INT70814

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Context Info
Confidence 0.56
First Reported 1997
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 40
Total Number 44
Disease Relevance 13.36
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
T cells 5
macrophages 2
nerve 2
thymocytes 2
plasma 1
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 34 99.76 Very High Very High Very High
antagonist 37 99.66 Very High Very High Very High
cytokine 367 99.52 Very High Very High Very High
Morphine 46 99.50 Very High Very High Very High
analgesia 7 98.38 Very High Very High Very High
Cannabinoid 138 98.00 Very High Very High Very High
drug abuse 2 96.84 Very High Very High Very High
antinociception 4 94.84 High High
Potency 10 94.80 High High
cocaine 3 94.32 High High
Disease Link Frequency Relevance Heat
Infection 329 99.92 Very High Very High Very High
Inflammatory Bowel Disease 23 99.76 Very High Very High Very High
Nervous System Injury 8 99.56 Very High Very High Very High
Cancer 222 99.40 Very High Very High Very High
Necrosis 15 99.04 Very High Very High Very High
Targeted Disruption 66 98.98 Very High Very High Very High
Sprains And Strains 54 97.08 Very High Very High Very High
Systemic Lupus Erythematosus 121 96.98 Very High Very High Very High
Drug Dependence 5 96.84 Very High Very High Very High
Catalepsy 4 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, these studies also suggest that inhibition of interleukin-2 is mediated by a PPARgamma, which is activated by a cyclooxygenase-2 metabolite of anandamide.
Negative_regulation (inhibition) of interleukin-2
1) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0 Pain Relevance 0.04
In the present studies, we show that anandamide caused a concentration-dependent inhibition of interleukin-2 in primary splenocytes.
Negative_regulation (inhibition) of interleukin-2
2) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0.19 Pain Relevance 0.19
The CB1 and CB2 antagonists, SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorphenyl)-4-methyl-H-pyrazole-3 carboxyamidehydrochloride] and SR144528 [N-[(1S)-endo-1,3,3,-trimethylbicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide], when used in combination, did not antagonize the inhibition of interleukin-2 by anandamide.
Negative_regulation (inhibition) of interleukin-2 associated with antagonist
3) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0.16 Pain Relevance 0.16
The inhibition of interleukin-2 by anandamide and arachidonic acid was partially reversed by pretreatment with the nonspecific cyclooxygenase inhibitors, flurbiprofen and piroxicam.
Negative_regulation (inhibition) of interleukin-2
4) Confidence 0.56 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15284281 Disease Relevance 0.11 Pain Relevance 0.12
When compared to control cultures, morphine-treated thymocytes showed decreased steady-state levels of bioactive IL-2 and IL-2 mRNA.
Negative_regulation (decreased) of IL-2 in thymocytes associated with morphine
5) Confidence 0.55 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
After 7 days of treatment, when mice were tolerant to delta9-THC-induced analgesia, these functional parameters were strongly inhibited and there was a persistent reduction in IL-2 and IFNgamma.
Negative_regulation (reduction) of IL-2 associated with analgesia
6) Confidence 0.45 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9916880 Disease Relevance 0 Pain Relevance 0.10
The analgesic effect of IL-2 is probably mediated by opiate receptor.


Negative_regulation (effect) of IL-2
7) Confidence 0.43 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 17715020 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).
Spec (investigate) Negative_regulation (effect) of IL-2 in nerve associated with nervous system injury and analgesic
8) Confidence 0.43 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Abstract Doc Link 17715020 Disease Relevance 0.17 Pain Relevance 0.17
RESULTS: IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively.
Negative_regulation (effect) of IL-2
9) Confidence 0.43 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Body Doc Link 17715020 Disease Relevance 0.09 Pain Relevance 0
OBJECTIVE: To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).
Spec (investigate) Negative_regulation (effect) of interleukin-2 in nerve associated with nervous system injury and analgesic
10) Confidence 0.43 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Abstract Doc Link 17715020 Disease Relevance 0.17 Pain Relevance 0.17
CONCLUSIONS: The results demonstrate for the first time that a combination of viral infection and constitutive expression of IL-2, but not IFN-gamma or IL-4, can result in demyelination and visual impairment in the optic nerves of ocularly infected mice.


Negative_regulation (combination) of IL-2 in optic nerves
11) Confidence 0.42 Published 2009 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19234357 Disease Relevance 0.06 Pain Relevance 0
When compared to control cultures, morphine-treated thymocytes showed decreased steady-state levels of bioactive IL-2 and IL-2 mRNA.
Negative_regulation (decreased) of IL-2 in thymocytes associated with morphine
12) Confidence 0.40 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
The reduced IL-2 concentration and reduced transcript levels correlated well with a decreased rate of synthesis of IL-2 mRNA as determined by nuclear runoff assays.
Negative_regulation (reduced) of IL-2
13) Confidence 0.40 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
In this model, the exposure to morphine (25 mg/kg, 5 days before, during and 5 days after inoculation with the yeast) significant decreased IL-2 and IL-4 levels, while secretion of IFN-gamma was unaltered.
Negative_regulation (decreased) of IL-2 associated with morphine
14) Confidence 0.38 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.31 Pain Relevance 0.58
Moreover, splenocytes and macrophages isolated from paeonol-treated HepA tumor-bearing mice produced higher levels of IL-2 and TNF-alpha in response to concanavalin A and lipopolysaccharide stimulation, respectively, compared to these isolated from non-treated HepA tumor-bearing mice.
Negative_regulation (levels) of IL-2 in macrophages associated with cancer
15) Confidence 0.36 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18329639 Disease Relevance 1.42 Pain Relevance 0.10
We had previously shown that chronic morphine treatment in vivo and in vitro decreases IL-2 and IFNgamma (Th1) protein levels and increases IL-4 and IL-5 (Th2) protein levels in a time-dependent manner.
Negative_regulation (decreases) of IL-2 associated with morphine
16) Confidence 0.31 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.10 Pain Relevance 0.53
In addition in this paper, we show that chronic morphine treatment resulted in a decrease in IFNgamma and IL-2 mRNA and an increase in IL-4 and IL-5 mRNA accumulation in murine splenocytes.
Negative_regulation (decrease) of IL-2 mRNA associated with morphine
17) Confidence 0.31 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.67
In this study, we observed that the amounts of IL-2 and IFN-?
Negative_regulation (amounts) of IL-2
18) Confidence 0.29 Published 2005 Journal BMC Complement Altern Med Section Body Doc Link PMC1084244 Disease Relevance 0.10 Pain Relevance 0.08
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Negative_regulation (decreased) of IL-2 in spleen
19) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.17
[12], IL-2 [3], IL-6 [12], ACTH [35], corticosterone [3], as well as a decreased plasma level of ?
Negative_regulation (decreased) of IL-2 in plasma
20) Confidence 0.20 Published 2007 Journal Infect Agent Cancer Section Body Doc Link PMC2211456 Disease Relevance 0.75 Pain Relevance 0

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