INT70760

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.23
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Actg2) cytoplasm (Actg2)
Anatomy Link Frequency
smooth muscle 5
macrophage 1
neuron 1
kidney 1
Actg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 82.84 Quite High
anesthesia 2 82.44 Quite High
abdominal pain 1 74.76 Quite High
cytokine 2 68.60 Quite High
fibrosis 1 68.08 Quite High
Chronic pancreatitis 2 66.00 Quite High
imagery 1 8.16 Low Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 32 99.76 Very High Very High Very High
Ureteral Obstruction 11 99.30 Very High Very High Very High
Apoptosis 4 97.96 Very High Very High Very High
Sarcoma 15 97.08 Very High Very High Very High
Endometrial Stromal Sarcoma 20 94.96 High High
Metastasis 5 94.64 High High
Abscess 5 91.84 High High
Suppuration 1 91.24 High High
Benign Tumor 1 89.72 High High
Solid Tumor 1 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Partial UUO delayed glomerular maturation and increased ipsilateral renal macrophage infiltration, alpha-smooth muscle actin and Sirius red staining.
Positive_regulation (increased) of alpha-smooth muscle actin in macrophage associated with ureteral obstruction
1) Confidence 0.48 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17107943 Disease Relevance 0.91 Pain Relevance 0.08
Early losartan treatment further increased alpha-smooth muscle actin and collagen in the obstructed kidney and induced apoptosis, macrophages, and collagen in the contralateral kidney.
Positive_regulation (increased) of alpha-smooth muscle actin in kidney associated with apoptosis
2) Confidence 0.48 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17442727 Disease Relevance 0.79 Pain Relevance 0.07
Immunohistochemistry showed that the characteristic clusters in chylous fluids were positive for alpha-smooth muscle actin.
Positive_regulation (positive) of alpha-smooth muscle actin in smooth muscle
3) Confidence 0.46 Published 2000 Journal Acta Cytol. Section Body Doc Link 11127739 Disease Relevance 0.07 Pain Relevance 0
Pressure increased the expression levels of alpha-smooth muscle actin, alpha(1)(I)-procollagen, and TGF-beta1 in PSCs.
Positive_regulation (increased) of alpha-smooth muscle actin in smooth muscle
4) Confidence 0.42 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.36 Pain Relevance 0.22
Tumor cells showed positive staining for vimentin and neuron-specific enolase but were negative for desmin, alpha-smooth muscle actin, and S-100 protein.
Positive_regulation (negative) of alpha-smooth muscle actin in neuron associated with cancer
5) Confidence 0.10 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9252861 Disease Relevance 1.89 Pain Relevance 0.08
Immunohistochemically, the neoplastic cells were strongly positive for vimentin, estrogen receptor and progesterone receptor but negative for alpha-smooth muscle actin, S-100 protein and CD34.
Positive_regulation (negative) of alpha-smooth muscle actin in smooth muscle
6) Confidence 0.07 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15818757 Disease Relevance 0.73 Pain Relevance 0.07
Immunohistochemically, myxoid tumor cells were positive for vimentin but not for alpha-smooth muscle actin, CD34, CD31, desmin, or S-100 protein.
Neg (not) Positive_regulation (positive) of alpha-smooth muscle actin in smooth muscle associated with cancer
7) Confidence 0.03 Published 2001 Journal Surg. Today Section Abstract Doc Link 11428615 Disease Relevance 0.72 Pain Relevance 0.08
The positive staining for CD10 and alpha-smooth muscle actin (alpha-SMA) in the absence of desmin expression may be indicative for a sarcoma of endometrial stromal origin.
Positive_regulation (staining) of alpha-smooth muscle actin in smooth muscle associated with sarcoma
8) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2925352 Disease Relevance 0.75 Pain Relevance 0

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