INT70738

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.00
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg2) plasma membrane (Gabrg2) cytoplasm (Gabrg2)
Anatomy Link Frequency
neuronal 2
cortex 1
Gabrg2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 52 99.54 Very High Very High Very High
tetrodotoxin 1 99.48 Very High Very High Very High
Pain 25 97.68 Very High Very High Very High
Neuronal excitability 5 97.24 Very High Very High Very High
imagery 9 95.04 Very High Very High Very High
sSRI 4 95.04 Very High Very High Very High
fluoxetine 3 91.36 High High
Electroencephalography 1 89.88 High High
depression 10 76.28 Quite High
cerebral cortex 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Febrile Convulsions 60 100.00 Very High Very High Very High
Targeted Disruption 69 99.44 Very High Very High Very High
Pain 21 97.68 Very High Very High Very High
Convulsion 75 94.24 High High
Anxiety Disorder 8 90.92 High High
Syncope 2 79.72 Quite High
Post-traumatic Stress Disorder 2 79.24 Quite High
Depression 9 76.28 Quite High
Absence Epilepsy 2 75.64 Quite High
Stress 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have demonstrated that male mice that have been socially isolated for more than 4 weeks show: (a) reduced responsiveness of GABA(A) receptors (GABA(A)-R) to the administrations of GABA mimetic drugs at GABA(A)-R; (b) downregulated biosynthesis of 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP) (allopregnanolone: ALLO), a neurosteroid with a potent positive allosteric modulatory effect on the action of GABA on GABA(A)-R; and (c) alterations in the expression of GABA(A)-R subunits (i.e. a decrease of alpha1/alpha2 and gamma2 subunits and an increase of alpha4 and alpha5 subunits).
Negative_regulation (decrease) of gamma2 associated with gaba
1) Confidence 0.57 Published 2007 Journal Stress Section Abstract Doc Link 17454962 Disease Relevance 0.88 Pain Relevance 0.95
More robust changes in steroid hormone levels, such as those that occur throughout pregnancy, result in a decrease in both GABAAR gamma2 and delta subunit expression and are associated with an increase in neuronal excitability evident from the shift in the input-output relationship.
Negative_regulation (decrease) of gamma2 in neuronal associated with neuronal excitability
2) Confidence 0.41 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19632051 Disease Relevance 0.55 Pain Relevance 0.36
In both of these severely affected K4425 patients, we ruled out additional modifying mutations in four other known FS susceptibility genes, SCN1A, SCN2A, SCN1B and GABRG2, by sequencing the coding and splice site regions.


Negative_regulation (known) of GABRG2 associated with febrile convulsions
3) Confidence 0.37 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 1.32 Pain Relevance 0.04
This reduction was paralleled by significant decreases of evoked phase-ordered gamma2 and gamma3 patterns over Cz scalp site.
Negative_regulation (decreases) of gamma2
4) Confidence 0.31 Published 2005 Journal Int J Psychophysiol Section Abstract Doc Link 15804450 Disease Relevance 0.78 Pain Relevance 1.30
1 subunit of the GABAA-R was also reduced (Figure 4B).
Negative_regulation (reduced) of GABAA-R
5) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.28 Pain Relevance 0.04
The synaptic formation of gephyrin and GABAA receptor clusters are mutually dependent on each other: neuronal cultures from gephyrin knock out mice show an extensive loss of alpha2 and gamma2 containing GABAA receptor clusters and vice versa in GABAA receptor gamma2 subunit knock out mice the synaptic gephyrin clusters are absent and the remaining alpha-beta containing receptors are diffusely distributed on the cell surface (Craig et al., 1996; Essrich et al., 1998; G√ľnther et al., 1995).
Negative_regulation (loss) of gamma2 in neuronal associated with targeted disruption
6) Confidence 0.20 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.20 Pain Relevance 0.09
Monocular deprivation for 1-3 weeks, induced by intravitreal injection of tetrodotoxin, resulted in substantial reductions in levels of alpha 1, beta 2, and gamma 2 subunit mRNAs in deprived ocular dominance columns of the visual cortex, but the other subunit mRNAs were largely unaffected by monocular deprivation.
Negative_regulation (reductions) of gamma 2 in cortex associated with tetrodotoxin
7) Confidence 0.00 Published 1997 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9250379 Disease Relevance 0 Pain Relevance 0.20

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