INT70815

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.37
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
B-cell 2
thymocytes 2
T cells 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 95 100.00 Very High Very High Very High
Morphine 8 99.98 Very High Very High Very High
rheumatoid arthritis 6 72.32 Quite High
agonist 3 50.00 Quite Low
Opioid 1 49.00 Quite Low
Inflammation 46 48.40 Quite Low
antagonist 2 44.56 Quite Low
Infliximab 1 28.48 Quite Low
Arthritis 5 10.72 Low Low
addiction 1 8.56 Low Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 52 95.04 Very High Very High Very High
Renal Disease 22 87.96 High High
Infection 5 81.96 Quite High
Proteinuria 3 78.16 Quite High
Rheumatoid Arthritis 6 72.32 Quite High
Diabetes Mellitus 2 71.12 Quite High
Autoimmune Disease 6 70.36 Quite High
Hirsutism 1 61.84 Quite High
Gingival Hypertrophy 1 61.12 Quite High
Targeted Disruption 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes.
Negative_regulation (inhibits) of Positive_regulation (activation) of IL-2 in thymocytes associated with morphine
1) Confidence 0.40 Published 1997 Journal Cell. Immunol. Section Title Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.57
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Negative_regulation (decreased) of Positive_regulation (activation) of IL-2 in T cells
2) Confidence 0.38 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.21 Pain Relevance 0.04
Panels A and B in Figure 3 show the concentrations of the Th1 cytokines, IL-2 and IFN-?
Negative_regulation (show) of Positive_regulation (concentrations) of IL-2 associated with cytokine
3) Confidence 0.13 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.09
Sirolimus (also known as rapamycin), a newer immunosuppressive drug, inhibits the mammalian target of rapamycin (mTOR) pathway with the result of a blockade of T- and B-cell activation to IL-2.
Negative_regulation (inhibits) of Positive_regulation (activation) of IL-2 in B-cell
4) Confidence 0.05 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 1.16 Pain Relevance 0.07

General Comments

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