INT70652

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.23
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
Gill 2
epithelial cell 2
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 10 96.68 Very High Very High Very High
Kinase C 15 95.48 Very High Very High Very High
peptic ulcer disease 2 93.48 High High
Prostatitis 1 53.36 Quite High
pain pelvic 1 43.28 Quite Low
imagery 1 25.52 Quite Low
cINOD 28 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 16 99.58 Very High Very High Very High
Interstitial Cystitis 10 96.68 Very High Very High Very High
Head & Neck Cancer 1 96.52 Very High Very High Very High
Infection 13 96.28 Very High Very High Very High
Apoptosis 45 95.44 Very High Very High Very High
Gastritis 2 94.04 High High
Cystitis 2 93.68 High High
Disease 56 92.96 High High
Pancreatic Cancer 70 91.68 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
H. pylori culture supernatant significantly reduced specific binding of EGF to its receptor and reduced EGF-stimulated gastric cell proliferation.
Negative_regulation (reduced) of EGF Binding (binding) of
1) Confidence 0.43 Published 1997 Journal Digestion Section Abstract Doc Link 9243127 Disease Relevance 0.83 Pain Relevance 0.07
Helicobacter pylori culture supernatant inhibits binding and proliferative response of human gastric cells to epidermal growth factor: implications for H.pylori interference with ulcer healing?
Negative_regulation (inhibits) of epidermal growth factor Binding (binding) of associated with ulcers
2) Confidence 0.43 Published 1997 Journal Digestion Section Title Doc Link 9243127 Disease Relevance 0.98 Pain Relevance 0.09
We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis.
Negative_regulation (decreased) of epidermal growth factor Binding (binding) of in epithelial cell associated with cystitis and interstitial cystitis
3) Confidence 0.39 Published 2001 Journal Urology Section Abstract Doc Link 11378043 Disease Relevance 0.91 Pain Relevance 0.45
Monoclonal antibodies interact with the extracellular domain of EGFR, inhibiting EGF ligand binding and inducing receptor endocytosis.
Negative_regulation (inhibiting) of EGF Binding (binding) of
4) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.65 Pain Relevance 0
M sulindac sulfone markedly decreased the ability of EGF to induce phosphorylation of EGFR; total EGFR expression levels and ERK1/2 phosphorylation were also downregulated (Figure 4), albeit to a lesser extent than with sulindac sulfide.
Negative_regulation (decreased) of EGF Binding (ability) of
5) Confidence 0.18 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.21 Pain Relevance 0
Cetuximab competitively blocks the binding of the EGF and other ligands to the EGFR thus preventing the activation of the downstream TK resulting in growth arrest and apoptosis (Gill et al 1984; Sato et al 1983; Baselga 2000).
Negative_regulation (blocks) of EGF Binding (binding) of in Gill associated with apoptosis
6) Confidence 0.15 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.50 Pain Relevance 0
For example, PS-ODNs can induce autophosphorylation of EGFR and thus, prevent the binding of EGF to its receptor [52].
Negative_regulation (prevent) of EGF Binding (binding) of
7) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.17 Pain Relevance 0.10

General Comments

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