INT7067

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.08
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
liver 2
Sertoli cells 2
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 94.44 High High
Opioid 2 92.40 High High
rheumatoid arthritis 30 87.20 High High
antagonist 1 64.00 Quite High
cytokine 1 14.88 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 2 94.44 High High
Hypertension 43 93.92 High High
Hyperinsulinism 6 93.68 High High
Disorder Of Lipid Metabolism 49 93.08 High High
Insulin Resistance 12 92.56 High High
Polycystic Ovary Syndrome 52 92.04 High High
Coronary Heart Disease 3 91.96 High High
Coronary Artery Disease 6 91.00 High High
Rheumatoid Arthritis 30 87.20 High High
Hyperandrogenism 7 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduced double product (SBP X HR) with submaximal exertion results in a decrease in cardiac work and correlates with enhanced exercise capacity and delay in onset of angina during exercise testing.
Negative_regulation (reduced) of Gene_expression (product) of SBP associated with angina
1) Confidence 0.41 Published 1986 Journal Am. J. Cardiol. Section Abstract Doc Link 3513517 Disease Relevance 1.04 Pain Relevance 0.09
Production of SHBG is inhibited by insulin; therefore, low levels of SHBG are associated with elevated insulin levels.
Negative_regulation (inhibited) of Gene_expression (Production) of SHBG
2) Confidence 0.32 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.41 Pain Relevance 0
At the same time insulin decreases the production of SHBG in the liver, leading to increased levels of free active testosterone.
Negative_regulation (decreases) of Gene_expression (production) of SHBG in liver
3) Confidence 0.28 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.27 Pain Relevance 0.03
For example, it is thought that some specific functions of Sertoli cells, such as androgen-binding protein production are decreased by a paracrine mechanism.
Negative_regulation (decreased) of Gene_expression (production) of androgen-binding protein in Sertoli cells
4) Confidence 0.23 Published 1992 Journal Hum. Reprod. Section Abstract Doc Link 1337904 Disease Relevance 0.16 Pain Relevance 0.16
However, with the valsartan/amlodipine combination, the further mean reduction in BP (SBP/DBP: ?
Negative_regulation (reduction) of Gene_expression (/) of SBP
5) Confidence 0.22 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
After supplementation, SBP levels decreased significantly in the group C in comparison with groups E and P and mean arterial pressure reduced significantly in groups C and CE.
Negative_regulation (decreased) of Gene_expression (levels) of SBP
6) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2663461 Disease Relevance 0.61 Pain Relevance 0.16
After three months of supplementation in the group C, SBP levels reduced significantly by 8% (117.36 ± 3.80 mmHg versus 108.04 ± 3.13 mmHg) (P < 0.05) and DBP by 8.5% (72.36 ± 2.37 mmHg versus 66.14 ± 1.66 mmHg) (P < 0.05).
Negative_regulation (reduced) of Gene_expression (levels) of SBP
7) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663461 Disease Relevance 0.59 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox