INT70667

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (JUND)
Anatomy Link Frequency
SH-SY5Y 1
immune cells 1
JUND (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
Inflammation 5 100.00 Very High Very High Very High
Morphine 4 98.00 Very High Very High Very High
psoriasis 1 95.72 Very High Very High Very High
rheumatoid arthritis 2 95.28 Very High Very High Very High
Multiple sclerosis 2 94.40 High High
Pain 4 90.80 High High
antagonist 1 75.76 Quite High
Osteoarthritis 15 75.20 Quite High
narcan 1 74.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Autoimmune Disease 6 99.92 Very High Very High Very High
Inflammatory Bowel Disease 2 97.00 Very High Very High Very High
Psoriasis 1 95.72 Very High Very High Very High
Lung Cancer 1 95.52 Very High Very High Very High
Rheumatoid Arthritis 2 95.28 Very High Very High Very High
Demyelinating Disease 2 94.40 High High
Neuroblastoma 1 94.00 High High
Injury 1 91.20 High High
Pain 4 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, c-jun and junD activity were affected by glucosamine pretreatment in HPCs.
Regulation (affected) of junD
1) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0.30 Pain Relevance 0.15
These treatments did not alter activities of AP-1, NF-kappa B and YY1 transcription factors in SH-SY5Y cells or NF-kappa B and YY1 in U1690 cells.
Neg (not) Regulation (alter) of AP-1 in SH-SY5Y
2) Confidence 0.18 Published 1997 Journal Neuroreport Section Abstract Doc Link 9243600 Disease Relevance 0.19 Pain Relevance 0.42
Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.
Regulation (regulating) of AP-1 in immune cells associated with autoimmune disease, inflammation and cytokine
3) Confidence 0.02 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569223 Disease Relevance 1.88 Pain Relevance 0.48

General Comments

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