INT7076

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 0.96
Pain Relevance 8.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Serbp1) plasma membrane (Serbp1) nucleus (Serbp1)
cytoplasm (Serbp1)
Anatomy Link Frequency
spinal cord 1
cerebral cortex 1
prefrontal 1
nervous system 1
Serbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 157 100.00 Very High Very High Very High
Opioid 65 100.00 Very High Very High Very High
agonist 34 100.00 Very High Very High Very High
opioid receptor 29 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
tolerance 44 99.52 Very High Very High Very High
Endogenous opioid 1 98.72 Very High Very High Very High
Inflammation 5 98.48 Very High Very High Very High
Spinal cord 2 97.52 Very High Very High Very High
Antinociceptive 35 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 98.48 Very High Very High Very High
Substance Withdrawal Syndrome 2 95.40 Very High Very High Very High
Functional Bowel Disorder 2 92.64 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 82.64 Quite High
Toxicity 1 74.00 Quite High
Reprotox - General 3 1 68.60 Quite High
Newborn Drug Withdrawal Syndrome 4 51.84 Quite High
Catatonia 2 39.96 Quite Low
Body Weight 11 25.72 Quite Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of single administration of morphine on G-protein mRNA level in the presence and absence of inflammation in the rat spinal cord.
Regulation (Effects) of G-protein mRNA in spinal cord associated with inflammation, spinal cord and morphine
1) Confidence 0.45 Published 2008 Journal Scand. J. Immunol. Section Title Doc Link 18052964 Disease Relevance 0.34 Pain Relevance 1.07
Differentiations in the Polish RDA coverage for energy and nutrients were observed in the studied group.
Regulation (Differentiations) of Polish RDA
2) Confidence 0.31 Published 2009 Journal Rocz Panstw Zakl Hig Section Abstract Doc Link 19803452 Disease Relevance 0.17 Pain Relevance 0.17
The morphine-induced changes in G-protein mRNA levels may reflect changes in gene expression and could result in changes in G-protein levels affecting signal transduction pathways in chronically treated animals.
Regulation (changes) of G-protein mRNA associated with morphine
3) Confidence 0.28 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11137853 Disease Relevance 0 Pain Relevance 0.48
Morphine-induced changes of G-protein mRNA levels were detected only in the prefrontal cortex.
Regulation (changes) of G-protein mRNA in prefrontal associated with morphine
4) Confidence 0.28 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11137853 Disease Relevance 0 Pain Relevance 0.50
We have utilized a reverse transcriptase-polymerase chain reaction (RT-PCR) methodology followed by enzymatic restriction analysis to detect changes in G-protein mRNA levels in morphine-treated rats.
Regulation (changes) of G-protein mRNA associated with morphine
5) Confidence 0.28 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11137853 Disease Relevance 0 Pain Relevance 0.40
Addition of diisopropylflurophophate (DFP) to the morphine infusion schedule inhibited the adaptive changes in M1 mRNA levels induced by morphine.
Regulation (changes) of M1 mRNA associated with morphine
6) Confidence 0.18 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10884554 Disease Relevance 0.10 Pain Relevance 1.06
Hippocampal samples derived from morphine-dependent rats exhibited no changes in M1 mRNA levels after the morphine infusion.
Neg (no) Regulation (changes) of M1 mRNA associated with morphine
7) Confidence 0.18 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10884554 Disease Relevance 0.08 Pain Relevance 1.01
Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.
Regulation (Effect) of protein mRNA in nervous system associated with agonist, enkephalin and opioid
8) Confidence 0.12 Published 1994 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8090073 Disease Relevance 0 Pain Relevance 0.47
The effect of long term opioid treatment on the steady-state level of G-protein mRNA (G alpha s, G alpha i-1 and G alpha i-2) was analyzed using an RNAase protection hybridization assay.
Spec (analyzed) Regulation (effect) of G-protein mRNA associated with opioid
9) Confidence 0.04 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1382177 Disease Relevance 0 Pain Relevance 0.50
Several reports provided possible mechanisms to explain the prenatally morphine-induced tolerance to morphine, including changes in opioid receptor density [17,27,28], intracellular cAMP levels [29], G protein mRNA levels [30], and expression of endogenous opioids [31].
Regulation (changes) of protein mRNA associated with endogenous opioid, tolerance, opioid receptor and morphine
10) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890660 Disease Relevance 0.19 Pain Relevance 1.51
Regulation of G-PROTEIN mRNA abundancy and cAMP accumulation after long-term opioid incubation in primary cultures of astroglia from the rat cerebral cortex.
Regulation (Regulation) of G-PROTEIN mRNA in cerebral cortex associated with cerebral cortex and opioid
11) Confidence 0.03 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1337944 Disease Relevance 0 Pain Relevance 0.40
Furthermore, long term opioid treatment induces alterations in glial G-protein mRNA levels.
Regulation (alterations) of G-protein mRNA associated with opioid
12) Confidence 0.03 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1337944 Disease Relevance 0 Pain Relevance 0.56

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