INT70817

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.25
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2)
Anatomy Link Frequency
thymocytes 2
T-cell 2
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 99.46 Very High Very High Very High
cytokine 93 97.76 Very High Very High Very High
Arthritis 27 64.48 Quite High
Opioid 1 30.88 Quite Low
Bile 6 30.60 Quite Low
antagonist 4 30.56 Quite Low
Inflammation 42 5.00 Very Low Very Low Very Low
rheumatoid arthritis 34 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphoproliferative Disease 1 81.96 Quite High
Arthritis 29 64.48 Quite High
Sprains And Strains 27 53.32 Quite High
INFLAMMATION 46 33.76 Quite Low
Disease 18 28.80 Quite Low
Rheumatoid Arthritis 34 5.00 Very Low Very Low Very Low
Autoimmune Disease 17 5.00 Very Low Very Low Very Low
Cancer 11 5.00 Very Low Very Low Very Low
Infection 9 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared to control cultures, morphine-treated thymocytes showed decreased steady-state levels of bioactive IL-2 and IL-2 mRNA.
Negative_regulation (decreased) of Transcription (levels) of IL-2 in thymocytes associated with morphine
1) Confidence 0.40 Published 1997 Journal Cell. Immunol. Section Abstract Doc Link 9259765 Disease Relevance 0 Pain Relevance 0.50
By day 15, both IL-2 and IL-2 receptor gene transcription had decreased with only the high dose samples remaining significantly different from the control (Fig. 2A and 2B).
Negative_regulation (decreased) of Transcription (transcription) of IL-2
2) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.08
IL-2 and IL-2 receptor gene transcription
Negative_regulation (receptor) of Transcription (transcription) of IL-2
3) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.05 Pain Relevance 0.13
IL-2 and IL-2 receptor gene transcription
Negative_regulation (receptor) of Transcription (transcription) of IL-2
4) Confidence 0.27 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.05 Pain Relevance 0.13
Recently, Anandasabapathy et al. have identified a new gene named GRAIL (gene related to anergy in lymphocytes).45 They have demonstrated that retrovirally transduced T-cell hybridomas that expressed GRAIL showed a blockade in Il-2 transcription, and CD4+CD25+ Treg cells also express GRAIL after activation (Ref. 46, and unpublished data).
Negative_regulation (blockade) of Transcription (transcription) of Il-2 in T-cell
5) Confidence 0.12 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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