INT70781

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Context Info
Confidence 0.54
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.51
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dpyd) oxidoreductase activity (Dpyd) cytoplasm (Dpyd)
Anatomy Link Frequency
urine 1
Dpyd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 10 98.44 Very High Very High Very High
Pain 6 81.04 Quite High
imagery 2 75.00 Quite High
Eae 21 67.92 Quite High
palliative 2 59.00 Quite High
backache 1 52.56 Quite High
COX2 4 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
noradrenaline 1 5.00 Very Low Very Low Very Low
shoulder pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 4 98.86 Very High Very High Very High
Hypercalcemia 7 96.12 Very High Very High Very High
Cancer 8 95.44 Very High Very High Very High
INFLAMMATION 4 92.68 High High
Pressure And Volume Under Development 1 90.20 High High
Sacroiliitis 1 89.48 High High
Disease Progression 1 88.36 High High
Rickets 3 86.48 High High
Sunburn 1 82.16 Quite High
Pain 6 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was demonstrated that elevated dihydropyrimidine dehydrogenase (DPD) and COX-2 activities influence the response to 5-fluorouracil (5-FU).
Positive_regulation (elevated) of DPD
1) Confidence 0.54 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19661321 Disease Relevance 0.34 Pain Relevance 0.45
It was demonstrated that elevated dihydropyrimidine dehydrogenase (DPD) and COX-2 activities influence the response to 5-fluorouracil (5-FU).
Positive_regulation (elevated) of dihydropyrimidine dehydrogenase
2) Confidence 0.54 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19661321 Disease Relevance 0.34 Pain Relevance 0.45
Clinical and radiological evaluation revealed occurrence of new bone metastases in six patients (Group II), with concurrent significant increase in concentrations of urine DPD and Ca+2 (p = 0.006 for Ca+2 and p = 0.009 for DPD, respectively).
Positive_regulation (increase) of DPD in urine associated with metastasis
3) Confidence 0.40 Published 2007 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 18365552 Disease Relevance 0.47 Pain Relevance 0.06
However, the patients who did not undergo 89Sr-chloride therapy exhibited a two-fold increase in PYD and a four-fold increase in DPD above controls during the interval.
Positive_regulation (increase) of DPD
4) Confidence 0.31 Published 1997 Journal J. Nucl. Med. Section Body Doc Link 9255144 Disease Relevance 0.05 Pain Relevance 0
Because the urinary Dpd levels were higher in the OVX-M and OVX-D groups after ovariectomy than in the normal group, it was confirmed that bone resorption was enhanced by ovariectomy.
Positive_regulation (higher) of Dpd associated with hypercalcemia
5) Confidence 0.31 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810356 Disease Relevance 0.50 Pain Relevance 0.14
A 7-fold increase in free urinary DPD and a 17-fold increase in bone-specific alkaline phosphatase (bone-AP) were also measured.
Positive_regulation (increase) of DPD
6) Confidence 0.18 Published 2001 Journal Int. J. Biol. Markers Section Abstract Doc Link 11471897 Disease Relevance 0.81 Pain Relevance 0.16

General Comments

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