INT70647

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.53
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CETP) transport (CETP) extracellular space (CETP)
small molecule metabolic process (CETP) extracellular region (CETP) lipid metabolic process (CETP)
Anatomy Link Frequency
plasmas 1
CETP (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 5 88.32 High High
ketamine 1 87.88 High High
Angina 8 46.96 Quite Low
Inflammation 24 41.52 Quite Low
agonist 15 32.32 Quite Low
alcohol 12 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 20 99.60 Very High Very High Very High
Hyperlipoproteinemia Type Ii 22 98.80 Very High Very High Very High
Disorder Of Lipid Metabolism 465 96.72 Very High Very High Very High
Cirrhosis 17 96.64 Very High Very High Very High
Liver Disease 14 92.00 High High
Disease 10 90.76 High High
Atherosclerosis 55 90.44 High High
Targeted Disruption 31 80.00 Quite High
Acute Coronary Syndrome 3 75.44 Quite High
Protein Deficiency 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We described the effect of the cholesteryl ester transfer protein (CETP) gene on CHD in heterozygous FH caused by low density lipoprotein receptor (LDL-R) gene mutation.
Regulation (effect) of CETP associated with coronary artery disease and hyperlipoproteinemia type ii
1) Confidence 0.61 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9242969 Disease Relevance 1.20 Pain Relevance 0
We described the effect of the cholesteryl ester transfer protein (CETP) gene on CHD in heterozygous FH caused by low density lipoprotein receptor (LDL-R) gene mutation.
Regulation (effect) of cholesteryl ester transfer protein associated with coronary artery disease and hyperlipoproteinemia type ii
2) Confidence 0.61 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9242969 Disease Relevance 1.19 Pain Relevance 0
Control and treated plasmas (post-heparin, post-heparin + lipases inhibitor and control + CETP monoclonal antibody, TP2, provided by Dr.
Regulation (control) of CETP in plasmas
3) Confidence 0.40 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31329 Disease Relevance 0.14 Pain Relevance 0.21
Apo AI infusions also modulate phospholipids transfer protein (PLTP), LCAT, and CETP activity, all of which potentially contribute to RCT (Kujiraoka et al 2003).
Regulation (modulate) of CETP
4) Confidence 0.19 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.65 Pain Relevance 0
Ox-LDL, CETP and PAI-1 were measured by means of sandwich ELISA; hs-CRP by means of nephelometry; and homocysteine by means of HPLC.
Regulation (measured) of CETP
5) Confidence 0.17 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.27 Pain Relevance 0
These changes are probably secondary to alterations in CETP, PLTP, and LCAT levels in these patients.
Spec (probably) Regulation (alterations) of CETP
6) Confidence 0.16 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.82 Pain Relevance 0
There was a dose response in CETP activity with JTT-130, and in addition, guinea pigs treated with atorvastatin exhibited decreased activity of this transfer protein.
Regulation (response) of CETP
7) Confidence 0.11 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.26 Pain Relevance 0

General Comments

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