INT70739

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.15
Pain Relevance 4.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg2) plasma membrane (Gabrg2) cytoplasm (Gabrg2)
Anatomy Link Frequency
neurons 3
dorsal 2
neuronal 1
cortex 1
body 1
Gabrg2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 116 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
Hippocampus 60 99.18 Very High Very High Very High
Neuronal excitability 6 98.40 Very High Very High Very High
Thalamus 7 97.04 Very High Very High Very High
GABAergic 67 95.96 Very High Very High Very High
sSRI 4 95.04 Very High Very High Very High
Glutamate 29 94.80 High High
cINOD 4 93.24 High High
Inflammation 2 92.76 High High
Disease Link Frequency Relevance Heat
Brain Injury 62 99.36 Very High Very High Very High
Body Weight 38 95.36 Very High Very High Very High
Injury 66 93.52 High High
INFLAMMATION 2 92.76 High High
Post-traumatic Stress Disorder 2 90.04 High High
Anxiety Disorder 15 89.96 High High
Convulsion 11 88.48 High High
Depression 18 87.08 High High
Targeted Disruption 137 86.40 High High
Cognitive Disorder 8 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alteration to GABAAR expression may be due to phosphorylation of subunit proteins.
Gene_expression (expression) of GABAAR
1) Confidence 0.75 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2893123 Disease Relevance 0.86 Pain Relevance 0.16
More robust changes in steroid hormone levels, such as those that occur throughout pregnancy, result in a decrease in both GABAAR gamma2 and delta subunit expression and are associated with an increase in neuronal excitability evident from the shift in the input-output relationship.
Gene_expression (expression) of gamma2 in neuronal associated with neuronal excitability
2) Confidence 0.75 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19632051 Disease Relevance 0.54 Pain Relevance 0.36
Inhibitory neurons of the dorsal hippocampus that express nAChRs also constitutively express COX-2 and the peroxisome proliferator-antagonist receptor subtype gamma-2 (PPAR gamma2) which is also a target of NS398.
Gene_expression (express) of gamma2 in dorsal associated with antagonist and hippocampus
3) Confidence 0.75 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.33 Pain Relevance 0.58
Following the harvesting of the cytoplasmic contents of individual GnRH neurons, single cell multiplex RT-PCR experiments demonstrated that GABAA receptor alpha1-5, beta1-3 and gamma2 & 3 subunit transcripts were expressed by both neonatal (postnatal day 5) and juvenile (day 15-20) GnRH neurons in a heterogeneous manner.
Gene_expression (expressed) of gamma2 in neurons
4) Confidence 0.65 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.20
Among the various GABAA-R subunits, the alpha1, alpha4, beta2, and delta subunits are heavily expressed in thalamic relay nuclei.
Gene_expression (expressed) of GABAA-R
5) Confidence 0.33 Published 2007 Journal Alcohol Section Abstract Doc Link 17521848 Disease Relevance 0.20 Pain Relevance 0.70
Blots of cortex from forebrain selective knockouts and controls were also analyzed for GABAA-R ?
Spec (analyzed) Gene_expression (analyzed) of GABAA-R in cortex
6) Confidence 0.29 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.20 Pain Relevance 0.04
Recent studies have demonstrated that male mice that have been socially isolated for more than 4 weeks show: (a) reduced responsiveness of GABA(A) receptors (GABA(A)-R) to the administrations of GABA mimetic drugs at GABA(A)-R; (b) downregulated biosynthesis of 3alpha,5alpha-tetrahydroprogesterone (3alpha,5alpha-THP) (allopregnanolone: ALLO), a neurosteroid with a potent positive allosteric modulatory effect on the action of GABA on GABA(A)-R; and (c) alterations in the expression of GABA(A)-R subunits (i.e. a decrease of alpha1/alpha2 and gamma2 subunits and an increase of alpha4 and alpha5 subunits).
Gene_expression (biosynthesis) of gamma2 associated with gaba
7) Confidence 0.29 Published 2007 Journal Stress Section Abstract Doc Link 17454962 Disease Relevance 0.97 Pain Relevance 0.96
Overexpression of GABARAP in heterologous cells or cultured hippocampal neurons enhances the cell surface expression of gamma2 containing GABAA receptors.
Gene_expression (expression) of gamma2 in neurons
8) Confidence 0.27 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.08 Pain Relevance 0.03
The ability to manipulate expression of a predominant GABAA-R subunit in an anatomically-specific manner is an important first step in unraveling the role of GABA in regulating body weight.
Gene_expression (expression) of GABAA-R in body associated with gaba and body weight
9) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100059 Disease Relevance 0.48 Pain Relevance 0.44
Inhibitory neurons of the dorsal hippocampus that express nAChRs also constitutively express COX-2 and the peroxisome proliferator-antagonist receptor subtype gamma-2 (PPAR gamma2) which is also a target of NS398.
Gene_expression (express) of gamma-2 in dorsal associated with antagonist and hippocampus
10) Confidence 0.18 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.33 Pain Relevance 0.58
Alldred et al. (2005) showed, that in gamma2 deficient neurons only transfection with exogenous gamma2, but not alpha2 rescues synaptic clustering of GABAA receptors, the recruitment of gephyrin and normal amplitude and frequency of mIPSCs.
Gene_expression (transfection) of gamma2 in neurons
11) Confidence 0.18 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.16 Pain Relevance 0.03
Seven monkey-specific cDNAs corresponding to alpha 1, alpha 2, alpha 4, alpha 5, beta 1, beta 2, and gamma 2 GABAA receptor subunits were isolated and cloned; radioactive cDNA and cRNA probes were used for Northern blot analysis and in situ hybridization histochemistry of the primary visual, somatosensory, motor, temporal, and anterior parietal areas. alpha 1, beta 2, and gamma 2 subunit mRNAs were expressed at much higher levels than the other mRNAs, indicating that most cortical GABAA receptors are assembled from these three subunits. alpha 1, beta 2, and gamma 2 were also more highly expressed in area 17 than in all other areas, reflecting the greater density of GABA cells and synapses in area 17.
Gene_expression (expressed) of gamma 2 in parietal associated with gaba
12) Confidence 0.01 Published 1997 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9250379 Disease Relevance 0 Pain Relevance 0.09

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