INT7082

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 180
Total Number 180
Disease Relevance 64.66
Pain Relevance 31.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
plasma 14
placenta 14
deciduas 10
hypothalamus 7
cervix 7
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 781 100.00 Very High Very High Very High
Neuropeptide 404 100.00 Very High Very High Very High
Enkephalin 80 100.00 Very High Very High Very High
narcan 45 100.00 Very High Very High Very High
qutenza 15 100.00 Very High Very High Very High
rheumatoid arthritis 465 99.84 Very High Very High Very High
Opioid 33 99.76 Very High Very High Very High
Hippocampus 104 99.68 Very High Very High Very High
Locus ceruleus 26 99.52 Very High Very High Very High
metalloproteinase 1585 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1462 100.00 Very High Very High Very High
Pulmonary Disease 198 100.00 Very High Very High Very High
Heart Failure 186 100.00 Very High Very High Very High
Chronic Renal Failure 165 100.00 Very High Very High Very High
Hypoxia 24 100.00 Very High Very High Very High
Lumbar Puncture Related Headaches 18 100.00 Very High Very High Very High
Cancer 94 99.96 Very High Very High Very High
Endometriosis 1344 99.84 Very High Very High Very High
Rheumatoid Arthritis 465 99.84 Very High Very High Very High
Syndrome 95 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corticotropin-releasing hormone (CRH), a hypothalamic peptide that controls the response of the body to stress and which is also produced by the placenta and intrauterine tissues during pregnancy is potentially involved in the onset of labor.
Gene_expression (produced) of CRH in placenta associated with stress
1) Confidence 0.78 Published 2007 Journal Front. Biosci. Section Abstract Doc Link 17127317 Disease Relevance 0.16 Pain Relevance 0.10
Earlier preterm births are thought more likely to be due to infective or inflammatory etiologies [25] while late preterm births have been suggested to be due to disturbances in the gestational length mechanisms such as increased CRH production from the placenta.
Gene_expression (production) of CRH in placenta associated with inflammation and premature birth
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890413 Disease Relevance 0.78 Pain Relevance 0.10
Epithelial cells of human endometrium express the corticotropin-releasing hormone (CRH) and opioid peptide precursors genes (i.e., proopiomelanocortin, proenkephalin, and prodynorphin) and their end products.
Gene_expression (express) of CRH in endometrium associated with opioid
3) Confidence 0.78 Published 1999 Journal Semin. Reprod. Endocrinol. Section Abstract Doc Link 10406073 Disease Relevance 0.05 Pain Relevance 0.39
Epithelial cells of human endometrium express the corticotropin-releasing hormone (CRH) and opioid peptide precursors genes (i.e., proopiomelanocortin, proenkephalin, and prodynorphin) and their end products.
Gene_expression (express) of corticotropin-releasing hormone in endometrium associated with opioid
4) Confidence 0.78 Published 1999 Journal Semin. Reprod. Endocrinol. Section Abstract Doc Link 10406073 Disease Relevance 0.05 Pain Relevance 0.39
However, as shown in the brain, both CRF receptors and ligands are also widely expressed in the colon and the ileum of humans and rodents, and stress modulates their expression.
Gene_expression (expressed) of CRF in colon associated with stress
5) Confidence 0.78 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20388944 Disease Relevance 0.32 Pain Relevance 0.03
Furthermore, endometrium stroma cells also express CRH when they differentiate into decidual cells.
Gene_expression (express) of CRH in endometrium stroma
6) Confidence 0.78 Published 2002 Journal Hormones (Athens) Section Abstract Doc Link 17018441 Disease Relevance 0.55 Pain Relevance 0.19
Indeed, the epithelial cells of human endometrium express the stress-associated neuropeptide genes corticotropin-releasing hormone (CRH), proopiomelanocortin, proenkephalin and prodynorphin.
Gene_expression (express) of CRH in endometrium associated with stress and neuropeptide
7) Confidence 0.78 Published 2002 Journal Hormones (Athens) Section Abstract Doc Link 17018441 Disease Relevance 0.50 Pain Relevance 0.16
In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid.
Gene_expression (expression) of CRH associated with antidepressant
8) Confidence 0.78 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.19
In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid.
Gene_expression (expression) of corticotropin-releasing hormone associated with antidepressant
9) Confidence 0.78 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.19
Moreover, CRH receptor mRNA and protein expression were examined in the human mast cell line, HMC-1.
Gene_expression (expression) of CRH receptor mRNA in mast cell
10) Confidence 0.78 Published 2008 Journal Gut Section Body Doc Link 17525093 Disease Relevance 0 Pain Relevance 0
Clinically effective therapy with antidepressant drugs normalizes the disturbed activity of HPA axis, in part, by decreasing corticotropin-releasing hormone (CRH) synthesis, but the mechanism of this action is poorly recognized.
Gene_expression (synthesis) of corticotropin-releasing hormone associated with antidepressant
11) Confidence 0.78 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.18 Pain Relevance 0.22
Clinically effective therapy with antidepressant drugs normalizes the disturbed activity of HPA axis, in part, by decreasing corticotropin-releasing hormone (CRH) synthesis, but the mechanism of this action is poorly recognized.
Gene_expression (synthesis) of CRH associated with antidepressant
12) Confidence 0.78 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.18 Pain Relevance 0.22
This failure to find any evidence suggesting an analgesic action of CRH or of the subsequent hormones of the HPA system was obtained despite the fact that CRH produced clear neuroendocrine responses such as increases in the plasma concentration of beta-endorphin and cortisol.
Gene_expression (produced) of CRH in plasma associated with analgesic
13) Confidence 0.77 Published 1999 Journal Pain Section Abstract Doc Link 10506666 Disease Relevance 0.68 Pain Relevance 1.24
Ectopic production of corticotropin-releasing hormone (CRH) by a pheochromocytoma is an infrequent cause of Cushing's syndrome.
Gene_expression (production) of CRH associated with syndrome and pheochromocytoma
14) Confidence 0.77 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17039427 Disease Relevance 0.78 Pain Relevance 0.09
Ectopic production of corticotropin-releasing hormone (CRH) by a pheochromocytoma is an infrequent cause of Cushing's syndrome.
Gene_expression (production) of corticotropin-releasing hormone associated with syndrome and pheochromocytoma
15) Confidence 0.77 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17039427 Disease Relevance 0.77 Pain Relevance 0.09
Sequential stainings or staining comparison of contiguous semi-thin sections failed to prove the coexpression of corticoliberin and [Met]enkephalin immunoreactivities in fibres, but indicated that corticoliberin and vasopressin immunoreactivities may be coexpressed in a few fibres.
Gene_expression (coexpression) of corticoliberin associated with enkephalin
16) Confidence 0.77 Published 1985 Journal Neuroscience Section Abstract Doc Link 3873629 Disease Relevance 0 Pain Relevance 0.19
Sequential stainings or staining comparison of contiguous semi-thin sections failed to prove the coexpression of corticoliberin and [Met]enkephalin immunoreactivities in fibres, but indicated that corticoliberin and vasopressin immunoreactivities may be coexpressed in a few fibres.
Gene_expression (coexpressed) of corticoliberin associated with enkephalin
17) Confidence 0.77 Published 1985 Journal Neuroscience Section Abstract Doc Link 3873629 Disease Relevance 0 Pain Relevance 0.19
Close vicinity of corticoliberin, vasopressin and [Met]enkephalin fibres, in some eminential areas and coexpression of corticoliberin and vasopressin immunoreactivities in some neurons, are morphological correlates of functional relations which were reported.
Gene_expression (coexpression) of corticoliberin in neurons associated with enkephalin
18) Confidence 0.77 Published 1985 Journal Neuroscience Section Abstract Doc Link 3873629 Disease Relevance 0 Pain Relevance 0.22
These nuclei are probably additional sources of CRH in the CSF.
Gene_expression (sources) of CRH
19) Confidence 0.77 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC544567 Disease Relevance 0.25 Pain Relevance 0.29
Corticotropin-releasing hormone (CRH) is produced and acts both within the central nervous system and at several peripheral sites.
Gene_expression (produced) of CRH in central nervous system associated with central nervous system
20) Confidence 0.75 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8739889 Disease Relevance 0 Pain Relevance 0.05

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