INT70641

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Context Info
Confidence 0.21
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.09

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peptidase activity (Pcsk5) extracellular space (Pcsk5) extracellular region (Pcsk5)
Golgi apparatus (Pcsk5)
Anatomy Link Frequency
LoVo 1
Pcsk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 2 99.20 Very High Very High Very High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pox Virus Infection 2 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In GH4C1 cells, PC1, PC2, furin, PC5-B, and PACE4 produced both N-terminal and C-terminal forms.
Gene_expression (produced) of PC5-B
1) Confidence 0.21 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9242664 Disease Relevance 0.08 Pain Relevance 0.04
To further define the role of each convertase, and particularly PC1 and PC2, in pro-TRH processing, recombinant vaccinia viruses were used to coexpress the prohormone convertases PC1, PC2, PACE4, PC5-B, furin, or control dynorphin together with rat prepro-TRH in constitutively secreting LoVo cells or in the regulated endocrine GH4C1 cell line.
Gene_expression (coexpress) of PC5-B in LoVo associated with pox virus infection and dynorphin
2) Confidence 0.19 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9242664 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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