INT70701

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.20
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCGR3A) plasma membrane (FCGR3A)
FCGR3A (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 2 100.00 Very High Very High Very High
tramadol 2 98.76 Very High Very High Very High
Pain 2 81.76 Quite High
abatacept 3 50.00 Quite Low
antagonist 15 41.12 Quite Low
Calcium channel 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 98 100.00 Very High Very High Very High
Disease 17 96.50 Very High Very High Very High
Fever 1 82.32 Quite High
Pain 2 81.76 Quite High
Exanthema 2 77.76 Quite High
Thyroiditis 1 74.32 Quite High
Death 3 67.24 Quite High
Mental Disorders 2 41.28 Quite Low
Cv General 4 Under Development 10 5.00 Very Low Very Low Very Low
Dyspnea 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A group of 15 patients with refractory Hodgkin's disease were treated in a phase I/II trial with the natural-killer (NK)-cell-activating bispecific monoclonal antibody HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's associated CD30 antigen.
CD16 Binding (associated) of associated with disease
1) Confidence 0.36 Published 1997 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 9435869 Disease Relevance 0.41 Pain Relevance 0.08
Protein L (IgG kappa-chain-binding bacterial protein) showed a precipitate line(pseudo-immuno-reaction) with IgG and F(ab')2 fragment, but did not show any line with the Fab fragment, the Fc fragment and free kappa-chains in the micro-Ouchterlony method.
IgG Binding (binding) of
2) Confidence 0.16 Published 1997 Journal Immunol. Invest. Section Abstract Doc Link 9246561 Disease Relevance 0.15 Pain Relevance 0.08
Bosentan has been shown to be effective at improving exercise tolerance in PAH patients in FC III and IV in randomized controlled trials.
FC III Binding (tolerance) of associated with pulmonary hypertension and tolerance
3) Confidence 0.12 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.64 Pain Relevance 0.05
While abatacept was found to bind its target receptor, CD80/86, it did not appreciably bind the low-affinity Fc receptors CD16 and CD32 as measured by flow cytometry and SPR.
Fc receptors CD16 Neg (not) Binding (bind) of
4) Confidence 0.03 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17787038 Disease Relevance 0 Pain Relevance 0
With tramadol and its phase I metabolites selected as model compounds, the HS-gamma-CD was found to be the most appropriate chiral selector.
HS-gamma-CD Binding (found) of associated with tramadol
5) Confidence 0.02 Published 2004 Journal Electrophoresis Section Abstract Doc Link 15352008 Disease Relevance 0 Pain Relevance 0.17

General Comments

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