INT7083

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 20.96
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HBM)
Anatomy Link Frequency
platelet 3
blood 3
brain 2
erythrocyte 1
liver 1
HBM (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 171 99.28 Very High Very High Very High
headache 26 98.64 Very High Very High Very High
imagery 25 98.38 Very High Very High Very High
Opioid 13 94.64 High High
Pain 189 94.28 High High
Potency 3 94.08 High High
tolerance 12 92.40 High High
Endep 6 91.00 High High
Enkephalin 4 90.68 High High
ischemia 8 88.80 High High
Disease Link Frequency Relevance Heat
Stress 64 100.00 Very High Very High Very High
Hypoalbuminemia 1 100.00 Very High Very High Very High
Influenza Virus Infection 54 99.96 Very High Very High Very High
Fatigue 24 99.84 Very High Very High Very High
Cirrhosis 8 99.76 Very High Very High Very High
Jaundice 3 99.74 Very High Very High Very High
Alzheimer's Dementia 3 99.70 Very High Very High Very High
Sleep Disorders 48 99.66 Very High Very High Very High
Insulin Resistance 8 99.56 Very High Very High Very High
Cramps 2 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, a variety of methods have been developed in chemically modifying and stabilizing the hemoglobin molecule.
Positive_regulation (stabilizing) of hemoglobin
1) Confidence 0.66 Published 1999 Journal Crit Care Section Abstract Doc Link PMC137240 Disease Relevance 0.19 Pain Relevance 0.04
In addition, we found that higher levels of perceived seriousness of influenza (HBM2) and greater knowledge about the illness and the vaccine increase the odds of intention to get the vaccine.
Positive_regulation (increase) of HBM2 associated with influenza virus infection
2) Confidence 0.46 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872324 Disease Relevance 0.31 Pain Relevance 0
Hemoglobin levels may be low due to recent viral illnesses or they may be elevated in dehydrated patients [10].
Positive_regulation (elevated) of Hemoglobin
3) Confidence 0.21 Published 2005 Journal BMC Pediatr Section Body Doc Link PMC1322220 Disease Relevance 0.95 Pain Relevance 0
At 6 months, the previously untreated group showed a mean increase in hemoglobin of 0.77 g/dL, platelet count of 41.5 × 109/L or remained stable, and a mean decrease in their chitotriosidase levels of 38.2% (Table 1).
Positive_regulation (increase) of hemoglobin in platelet
4) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504062 Disease Relevance 0.77 Pain Relevance 0.15
Erythrocytosis can develop during testosterone treatment, especially in older men treated by injectable testosterone preparations.45 Hemoglobin at puberty increases 15% to 20% in boys, men have higher levels of hemoglobin than women, and hypogonadism causes a decline in hemoglobin levels that can be restored with testosterone replacement therapy.139,300 But the elevation in hemoglobin above certain levels may have bad outcomes, particularly in elderly, because the increase in blood viscosity could exacerbate vascular disease in the coronary, cerebrovascular, or peripheral vascular circulation, especially in people with other diseases that cause secondary polycythemia, ie, chronic obstructive pulmonary disease.301–303 Injection is associated with higher potentials for erythrocytosis than topical preparations.240 Snyder et al noticed that erythrocytosis occurred in 5.5% of scrotal transdermal users, and the majority of changes took place over the first three months of treatment.92 It has been demonstrated that testosterone dosage correlates with the incidence of erythrocytosis,67 The frequency of polycythemia (hematocrit over 51%) is related most of the time to supra-physiological levels.240 The resolution of erythrocytosis (hematocrit >52%), untreated obstructive sleep apnea, or untreated severe congestive heart failure, is required before starting on testosterone treatment.19,58,304
Positive_regulation (elevation) of hemoglobin in blood associated with apnoea, transdermal, pulmonary disease, hypogonadotropic hypogonadism, erythrocytosis, frailty, disease and increased venous pressure under development
5) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 1.81 Pain Relevance 0.07
All patients responded with significantly increased hemoglobin concentrations.
Positive_regulation (increased) of hemoglobin
6) Confidence 0.07 Published 1992 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 1337953 Disease Relevance 0 Pain Relevance 0.21
The dotted lines represent the first and third quadrant bisectors: when the VMR pattern is in the region comprised between the two bisectors, it means that the oxygenated hemoglobin concentration is increasing and, more specifically, it is increasing more than the reduced hemoglobin concentration.
Positive_regulation (increasing) of hemoglobin
7) Confidence 0.05 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.07 Pain Relevance 0
He was subsequently started on lenalidomide and responded initially with the hemoglobin level increasing to 11-12 gram range and platelet counts increasing to 130,000 - 150,000 range.
Positive_regulation (increasing) of hemoglobin in platelet
8) Confidence 0.05 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2873355 Disease Relevance 0.36 Pain Relevance 0
fMRI is a noninvasive brain imaging technique that relies on changes in the relative concentration of oxygenated to deoxygenated hemoglobin within the brain.
Positive_regulation (deoxygenated) of hemoglobin in brain associated with imagery
9) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643113 Disease Relevance 0.60 Pain Relevance 0.80
The same fragments occur in human hemoglobin in positions 32-41 and 33-41 of the beta-chain, respectively.
Positive_regulation (occur) of hemoglobin
10) Confidence 0.05 Published 1992 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1449465 Disease Relevance 0 Pain Relevance 0.38
Functional MRI could show the signal change while the hemoglobin status is changing.
Positive_regulation (changing) of hemoglobin
11) Confidence 0.04 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952336 Disease Relevance 0.32 Pain Relevance 0.53
They were monitored during this period and the results show that the study product was effective in increasing their hemoglobin and hematocrit values significantly.
Positive_regulation (increasing) of hemoglobin
12) Confidence 0.04 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0.21 Pain Relevance 0
Further treatment with formulation A induced significant increases in hemoglobin and hematocrit (Table 6).
Positive_regulation (increases) of hemoglobin
13) Confidence 0.04 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0.63 Pain Relevance 0.23
To quantify VMR from the NIRS data, we estimated the chromophores concentration changes with respect to the BH duration [7]:

As in equation 2, O2HbBASE is the oxygenated hemoglobin concentration in baseline conditions, averaged on the same 10s time window during which the VBASE is evaluated, and O2HbBH is the average concentration after the release of the BH.

Positive_regulation (oxygenated) of hemoglobin
14) Confidence 0.04 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.16 Pain Relevance 0
2. the VMR phase, in which there is a strong increase of the O2Hb (and, hence, of the total hemoglobin, that roughly corresponds to the regional cerebral blood volume) while the CO2Hb is kept at a baseline level;
Positive_regulation (increase) of hemoglobin in blood
15) Confidence 0.04 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.17 Pain Relevance 0.03
All laboratory tests were unchanged from baseline to week 8 for all groups with the following exceptions.

(1) Group A hemoglobin was increased from 12.0 ± 0.2 to 12.5 ± 0.3, p < 0.05 (2) Group B lymphocyte levels increased from 30.3 ± 1.8 to 34.3 ± 1.8, p < 0.05

Positive_regulation (increased) of hemoglobin in B lymphocyte
16) Confidence 0.04 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.07 Pain Relevance 0.30
Moreover, vasoreactivity is triggered by a CO2increase, but the quantification of VMR itself is usually done by taking into account the increases in both oxygenated and reduced hemoglobin; this because VMR is a functional physiological process aiming at maintaining a proper chromophores concentration in brain tissues.
Positive_regulation (increases) of hemoglobin in brain
17) Confidence 0.04 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.32 Pain Relevance 0
Deoxygenation increases hemoglobin auto-oxidation and generation of reactive oxygen species at the inside of the red cell membrane [53], a process exacerbated in sickle red cells.
Positive_regulation (increases) of hemoglobin
18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.16 Pain Relevance 0
Stable increments in hemoglobin and hematocrit are only reached after prolonged treatment, as was found in these patients.
Positive_regulation (increments) of hemoglobin
19) Confidence 0.03 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0 Pain Relevance 0
Additionally, further treatment of the patients with the study product yielded satisfactory increases in hemoglobin and hematocrit values.


Positive_regulation (increases) of hemoglobin
20) Confidence 0.03 Published 2005 Journal BMC Nephrol Section Abstract Doc Link PMC1164417 Disease Relevance 0.34 Pain Relevance 0.09

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