INT70744

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 7.38
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
Anatomy Link Frequency
blood 2
heart 1
kidney 1
CFH (Homo sapiens)
CFH - Y402H (1)
Pain Link Frequency Relevance Heat
ganglionectomy 66 99.36 Very High Very High Very High
Pain 16 89.44 High High
midbrain 11 83.56 Quite High
medulla 95 83.04 Quite High
pain pelvic 1 65.36 Quite High
cva 14 56.56 Quite High
Inflammation 7 55.44 Quite High
ischemia 1 52.56 Quite High
methotrexate 1 25.00 Low Low
Angina 1 10.40 Low Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 125 100.00 Very High Very High Very High
Nicotine Addiction 16 99.90 Very High Very High Very High
Thrombosis Related Under Development 6 99.80 Very High Very High Very High
Hypertension 11 99.32 Very High Very High Very High
Syncope 69 99.24 Very High Very High Very High
Acute Renal Failure 8 98.98 Very High Very High Very High
Ectopic Pregnancy 10 98.76 Very High Very High Very High
Myocardial Infarction 11 98.56 Very High Very High Very High
Disease 56 98.48 Very High Very High Very High
Thrombocytopenia 2 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in beta-hCG levels in normal, failing and ectopic pregnancy are now reasonably well characterised, and at early stages of presentation where the risk of rupture of an ectopic are minimal, the patient can often be managed as an outpatient while the diagnosis is pursued.
Regulation (Changes) of beta-hCG associated with rupture and ectopic pregnancy
1) Confidence 0.41 Published 2009 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 18665380 Disease Relevance 1.01 Pain Relevance 0.23
Atypical HUS (aHUS) is characterised by the triad of a microangiopathic haemolytic anaemia (Coombs' test negative), thrombocytopenia, and acute renal failure in the absence of a preceding diarrhoeal illness. aHUS can be either sporadic or, if more than one member of a family is affected, familial.
Regulation (affected) of aHUS associated with acute renal failure, hemolytic anemia, thrombocytopenia and hemolytic uremic syndrome
2) Confidence 0.39 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.49 Pain Relevance 0
In 2006, Kardys and colleagues investigated the role of the Y402H polymorphism in the CFH gene and reported an increased risk for myocardial infarction in those who were homozygous for the His variant [10].
Spec (investigated) Regulation (role) of CFH gene (Y402H) associated with myocardial infarction
3) Confidence 0.27 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048938 Disease Relevance 0.61 Pain Relevance 0.03
In people with mutations affecting proteins produced by the kidney, a kidney transplant would be likely to work; but in people with mutations affecting factor H, which is produced by the liver, the disease would probably recur after a kidney transplant.


Regulation (affecting) of factor H in kidney associated with disease
4) Confidence 0.27 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1626556 Disease Relevance 0.34 Pain Relevance 0
METHODS: This was a retrospective chart review of all patients who presented to the ED of an urban teaching hospital from August 1991 through July 1995 with lower abdominal pain or bleeding, a positive beta-hCG assay, and a quantitative beta-hCG value lower than 1,000 mIU/mL in whom pelvic transvaginal ultrasound was performed within 24 hours of the ED visit.
Regulation (value) of beta-hCG
5) Confidence 0.22 Published 1997 Journal Ann Emerg Med Section Body Doc Link 9250634 Disease Relevance 0.17 Pain Relevance 0
Five of the nine had beta-hCG values lower than 500 mIU/mL.
Regulation (values) of beta-hCG
6) Confidence 0.22 Published 1997 Journal Ann Emerg Med Section Body Doc Link 9250634 Disease Relevance 0 Pain Relevance 0
The beta-hCG values for the patients with diagnostic examinations ranged from 47 to 995 mIU/mL.
Spec (examinations) Regulation (values) of beta-hCG
7) Confidence 0.22 Published 1997 Journal Ann Emerg Med Section Body Doc Link 9250634 Disease Relevance 0.11 Pain Relevance 0
In this manner, area under the curve was derived for the LF region, 0.05 – 0.15 Hz (28 bins), and for the HF region, 28 bins encompassing the ventilatory related peak.
Regulation (derived) of HF
8) Confidence 0.09 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0 Pain Relevance 0
Factor H deficiency is responsible for thrombotic microangiopathy (TMA) via uncontrolled activation of the alternative pathway of the complement system.
Regulation (responsible) of Factor H associated with thrombosis related under development
9) Confidence 0.06 Published 2007 Journal Pediatr. Nephrol. Section Abstract Doc Link 17619907 Disease Relevance 0.90 Pain Relevance 0.12
A second objective was evaluate the extent to which right stellate ganglionectomy would alter LF activity and LF/HF values in HRV spectra.
Regulation (values) of HF associated with ganglionectomy
10) Confidence 0.06 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.52 Pain Relevance 0.09
Whereas ANOVARM demonstrated a significant global effect of epoch on the LF nu-RRI and HF nu-RRI, the GEE model showed only a non-significant trend for an increase of the mean LF nu-RRI and a mirror decrease of the mean HF nu-RRI (p = 0.056) over the monitoring period.
Regulation (effect) of HF nu-RRI
11) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0 Pain Relevance 0
These observations are noteworthy since we also demonstrate an association between high frequency or “vagal” regulation of the heart (HF-HRV) and frequency of syncope in our NCS participants.
Regulation (regulation) of HF-HRV in heart associated with syncope
12) Confidence 0.01 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.80 Pain Relevance 0.19
Since the baseline SD values of the LF nu-RRI and HF nu-RRI were statistically different, separate GEE models were computed for each group; these separate GEE models showed no significant effect for the sham and anodal groups (p > 0.277) but showed a significant decrease (increase) of the SD values for the LF nu-RRI (HF nu-RRI) over time for the cathodal group only (p = 0.044).
Regulation (values) of HF nu-RRI
13) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0 Pain Relevance 0
Only 21%, 48%, 37%, 48%, and 36%, respectively, correctly identified how diet, special vitamins, high blood pressure, family history, and smoking can affect ARMD.
Regulation (affect) of ARMD in blood associated with nicotine addiction, hypertension and age-related macular degeneration
14) Confidence 0.00 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2866567 Disease Relevance 1.14 Pain Relevance 0.09
Although 77% felt they were moderately or very knowledgeable about ARMD, only 21%, 48%, 37%, 48%, and 36%, of patients respectively, correctly identified how diet, special vitamins, high blood pressure, family history, and smoking can affect ARMD (Figure 2).
Regulation (affect) of ARMD in blood associated with nicotine addiction, hypertension and age-related macular degeneration
15) Confidence 0.00 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2866567 Disease Relevance 1.30 Pain Relevance 0.05

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