INT70668

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.58
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1F) signal transducer activity (HTR1F)
HTR1F (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 7 99.16 Very High Very High Very High
Potency 2 98.92 Very High Very High Very High
Migraine 3 96.84 Very High Very High Very High
Serotonin 3 96.16 Very High Very High Very High
Inflammation 6 92.00 High High
Trigeminal ganglion neurons 1 87.28 High High
trigeminal ganglion 1 65.92 Quite High
Disease Link Frequency Relevance Heat
Headache 3 96.84 Very High Very High Very High
Neurogenic Inflammation 1 92.00 High High
Ganglion Cysts 2 86.40 High High
INFLAMMATION 3 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potency of agonists in inhibiting adenylate cyclase in cells transfected with human 5-HT1F receptor was also highly correlated with their potency in the animal model of migraine.
Positive_regulation (transfected) of Gene_expression (transfected) of 5-HT1F associated with migraine, agonist and potency
1) Confidence 0.49 Published 1997 Journal Neuroreport Section Abstract Doc Link 9243618 Disease Relevance 0.43 Pain Relevance 0.70
When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself.
Positive_regulation (transfected) of Gene_expression (transfected) of 5-HT1F associated with agonist and serotonin
2) Confidence 0.49 Published 1997 Journal Life Sci. Section Abstract Doc Link 9395253 Disease Relevance 0.15 Pain Relevance 0.32

General Comments

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