INT70776

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 62
Total Number 62
Disease Relevance 32.55
Pain Relevance 30.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
neurons 7
microglia 5
peripheral nerve 5
spinal cord 4
nerve 3
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 124 100.00 Very High Very High Very High
Pain 97 100.00 Very High Very High Very High
gABA 80 100.00 Very High Very High Very High
Lasting pain 16 99.92 Very High Very High Very High
Neuropathic pain 127 99.80 Very High Very High Very High
Spinal cord 160 99.68 Very High Very High Very High
Dorsal horn 90 99.68 Very High Very High Very High
adenocard 135 99.52 Very High Very High Very High
Neurotransmitter 184 99.34 Very High Very High Very High
Inflammation 63 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 73 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 15 99.92 Very High Very High Very High
Diabetes Mellitus 23 99.84 Very High Very High Very High
Skin Cancer 4 99.84 Very High Very High Very High
Nervous System Injury 111 99.82 Very High Very High Very High
Neuropathic Pain 205 99.80 Very High Very High Very High
Nociception 155 99.48 Very High Very High Very High
Coronary Heart Disease 24 99.24 Very High Very High Very High
INFLAMMATION 72 99.20 Very High Very High Very High
Targeted Disruption 56 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The levels of P2X(2) and P2X(3) receptors mRNA were significantly increased in diabetic mice at 14 days after the intravenous injection of STZ.
Positive_regulation (increased) of P2X associated with diabetes mellitus
1) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 0.93 Pain Relevance 0.99
The levels of P2X(2) and P2X(3) receptors mRNA were significantly increased in diabetic mice at 14 days after the intravenous injection of STZ.
Positive_regulation (increased) of P2X associated with diabetes mellitus
2) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 0.93 Pain Relevance 0.98
These results suggest that the upregulation of P2X(2), P2X(3) and/or P2X(2/3) receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice.
Positive_regulation (upregulation) of P2X in neurons associated with allodynia and diabetes mellitus
3) Confidence 0.62 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 1.07 Pain Relevance 0.94
P2X(3)-positive neurons were significantly increased in melanoma-bearing mice.
Positive_regulation (increased) of P2X in neurons associated with skin cancer
4) Confidence 0.61 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.10 Pain Relevance 0.43
Microglia play a key role in neuropathic pain and show phagocytosis through nucleotide-evoked activation of P2X(4) and P2Y(6) receptors, respectively.
Positive_regulation (activation) of P2X in Microglia associated with neuropathic pain
5) Confidence 0.58 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697046 Disease Relevance 0.10 Pain Relevance 0.10
These results suggest that the upregulation of P2X(2), P2X(3) and/or P2X(2/3) receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice.
Positive_regulation (upregulation) of P2X in neurons associated with allodynia and diabetes mellitus
6) Confidence 0.54 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 1.07 Pain Relevance 0.93
These results suggest that the upregulation of P2X(2), P2X(3) and/or P2X(2/3) receptor in DRG neurons is associated with mechanical allodynia in STZ-induced diabetic mice.
Positive_regulation (upregulation) of P2X in neurons associated with allodynia and diabetes mellitus
7) Confidence 0.54 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383439 Disease Relevance 1.07 Pain Relevance 0.94
Together, our data suggest that a subset of spontaneous and evoked PSCs arise from the concurrent activation of both GABA(A) and P2X receptors.
Positive_regulation (activation) of P2X associated with gaba
8) Confidence 0.51 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077176 Disease Relevance 0 Pain Relevance 0.38
Once in the extracellular fluids, they are rapidly degraded by ectonucleotidases, such as CD39, that play a key role in neutralizing the platelet aggregatory action of adenosine diphosphate (ADP), and act on two families of receptors: the ionotropic P2X receptors and the G-protein-coupled P2Y receptors.
Positive_regulation (act) of P2X in platelet associated with adenocard
9) Confidence 0.49 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852217 Disease Relevance 0.20 Pain Relevance 0.10
Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflammatory cytokine interleukin-1beta (IL-1beta), and following prolonged agonist exposure, cytolytic plasma membrane pore formation.
Positive_regulation (Activation) of P2X in pore associated with agonist and cytokine
10) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16982702 Disease Relevance 0.38 Pain Relevance 0.39
Therefore, there was no evidence for the activation of ionotropic P2X receptors under the present conditions.
Positive_regulation (activation) of P2X
11) Confidence 0.49 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927203 Disease Relevance 0 Pain Relevance 0.29
We have previously shown that activation of the ATP-gated ion channel subtype P2X(4) receptors (P2X(4)Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain.
Positive_regulation (activation) of P2X in microglia associated with nervous system injury, neuropathic pain and spinal cord
12) Confidence 0.47 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.42 Pain Relevance 0.34
Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury.
Positive_regulation (upregulation) of P2X in spinal cord associated with neuralgia, nervous system injury, neuropathic pain and spinal cord
13) Confidence 0.47 Published 2008 Journal Glia Section Title Doc Link 18240312 Disease Relevance 0.64 Pain Relevance 0.74
We have previously shown that activation of the ATP-gated ion channel subtype P2X(4) receptors (P2X(4)Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain.
Positive_regulation (activation) of P2X in microglia associated with nervous system injury, neuropathic pain and spinal cord
14) Confidence 0.47 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.42 Pain Relevance 0.34
Furthermore, intrathecal administration of fibronectin in normal rats increased the level of P2X(4)R protein in the spinal cord and produced tactile allodynia.
Positive_regulation (increased) of P2X in spinal cord associated with brush evoked pain, spinal cord and intrathecal
15) Confidence 0.47 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.88 Pain Relevance 0.85
Seven P2X receptor subunits (P2X(1-7)) are widely distributed in excitable and nonexcitable cells of vertebrates.
Positive_regulation (distributed) of P2X
16) Confidence 0.47 Published 2009 Journal Annu. Rev. Physiol. Section Abstract Doc Link 18851707 Disease Relevance 0.25 Pain Relevance 0.17
Activation of P2X(7) receptors provides an inflammatory stimulus, and P2X(7) receptor-deficient mice have substantially attenuated inflammatory responses, including models of neuropathic and chronic inflammatory pain.
Positive_regulation (Activation) of P2X associated with inflammatory response, ipn, neuropathic pain and inflammatory stimuli
17) Confidence 0.46 Published 2010 Journal FASEB J. Section Abstract Doc Link 19812374 Disease Relevance 0.82 Pain Relevance 0.50
Although previous studies describe the up-regulation of purinergic P2X(3) receptors expressed at peripheral nociceptive fibers in experimental painful neoplastic processes, the analgesic efficacy of P2X(3) receptor antagonists has not been tested in these settings.
Positive_regulation (up-regulation) of P2X associated with nociception, pain, antagonist, analgesic and neoplastic processes
18) Confidence 0.45 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19765404 Disease Relevance 0.62 Pain Relevance 0.60
Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models.
Positive_regulation (antagonizes) of P2X associated with pain and analgesic
19) Confidence 0.44 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18565509 Disease Relevance 0.36 Pain Relevance 0.60
Microglia play a key role in neuropathic pain, chemotaxis and phagocytosis through nucleotide-evoked activation of P2X(4), P2Y(12) and P2Y(6) receptors, respectively.
Positive_regulation (activation) of P2X in Microglia associated with neuropathic pain
20) Confidence 0.41 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18563292 Disease Relevance 0.10 Pain Relevance 0.10

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