INT70726

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.20
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 99.10 Very High Very High Very High
local anesthetic 9 96.00 Very High Very High Very High
Potency 3 89.52 High High
nerve block 1 84.88 Quite High
lidocaine 2 75.04 Quite High
Disease Link Frequency Relevance Heat
Overdose 1 99.86 Very High Very High Very High
Cardiovascular Disorder Under Development 1 99.10 Very High Very High Very High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the relatively potent inhibition of beta2ARs by etidocaine, tetracaine, and bupivacaine suggests that their propensity for cardiovascular depression after accidental intravenous overdose could result from beta2AR or beta1AR blockade and inhibition of cAMP production.
Positive_regulation (result) of Negative_regulation (blockade) of beta2AR associated with depression, overdose and cardiovascular disorder under development
1) Confidence 0.49 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9249110 Disease Relevance 0.20 Pain Relevance 0.86

General Comments

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