INT70725

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.40
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
nerve 2
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 100.00 Very High Very High Very High
Potency 6 99.42 Very High Very High Very High
local anesthetic 18 97.68 Very High Very High Very High
nerve block 2 96.56 Very High Very High Very High
lidocaine 4 95.20 Very High Very High Very High
agonist 5 89.52 High High
depression 2 88.08 High High
Opioid 1 83.48 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.72 Very High Very High Very High
Cardiovascular Disorder Under Development 2 89.28 High High
Overdose 2 84.88 Quite High
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of clear stereospecificity is consistent with the relatively low potency these agents demonstrate at inhibition of beta2AR binding.
Negative_regulation (inhibition) of beta2AR Binding (binding) of associated with potency
1) Confidence 0.57 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.17 Pain Relevance 0.86
The correlation between increased inhibition of beta2AR binding and alkyl chain length resembles the correlation between local anesthetic potency at nerve block and increased alkyl chain length.
Negative_regulation (inhibition) of beta2AR Binding (binding) of in nerve associated with nerve block, potency and local anesthetic
2) Confidence 0.42 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.13 Pain Relevance 0.87
In addition, SCH-202676 inhibited antagonist binding to the beta2-adrenergic receptor expressed in Escherichia coli, a system devoid of classical heterotrimeric G proteins.
Negative_regulation (inhibited) of beta2-adrenergic Binding (binding) of associated with antagonist
3) Confidence 0.00 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.10 Pain Relevance 0.41

General Comments

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