.90 Pain Relevance 0.27

These same adverse environmental conditions associated with hyperinsulinemia and insulin resistance lead to the development in adult life of the dysmetabolic syndrome, consisting of abdominal obesity, impaired fasting glucose, high triglyceride levels, low high-density lipoprotein levels and hypertension.

hyperinsulinemia Binding (associated) of associated with syndrome, cv unclassified under development, metabolic syndrome, hyperinsulinism and insulin resistance

4) Confidence 0.03 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 1.76 Pain Relevance 0.03

Endogenous Hyperinsulinemia (eHI) is associated with MR, IR, PD, and early T2DM.

Hyperinsulinemia Binding (associated) of associated with diabetes mellitus, prediabetic state, hyperinsulinism and insulin resistance

5) Confidence 0.02 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.95 Pain Relevance 0.03

Thus, hyperinsulinemia can be linked back to the section "(A).

hyperinsulinemia Binding (linked) of associated with hyperinsulinism

6) Confidence 0.02 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.76 Pain Relevance 0.04

Significant insulin resistance and hyperinsulinemia has been observed to be associated with coronary heart disease in epidemiological studies, particularly so in Asian Indians.

hyperinsulinemia Binding (associated) of in heart associated with coronary artery disease, hyperinsulinism and insulin resistance

7) Confidence 0.01 Published 2000 Journal Indian Heart J Section Abstract Doc Link 10976147 Disease Relevance 1.08 Pain Relevance 0.06

Many cross-sectional epidemiologic studies also demonstrated positive association between intake of saturated fat and hyperinsulinemia, after adjustment for measure of body fat [56, 57], but at least one large, well-designed study showed no association [58].

hyperinsulinemia Binding (association) of in fat associated with hyperinsulinism

8) Confidence 0.01 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.41 Pain Relevance 0

Impaired fetal growth by 30% caloric restriction throughout gestation has also been described to be associated with hyperinsulinemia and hyperleptinemia in adult male offspring [9].

hyperinsulinemia Binding (associated) of associated with hyperinsulinism

9) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.77 Pain Relevance 0

Although increased plasma insulin levels should be associated with reduction in appetite [18], the hyperinsulinemia seen in CR animals, associated with hyperphagia, is likely to reflect reduced central insulin action.

hyperinsulinemia Binding (associated) of in plasma associated with hyperphagia and hyperinsulinism

10) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2939651 Disease Relevance 0.57 Pain Relevance 0

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