INT70800

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.18
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
A7r5 4
lung 2
body 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 97 100.00 Very High Very High Very High
bradykinin 142 99.98 Very High Very High Very High
qutenza 4 97.52 Very High Very High Very High
Opioid 1 97.40 Very High Very High Very High
agonist 118 96.84 Very High Very High Very High
Dopamine 4 96.08 Very High Very High Very High
dorsal root ganglion 1 95.92 Very High Very High Very High
antagonist 10 95.00 High High
Nicotine 7 94.48 High High
Clonidine 2 93.92 High High
Disease Link Frequency Relevance Heat
Lung Cancer 4 99.84 Very High Very High Very High
Apoptosis 8 99.28 Very High Very High Very High
Cancer 28 98.80 Very High Very High Very High
Cervical Cancer 1 95.36 Very High Very High Very High
Ganglion Cysts 1 94.96 High High
Insulin Resistance 2 84.40 Quite High
INFLAMMATION 10 82.80 Quite High
Hyperlipidemia 2 81.36 Quite High
Increased Venous Pressure Under Development 10 78.72 Quite High
Hyperalgesia 3 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of PKC activation was abolished in the presence of bupivacaine.
Negative_regulation (abolished) of Positive_regulation (activation) of PKC
1) Confidence 0.34 Published 2006 Journal Br J Anaesth Section Body Doc Link 16299047 Disease Relevance 0 Pain Relevance 0
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy.
Negative_regulation (inhibition) of Positive_regulation (activity) of PKC in lung associated with kinase c, lung cancer, cancer, nicotine, apoptosis and opioid
2) Confidence 0.32 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 0.95 Pain Relevance 0.53
We found that BK lowered the threshold temperature for activation of VR1 currents in HEK cells down to well below the physiological body temperature in a concentration-dependent manner through PKC activation.
Negative_regulation (lowered) of Positive_regulation (activation) of PKC in body associated with kinase c and bradykinin
3) Confidence 0.31 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12091579 Disease Relevance 0.33 Pain Relevance 1.31
However, FPCS (2%)-induced activation of PKC in A7r5 cells and HAOSMC could only be blocked by 61 and 19% by BC (1 microM for A7r5 cells and 0.1 microM for HAOSMC), respectively.
Negative_regulation (blocked) of Positive_regulation (activation) of PKC in A7r5 associated with kinase c
4) Confidence 0.20 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9258405 Disease Relevance 0.33 Pain Relevance 0.64
Importantly, we demonstrated that activation of PKC-epsilon caused internalization of K(ATP) channels, the effect that was blocked by depletion of cholesterol with methyl-beta-cyclodextrin, expression of dominant-negative dynamin mutant K44E, or knockdown of caveolin-1 with small interfering RNA.
Negative_regulation (blocked) of Positive_regulation (activation) of PKC associated with kinase c
5) Confidence 0.20 Published 2008 Journal Hypertension Section Abstract Doc Link 18663158 Disease Relevance 0.21 Pain Relevance 0.46
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Negative_regulation (regulation) of Positive_regulation (activation) of PKC associated with kinase c
6) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0.48
These results indicate that activation of PKC significantly inhibits ATP mediated Ca2+ signaling and reduces resensitization of the response to ATP.
Negative_regulation (inhibits) of Positive_regulation (activation) of PKC associated with kinase c
7) Confidence 0.15 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.44
These results indicate that activation of PKC significantly inhibits ATP mediated Ca2+ signaling and reduces resensitization of the response to ATP.
Negative_regulation (reduces) of Positive_regulation (activation) of PKC associated with kinase c
8) Confidence 0.15 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.44
The PMA-induced stimulation of protein kinase C (PKC), a positive regulator of mitogenesis, could be completely blocked in A7r5 cells and HAOSMC by 1 and 0.1 microM BC, respectively.
Negative_regulation (blocked) of Positive_regulation (stimulation) of PKC in A7r5 associated with kinase c
9) Confidence 0.14 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9258405 Disease Relevance 0.28 Pain Relevance 0.68
328 was blocked by pre-incubation with the PKC inhibitor GF 109203X or by mutation of Ser145 within IC2 to generate TPS145A,?
Negative_regulation (pre) of Positive_regulation (incubation) of PKC
10) Confidence 0.11 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.18

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