INT70816

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 13.00
Pain Relevance 11.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
brain 2
hypothalamus 2
neurons 2
thymocytes 2
striatum 1
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 103 100.00 Very High Very High Very High
Glutamate 26 100.00 Very High Very High Very High
Dorsal horn 27 99.98 Very High Very High Very High
Enkephalin 12 99.98 Very High Very High Very High
qutenza 20 99.48 Very High Very High Very High
Inflammation 128 99.36 Very High Very High Very High
Hippocampus 21 99.32 Very High Very High Very High
medulla 31 99.16 Very High Very High Very High
agonist 32 99.02 Very High Very High Very High
cytokine 64 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 264 100.00 Very High Very High Very High
Stress 59 100.00 Very High Very High Very High
Hypersensitivity 7 100.00 Very High Very High Very High
Nociception 53 99.50 Very High Very High Very High
INFLAMMATION 128 99.36 Very High Very High Very High
Apoptosis 25 99.28 Very High Very High Very High
Overdose 48 99.20 Very High Very High Very High
Aids-related Complex 217 98.82 Very High Very High Very High
Pain 70 98.64 Very High Very High Very High
Injury 17 98.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vagotomy selectively decreased KA-evoked Fos in the NTS while sparing that in other brain areas.
Negative_regulation (decreased) of Fos in brain
1) Confidence 0.58 Published 2003 Journal Pain Section Abstract Doc Link 12620595 Disease Relevance 0.97 Pain Relevance 0.91
Of note, ZOL decreased the ASIC1a mRNA expression and c-Fos.
Negative_regulation (decreased) of c-Fos
2) Confidence 0.57 Published 2006 Journal Bone Section Abstract Doc Link 16769263 Disease Relevance 1.47 Pain Relevance 0.96
Furthermore, the analysis by real-time RT-PCR also revealed a down-regulation of cFos mRNA in the diffuser-treated eyes after 30 min and even after 6+6 h.
Negative_regulation (regulation) of cFos mRNA in eyes
3) Confidence 0.42 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.14 Pain Relevance 0.04
Subsequent studies showed that morphine treatment affected transcriptional control elements of the IL-2 promoter by inhibiting the synthesis of a specific trans-activating nuclear factor, c-Fos. c-Fos mRNA levels measured by semiquantitative RT-PCR were significantly decreased in thymocytes following treatment with morphine and activation with PHA and IL-1.
Negative_regulation (decreased) of c-Fos in thymocytes associated with morphine
4) Confidence 0.41 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.71
Immunohistochemical experiments based on the revelation of c-Fos positive nuclei following PVN stimulation (Figure 4) were in line with our electrophysiological results.
Negative_regulation (revelation) of c-Fos
5) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430948 Disease Relevance 0.13 Pain Relevance 0.20
The novel specific 5-hydroxytryptamine1F agonist LY 344864 (0.1 and 1 mg/kg, i.p.) significantly decreased the c-fos LI within the Sp5C as well.
Negative_regulation (decreased) of c-fos associated with agonist
6) Confidence 0.41 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12110114 Disease Relevance 0.09 Pain Relevance 0.73
Importantly, the number of c-Fos/NPY–positive cells, but not POMC cells, was reduced to 10% in response to intragastric glucose.
Negative_regulation (reduced) of c-Fos
7) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.49 Pain Relevance 0.08
Expression of Arc/Arg3.1 mRNA following nociceptive stimulation occurs in a subset of c-Fos labeled neurons and is intensity dependent
Negative_regulation (subset) of c-Fos in neurons associated with nociception and aids-related complex
8) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.93 Pain Relevance 0.21
Since c-fos/AP-1 regulates the expression of numerous inflammatory cytokines and MMPs/TIMPs via promoter AP-1 binding motif [59,60], suppression of c-fos may provide a possible mechanism whereby MMPs/TIMPs and possibly cytokine levels are inhibited.
Negative_regulation (suppression) of c-fos associated with inflammation and cytokine
9) Confidence 0.41 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.21 Pain Relevance 0.24
We also show that while the degree of Fos staining in the NTS of allergic mice was only diminished by neonatal capsaicin, it was completely blocked in the PVN.
Negative_regulation (diminished) of Fos in PVN associated with qutenza and hypersensitivity
10) Confidence 0.41 Published 2004 Journal Brain Res. Section Abstract Doc Link 15120595 Disease Relevance 0.53 Pain Relevance 0.73
Moreover, reduction of c-Fos activity by antisense oligonucleotides is able to prevent growth factor-deprived lymphoid cells from undergoing apoptosis.
Negative_regulation (reduction) of Fos associated with apoptosis
11) Confidence 0.41 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 0.77 Pain Relevance 0.05
[D-Ala2, D-Leu5]enkephalin blocks the methamphetamine-induced c-fos mRNA increase in mouse striatum.
Negative_regulation (blocks) of c-fos mRNA in striatum associated with enkephalin
12) Confidence 0.37 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10082218 Disease Relevance 0 Pain Relevance 0.37
In contrast, mice lacking Fos show an attenuated phase response curve to light [5], suggesting that this gene is involved in the signal transduction mechanism for conveying photic information to the molecular clock mechanism.
Negative_regulation (lacking) of Fos
13) Confidence 0.33 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.17 Pain Relevance 0.03
However, tissue injury-evoked persistent pain behavior, inflammation of the hindpaw, and ipsilateral dorsal horn Fos immunoreactivity was significantly reduced in the mutant mice, as was plasma extravasation induced by intradermal injection of capsaicin into the paw.
Negative_regulation (reduced) of Fos in paw associated with pain, qutenza, inflammation, lasting pain, injury and dorsal horn
14) Confidence 0.30 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295392 Disease Relevance 1.46 Pain Relevance 0.94
An identical set of mice was used for determination of Fos immunoreactivity in NTS, PVN, and DMH.
Negative_regulation (determination) of Fos associated with medulla
15) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.10
Representative photomicrographs and the corresponding counts of Fos-like immunoreactive neurons in the DH are shown in Fig. 4.
Negative_regulation (shown) of Fos in neurons associated with spinal dorsal horn
16) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.29
Increased expression of c-Fos was markedly reduced by treatment with MK-801 (5 ?
Negative_regulation (reduced) of Fos
17) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0 Pain Relevance 0.33
However, anti-NGF treatment did not reduce p-ERK and c-Fos expression at 20 and 90 min, respectively, following fracture.
Neg (not) Negative_regulation (reduce) of c-Fos
18) Confidence 0.18 Published 2007 Journal Pain Section Abstract Doc Link 17693023 Disease Relevance 0.93 Pain Relevance 0.94
A volume of 0.1 ml provided bioluminescence images of the skin, brain, and internal structures in adult CMV::luc and fos::luc mice after an overdose with pentobarbital (Fig. 1, 2).
Negative_regulation (provided) of fos in skin associated with cytomegalovirus infection and overdose
19) Confidence 0.16 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.60 Pain Relevance 0.08
Many immediate early genes such as Fos, Jun and Early Growth Response isoforms were down-regulated although others associated with stress such as glucocorticoid responsive genes were up-regulated.
Negative_regulation (regulated) of Fos associated with stress
20) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2939656 Disease Relevance 0.45 Pain Relevance 0.06

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