INT70654

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 27
Total Number 31
Disease Relevance 18.62
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Actg2) cytoplasm (Actg2)
Anatomy Link Frequency
smooth muscle 22
PSCs 2
blood 1
granulocyte 1
neuron 1
Actg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 50 100.00 Very High Very High Very High
cytokine 17 99.84 Very High Very High Very High
chemokine 2 99.66 Very High Very High Very High
Inflammation 11 99.14 Very High Very High Very High
Chronic pancreatitis 35 93.84 High High
anesthesia 13 91.28 High High
Pain 6 87.88 High High
abdominal pain 3 84.72 Quite High
imagery 1 71.40 Quite High
Kinase C 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 55 100.00 Very High Very High Very High
Stress 7 99.90 Very High Very High Very High
Cancer 34 99.86 Very High Very High Very High
Necrosis 5 99.28 Very High Very High Very High
Obesity 1 99.28 Very High Very High Very High
INFLAMMATION 11 99.14 Very High Very High Very High
Primary Sclerosing Cholangitis 28 98.90 Very High Very High Very High
Apoptosis 13 98.08 Very High Very High Very High
Leiomyosarcoma 3 98.08 Very High Very High Very High
Injury 18 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry demonstrated that the tumor cells were positive for alpha-smooth muscle actin.
Gene_expression (positive) of alpha-smooth muscle actin in smooth muscle associated with cancer
1) Confidence 0.67 Published 2009 Journal J. Dermatol. Section Abstract Doc Link 19878394 Disease Relevance 0.84 Pain Relevance 0.09
Neoplastic cells were strongly positive for alpha-smooth muscle actin.
Gene_expression (positive) of alpha-smooth muscle actin in smooth muscle
2) Confidence 0.67 Published 1998 Journal Virchows Arch. Section Abstract Doc Link 9692833 Disease Relevance 0.73 Pain Relevance 0.10
Immunohistochemistry showed that the characteristic clusters in chylous fluids were positive for alpha-smooth muscle actin.
Gene_expression (positive) of alpha-smooth muscle actin in smooth muscle
3) Confidence 0.67 Published 2000 Journal Acta Cytol. Section Body Doc Link 11127739 Disease Relevance 0.07 Pain Relevance 0
Fibrinogen increased alpha-smooth muscle actin expression and induced the activation of nuclear factor-kappaB (NF-kappaB), Akt and three classes of mitogen-activated protein kinases (extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase and p38 mitogen-activated protein kinase (MAPK)).
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
4) Confidence 0.58 Published 2009 Journal Gut Section Body Doc Link 19052021 Disease Relevance 0 Pain Relevance 0
Chronic ethanol intake did not elicit any change in the expression of alpha-smooth muscle actin, cyclooxygenase 2, toll-like receptor 4, nuclear factor kappaB, pancreatic collagen, and superoxide dismutase.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
5) Confidence 0.57 Published 2008 Journal Pancreas Section Body Doc Link 18665082 Disease Relevance 0.07 Pain Relevance 0
PSC were isolated from rat pancreas and characterized for expression of glial fibrillary acidic protein, alpha-smooth muscle actin, CD95, and tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) receptors.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle associated with necrosis, cancer, primary sclerosing cholangitis and apoptosis
6) Confidence 0.52 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12181199 Disease Relevance 1.32 Pain Relevance 0.09
Pancreatic blood flow was detected by intravital microscope; malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were measured in pancreatic tissues for assessment of oxidative stress and alpha-smooth muscle actin (alpha-SMA) expression was determined by immunohistochemical staining and RT-PCR.
Gene_expression (expression) of alpha-smooth muscle actin in blood associated with stress
7) Confidence 0.47 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16814251 Disease Relevance 0.81 Pain Relevance 0.08
These spindle-shaped cells were also positive for alpha-smooth muscle actin, the marker of myofibroblasts.
Gene_expression (positive) of alpha-smooth muscle actin in smooth muscle
8) Confidence 0.47 Published 2004 Journal J. Mol. Histol. Section Body Doc Link 15609091 Disease Relevance 0 Pain Relevance 0
Pressure increased the expression levels of alpha-smooth muscle actin, alpha(1)(I)-procollagen, and TGF-beta1 in PSCs.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
9) Confidence 0.47 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.36 Pain Relevance 0.22
Furthermore, lovastatin inhibited induction of alpha-smooth muscle actin expression in the course of primary culture.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
10) Confidence 0.47 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12694870 Disease Relevance 0.39 Pain Relevance 0.09
Expression of alpha-smooth muscle actin (an indicator of the myofibroblastic phenotype), ERK activation and membrane translocation of the Ras superfamily member RhoA were analysed by immunoblotting.
Spec (analysed) Gene_expression (Expression) of alpha-smooth muscle actin in smooth muscle
11) Confidence 0.47 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12694870 Disease Relevance 0.62 Pain Relevance 0.14
DPI inhibited PDGF-induced proliferation, IL-1beta-induced chemokine production, and expression of alpha-smooth muscle actin and collagen.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle associated with chemokine
12) Confidence 0.37 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962358 Disease Relevance 0.49 Pain Relevance 0.35
Pressure increased the expression levels of alpha-smooth muscle actin, alpha(1)(I)-procollagen, and TGF-beta1 in PSCs.
Gene_expression (levels) of alpha-smooth muscle actin in smooth muscle
13) Confidence 0.36 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.36 Pain Relevance 0.22
Pancreatic stellate cell proliferation, alpha-smooth muscle actin (alpha-SMA) expression, and collagen production were determined by colorimetric conversion assay, Western blot analysis, and Sirius red dye binding assay, respectively.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
14) Confidence 0.34 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.18 Pain Relevance 0
MAPK protein levels and alpha-smooth muscle actin (alpha-SMA) expression were evaluated by Western blot analysis.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
15) Confidence 0.33 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.16 Pain Relevance 0.12
Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta1 (TGF-beta1), fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and type III collagen was analyzed.
Spec (analyzed) Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle associated with fibrosis
16) Confidence 0.32 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.87 Pain Relevance 0.59
INTERVENTION(S): Immunohistochemical staining of endometriotic specimens for alpha-smooth muscle actin (ASMA), neural cell adhesion molecule (NCAM), and nerve growth factor (NGF) expression.
Gene_expression (expression) of alpha-smooth muscle actin in neural
17) Confidence 0.25 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18930216 Disease Relevance 0.14 Pain Relevance 0
The tumor cells expressed HMB45 and alpha-smooth muscle actin.
Gene_expression (expressed) of alpha-smooth muscle actin in smooth muscle associated with cancer
18) Confidence 0.25 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19712133 Disease Relevance 1.06 Pain Relevance 0.08
Parameters of inflammation and fibrosis, positive immunostaining for alpha-smooth muscle actin, and gene expression of cytokine and growth factors were assessed, as well as circulating renin-angiotensin system components.
Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle associated with fibrosis, inflammation and cytokine
19) Confidence 0.23 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15608084 Disease Relevance 0.62 Pain Relevance 0.34
To examine calponin expression and structural changes of periglomerular calponin-positive glomeruli, five serial tissue sections were stained with periodic acid-methenamine silver (PAMS), alpha-smooth muscle actin (ASMA) antiserum, calponin antiserum, vimentin antiserum, and the periodic acid-Schiff (PAS) method.
Spec (examine) Gene_expression (expression) of alpha-smooth muscle actin in smooth muscle
20) Confidence 0.21 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0 Pain Relevance 0

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