INT70673

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.89
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL11) extracellular region (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
decidua 2
hematopoietic stem cells 1
uterine 1
urine 1
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 55 99.68 Very High Very High Very High
rheumatoid arthritis 22 97.92 Very High Very High Very High
metalloproteinase 8 95.16 Very High Very High Very High
chemokine 3 91.76 High High
Inflammation 13 89.60 High High
Arthritis 2 88.08 High High
palliative 2 82.40 Quite High
Pain 8 78.20 Quite High
Inflammatory response 7 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucositis 8 98.76 Very High Very High Very High
Hypercalcemia 11 98.24 Very High Very High Very High
Rheumatoid Arthritis 22 97.92 Very High Very High Very High
Bone Cancer 6 97.00 Very High Very High Very High
Adhesions 14 93.82 High High
Leukemia 4 92.72 High High
INFLAMMATION 21 89.60 High High
Arthritis 2 88.08 High High
Synovitis 2 84.64 Quite High
Cancer 7 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis

Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production.

Regulation (controlled) of interleukin-11 in hematopoietic stem cells associated with rheumatoid arthritis and cytokine
1) Confidence 0.45 Published 2001 Journal Arthritis Res Section Title Doc Link PMC34114 Disease Relevance 0.70 Pain Relevance 0.34
The present study was undertaken to evaluate the effect of rhIL-11 on two consecutive courses of mucositis and myelosuppression in hamsters.
Regulation (effect) of rhIL-11 associated with mucositis
2) Confidence 0.39 Published 1997 Journal Cytokine Section Abstract Doc Link 9245489 Disease Relevance 0.82 Pain Relevance 0.16
This is likely to be a compensatory mechanism accounting for the large increase in IL-11, as seen in first trimester decidua and acts to control IL-11's signalling potential and to maintain specificity between other GP130 signalling cytokines.
Regulation (control) of IL-11 in decidua associated with cytokine
3) Confidence 0.36 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
However, the molecular mechanism regulating IL-11 and its autocrine/paracrine role in human uterine function of early pregnancy is unclear.
Regulation (regulating) of IL-11 in uterine
4) Confidence 0.36 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.05 Pain Relevance 0.09
We further confirmed PROK1 regulation of IL-11 in first trimester decidua using miRNA constructs targeted to PROK1.
Regulation (regulation) of IL-11 in decidua
5) Confidence 0.36 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.04
, RANTES, histamine: Beckman-Coulter, Krefeld, Germany; IL-4, IL-10, IL-13, soluble intracellular adhesion molecule-1 (sICAM-1), platelet endothelial cell adhesion molecule-1 (PECAM): Bender MedSystems, Vienna, Austria; IL-5, IL-6 high sensitivity, IL-10 high sensitivity, IL-12 p40/p70, soluble leukocytic (sL)-selectin, sE-selectin: R&D Systems GmbH, Wiesbaden, Germany; IL-2, IL-2-receptor, serum and urine neopterin: DPC Biermann GmbH, Bad Nauheim, Germany; IL-4 high sensitivity, IL-11: Natutec, Frankfurt, Germany; IL-12 p70, IL-13: Biozol Diagnostica Ver-trieb GmbH, Eching, Germany; C5a: Behringwerke AG, Marburg, Germany].
Regulation (sensitivity) of IL-11 in urine associated with adhesions
6) Confidence 0.26 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.24 Pain Relevance 0
In the present study, we investigated the role of PROK1–PROKR1 modulation of IL-11.
Spec (investigated) Regulation (modulation) of IL-11
7) Confidence 0.21 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.14 Pain Relevance 0.10
Similarly, other cytokines, such as IL-1, IL-11 and TNF influence ostoclast function and the age associated dysregulation of these cytokines may also contribute to the development of osteoporotic bone disease [8].
Regulation (dysregulation) of IL-11 associated with bone cancer and cytokine
8) Confidence 0.01 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1242225 Disease Relevance 0.94 Pain Relevance 0.43

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