INT70790

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Context Info
Confidence 0.18
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc14a2) plasma membrane (Slc14a2)
Slc14a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 1 98.96 Very High Very High Very High
Painful diabetic neuropathy 3 98.52 Very High Very High Very High
B1 receptor 2 98.32 Very High Very High Very High
antagonist 3 88.80 High High
Hyperalgesia 5 87.68 High High
adenocard 1 83.60 Quite High
Bile 1 83.48 Quite High
guanethidine 1 78.32 Quite High
tetrodotoxin 4 76.04 Quite High
Thermal hyperalgesia 1 69.36 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 9 100.00 Very High Very High Very High
Diabetic Neuropathy 3 98.52 Very High Very High Very High
Hyperalgesia 6 87.68 High High
Nociception 1 74.40 Quite High
Muscular Atrophy 1 60.32 Quite High
Hyperglycemia 1 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior administration of N(G)-nitro-L-arginine methyl ester (L-NAME), as well as indomethacin, significantly attenuated the reduction of acid secretion by TC and acid secretion was even increased in the presence of L-NAME.
Positive_regulation (increased) of L-NAME
1) Confidence 0.18 Published 2000 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 10759219 Disease Relevance 0 Pain Relevance 0.07
Several neurovascular systems are activated in T1D, including the inducible bradykinin (BK) B1 receptor (BKB1-R) subtype.
Positive_regulation (activated) of T1D associated with diabetes mellitus, b1 receptor and bradykinin
2) Confidence 0.10 Published 2005 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 16141788 Disease Relevance 1.30 Pain Relevance 0.76
This potentiation was accompanied by an increase in DT tC-1 to 175.6 +/- 7%.
Positive_regulation (increase) of tC-1
3) Confidence 0.04 Published 1997 Journal Exp. Physiol. Section Abstract Doc Link 9257109 Disease Relevance 0.06 Pain Relevance 0.20
Increasing the L-NAME concentration to 1 mM had no additional inhibitory effect.
Positive_regulation (Increasing) of L-NAME
4) Confidence 0.00 Published 1999 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 10190041 Disease Relevance 0 Pain Relevance 0.13

General Comments

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