INT70775

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 8.65
Pain Relevance 8.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
microglia 8
neurons 4
neuronal 2
nerves 2
peripheral nerve 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 29 100.00 Very High Very High Very High
Central nervous system 19 99.92 Very High Very High Very High
Neuropathic pain 25 99.80 Very High Very High Very High
adenocard 21 99.66 Very High Very High Very High
Pain 20 99.54 Very High Very High Very High
Glutamate 25 99.48 Very High Very High Very High
nociceptor 14 99.26 Very High Very High Very High
Peripheral nerve injury 5 98.88 Very High Very High Very High
ischemia 12 98.76 Very High Very High Very High
allodynia 9 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 35 100.00 Very High Very High Very High
Nociception 28 100.00 Very High Very High Very High
Diabetes Mellitus 9 99.84 Very High Very High Very High
Neuropathic Pain 49 99.80 Very High Very High Very High
Cv Unclassified Under Development 8 98.76 Very High Very High Very High
Pain 16 97.44 Very High Very High Very High
Hyperalgesia 9 97.16 Very High Very High Very High
Death 1 94.72 High High
Coronary Heart Disease 4 93.76 High High
Neurodegenerative Disease 2 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflammatory cytokine interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cytolytic plasma membrane pore formation.
Positive_regulation (leads) of Positive_regulation (Activation) of P2X in pore associated with agonist and cytokine
1) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.39 Pain Relevance 0.39
The levels of P2X(2) and P2X(3) receptors mRNA were significantly increased in diabetic mice at 14 days after the intravenous injection of STZ.
Positive_regulation (increased) of Positive_regulation (increased) of P2X associated with diabetes mellitus
2) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 0.93 Pain Relevance 0.98
The levels of P2X(2) and P2X(3) receptors mRNA were significantly increased in diabetic mice at 14 days after the intravenous injection of STZ.
Positive_regulation (increased) of Positive_regulation (increased) of P2X associated with diabetes mellitus
3) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 0.93 Pain Relevance 0.99
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.
Positive_regulation (required) of Positive_regulation (upregulation) of P2X in peripheral nerve associated with pain, nervous system injury, neuropathic pain and peripheral nerve injury
4) Confidence 0.39 Published 2008 Journal Glia Section Title Doc Link 17918263 Disease Relevance 1.22 Pain Relevance 0.98
Using in vitro and in vivo models, we provide direct evidence that P2X(4)R stimulation leads to the release of BDNF from activated microglia and, most likely phosphorylation of the NR1 subunit of NMDA receptors in dorsal horn neurons of the spinal cord.
Positive_regulation (leads) of Positive_regulation (stimulation) of P2X in dorsal horn associated with nmda receptor, dorsal horn neuron and spinal cord
5) Confidence 0.37 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.78 Pain Relevance 0.81
We have previously shown that activation of the ATP-gated ion channel subtype P2X(4) receptors (P2X(4)Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain.
Positive_regulation (necessary) of Positive_regulation (activation) of P2X in microglia associated with nervous system injury, neuropathic pain and spinal cord
6) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.44 Pain Relevance 0.35
We have previously shown that activation of the ATP-gated ion channel subtype P2X(4) receptors (P2X(4)Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain.
Positive_regulation (necessary) of Positive_regulation (activation) of P2X in microglia associated with nervous system injury, neuropathic pain and spinal cord
7) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.44 Pain Relevance 0.35
We have previously shown that activation of the ATP-gated ion channel subtype P2X(4) receptors (P2X(4)Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain.
Positive_regulation (upregulated) of Positive_regulation (activation) of P2X in microglia associated with nervous system injury, neuropathic pain and spinal cord
8) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.43 Pain Relevance 0.35
We have previously shown that activation of the ATP-gated ion channel subtype P2X(4) receptors (P2X(4)Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain.
Positive_regulation (upregulated) of Positive_regulation (activation) of P2X in microglia associated with nervous system injury, neuropathic pain and spinal cord
9) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.43 Pain Relevance 0.35
Taken together, these data indicate that activation of P2X and P2Y receptors might be essential to the maintenance of melittin-induced primary thermal and mechanical hyperalgesia as well as on-going pain.
Spec (might) Positive_regulation (essential) of Positive_regulation (activation) of P2X associated with pain and hyperalgesia
10) Confidence 0.28 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18404374 Disease Relevance 1.12 Pain Relevance 0.72
Thus, activation of VR1 and P2X receptors selectively facilitated presynaptic glutamate release on different NTS neurons.
Positive_regulation (facilitated) of Positive_regulation (activation) of P2X in neurons associated with glutamate
11) Confidence 0.23 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15152030 Disease Relevance 0 Pain Relevance 0.49
Activation of P2X mediates AA production via stimulation of PLA2 [46].
Positive_regulation (mediates) of Positive_regulation (Activation) of P2X
12) Confidence 0.19 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.43 Pain Relevance 0.29
Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor.
Positive_regulation (enhances) of Positive_regulation (activation) of p2X associated with nociception, adenocard and nociceptor
13) Confidence 0.18 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9253943 Disease Relevance 0.10 Pain Relevance 0.49
Increased activation of P2X receptors could contribute to ischemia-evoked glutamate release and thereby to glutamatergic excitotoxicity and resultant neuronal death; therefore, inhibition of these receptors could be a promising approach to treat ischemia-related neurodegenerative diseases.
Positive_regulation (Increased) of Positive_regulation (activation) of P2X in neuronal associated with glutamate, ischemia, neurodegenerative disease and death
14) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 1.01 Pain Relevance 0.54
It is concluded that the neurogenic arterial contraction is induced mainly by ATP via stimulation of P2X purinoceptors, and that the relaxation induced by electrical stimulation or a low concentration of nicotine is mediated by nitric oxide (NO) released from perivascular nerves.
Positive_regulation (induced) of Positive_regulation (stimulation) of P2X in nerves associated with nicotine
15) Confidence 0.04 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726629 Disease Relevance 0 Pain Relevance 0.41
ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors.
Positive_regulation (increases) of Positive_regulation (activation) of P2X in neurons
16) Confidence 0.03 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 16973929 Disease Relevance 0 Pain Relevance 0

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