INT70757

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Context Info
Confidence 0.03
First Reported 1997
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.23
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) extracellular region (Pnoc) plasma membrane (Oprl1)
signal transducer activity (Oprl1)
Anatomy Link Frequency
neural 1
Oprl1 (Mus musculus)
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 20 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
Dynorphin 3 99.84 Very High Very High Very High
Kappa opioid receptor 4 97.48 Very High Very High Very High
opioid receptor 5 92.08 High High
Enkephalin 2 89.76 High High
Potency 1 72.40 Quite High
Immobilon 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Erectile Dysfunction 2 87.88 High High
Nociception 1 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIM: To study the mechanism of interaction of nociceptin and opioids with ORL1 receptor.
ORL1 receptor Binding (interaction) of nociceptin associated with orphanin and opioid
1) Confidence 0.03 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11360688 Disease Relevance 0 Pain Relevance 0.30
Nociceptin, a novel endogenous ligand for the ORL1 receptor, has potent erectile activity in the cat.
ORL1 receptor Binding (ligand) of Nociceptin associated with orphanin
2) Confidence 0.01 Published 1997 Journal Am. J. Physiol. Section Title Doc Link 9252499 Disease Relevance 0.23 Pain Relevance 0.42
Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural mu 3 opiate receptor.
mu 3 opiate receptor Neg (not) Binding (interact) of Nociceptin in neural associated with orphanin and opiate
3) Confidence 0.00 Published 2000 Journal Acta Pharmacol. Sin. Section Title Doc Link 11360685 Disease Relevance 0 Pain Relevance 0.34
AIM: To determine if endomorphin-1, -2 and nociceptin (orphanin FQ) bind to the mu 3 opiate receptor subtype or release nitric oxide as mu 3 selective ligands do.
mu 3 opiate receptor Binding (bind) of nociceptin associated with orphanin and opiate
4) Confidence 0.00 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11360685 Disease Relevance 0 Pain Relevance 0.31
Most significantly however, whilst the ORL1 and kappa-opioid receptors display high binding preference (KD 0.1 vs. 100 nM) for their respective endogenous ligands, nociceptin and dynorphin A, the O-K chimeric receptor binds both nociceptin and dynorphin A, with high affinity (KD < 1 nM).
O-K chimeric receptor Binding (binds) of nociceptin associated with dynorphin, orphanin, kappa opioid receptor and opioid
5) Confidence 0.00 Published 1998 Journal FEBS Lett. Section Abstract Doc Link 9607332 Disease Relevance 0 Pain Relevance 1.17

General Comments

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