INT70821

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Context Info
Confidence 0.25
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ep300) transferase activity, transferring acyl groups (Ep300) DNA binding (Ep300)
transcription factor binding (Ep300) cytoplasm (Ep300)
Ep300 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 98.56 Very High Very High Very High
Neuropathic pain 5 86.12 High High
analgesia 7 67.16 Quite High
antagonist 1 65.48 Quite High
Spinal cord 4 52.80 Quite High
Dorsal horn 6 52.00 Quite High
Glutamate receptor 7 50.00 Quite Low
Analgesic 5 50.00 Quite Low
antinociception 1 39.84 Quite Low
agonist 7 29.36 Quite Low
Disease Link Frequency Relevance Heat
Pain 16 98.56 Very High Very High Very High
Repression 1 93.16 High High
Neuropathic Pain 5 86.12 High High
Cancer 3 85.68 High High
Cognitive Disorder 9 75.96 Quite High
Hypoxia 13 73.00 Quite High
Disease 51 54.60 Quite High
Targeted Disruption 23 52.56 Quite High
Neurodegenerative Disease 2 11.72 Low Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The memory probes elicited an N275 that increased and a P300 that decreased in amplitude during pain.
Positive_regulation (increased) of P300 associated with pain
1) Confidence 0.25 Published 1997 Journal Psychophysiology Section Abstract Doc Link 9260496 Disease Relevance 0.84 Pain Relevance 0.76
C-terminal activation domain from interacting with the transcriptional co-activating protein p300 [16], in turn limiting the transcriptional activity of HIF-1 in a normoxic environment [19].
Positive_regulation (activating) of p300
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.33 Pain Relevance 0
Coactivators such as cAMP response element-binding protein (CBP) and p300 are thought to act as histone acetyltransferases that cause chromatin decondensation to prepare promoters for the recruitment of the RNA polymerase.
Positive_regulation (Coactivators) of p300
3) Confidence 0.15 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.09 Pain Relevance 0
B family, including p50 and p65/Rel-A, and for the coactivator p300.
Positive_regulation (coactivator) of p300
4) Confidence 0.13 Published 2006 Journal Mol Pain Section Body Doc Link PMC1550235 Disease Relevance 0.20 Pain Relevance 0.44

General Comments

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