INT70837

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.63
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
gray matter 2
CRYGS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 37 99.98 Very High Very High Very High
Sumatriptan 4 99.92 Very High Very High Very High
opioid receptor 3 99.56 Very High Very High Very High
gABA 11 98.88 Very High Very High Very High
fortral 3 98.64 Very High Very High Very High
Opioid 20 98.04 Very High Very High Very High
antagonist 9 95.52 Very High Very High Very High
Clonidine 2 95.16 Very High Very High Very High
Potency 6 93.32 High High
GABA receptor 1 89.32 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 2 94.60 High High
Bordatella Infection 4 76.04 Quite High
Glioma 3 75.00 Quite High
Vibrio Infection 1 58.32 Quite High
Increased Venous Pressure Under Development 1 31.12 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Coronary Artery Disease 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cortical sections, [35S]GTPgammaS binding to gray matter was stimulated by the agonist UK14304.
Positive_regulation (stimulated) of GTPgammaS Binding (binding) of in gray matter associated with agonist
1) Confidence 0.45 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.38
In conditions of 50 microM GDP and 100 mM NaCl, UK14304 increased the apparent affinity of the specific [35S]GTPgammaS binding without changing the apparent density.
Positive_regulation (increased) of GTPgammaS Binding (binding) of
2) Confidence 0.39 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10708703 Disease Relevance 0 Pain Relevance 0.33
The stimulation of [35S]GTPgammaS binding by the mu-opioid receptor agonist DAMGO or the alpha2-adrenoceptor agonist UK14304 was used as a functional measure of the status of the receptor-G-protein coupling. [35S]GTPgammaS binding basal values were similar in opioid addicts (819+/-83 fmol mg-1 of protein) and controls (918+/-106 fmol mg(-1) of protein).
Positive_regulation (stimulation) of GTPgammaS Binding (binding) of associated with agonist, opioid receptor and opioid
3) Confidence 0.09 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889534 Disease Relevance 0.09 Pain Relevance 0.94
The rank order of potencies of adrenergic ligands tested in stimulating [3S]GTPgammaS binding and inhibiting forskolin-stimulated c-AMP accumulation was UK 14304> Guanabenz acetate> Oxymetazoline hydrochloride> B-HT 920 dihydrochloride> p-Aminoclonidine hydrochloride> Clonidine hydrochloride.
Positive_regulation (accumulation) of GTPgammaS Binding (binding) of associated with clonidine
4) Confidence 0.06 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.21
The presence of 100 mM Na+ was necessary to produce the maximal signal-to-background ratio. (-)U50,488H-induced increase in [35S]GTPgammaS binding was time- and tissue concentration-dependent. (-)U50,488H increased [35S]GTPgammaS binding in a dose-dependent manner with an EC50 of 3.1 nM. (+)-U50,488H had no effect, which indicates that this effect is stereospecific.
Positive_regulation (increase) of GTPgammaS Binding (binding) of
5) Confidence 0.06 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.19 Pain Relevance 0.24
Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline (UK 14304), increased the binding of [35S]GTPgammaS up to approximately 1.8 fold, with half-maximal increase at 60 nM and was competitively inhibited by the alpha2-AR antagonist Rauwolscine.
Positive_regulation (increased) of GTPgammaS Binding (binding) of associated with antagonist and agonist
6) Confidence 0.06 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.13
In addition, (-)tifluadom, the less potent isomer of tifluadom, which is also a gamma-aminobutyric acidA receptor agonist, stimulated [35S]GTPgammaS binding.
Positive_regulation (stimulated) of GTPgammaS Binding (binding) of associated with agonist
7) Confidence 0.06 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918595 Disease Relevance 0.20 Pain Relevance 0.55
The efficacy of L-694,247, 5-CT, 5-HT and sumatriptan in stimulating [35S]GTPgammaS binding (a measure of G protein coupling) to membranes of cells expressing the VR was approximately 50-65% lower compared to membranes of cells expressing the WTR, but their potency was 2.8-3.6-fold higher.
Positive_regulation (stimulating) of GTPgammaS Binding (binding) of associated with sumatriptan and potency
8) Confidence 0.02 Published 2000 Journal Pharmacogenetics Section Abstract Doc Link 11037806 Disease Relevance 0.07 Pain Relevance 0.48
This is a functional assay because GTPgamma35S will be bound to cell membranes only when activation of metabotropic receptors has lead to binding and activation of their associated G(alpha)-proteins via release of GDP and binding of the GTPgamma35S.
Positive_regulation (activation) of GTPgamma35S Binding (binding) of
9) Confidence 0.02 Published 2001 Journal J Endod Section Abstract Doc Link 11592491 Disease Relevance 0 Pain Relevance 0.76
Thus, when corrected for expression levels of the receptor, low-density domains exhibited four times higher agonist-stimulated GTPase and [35S]GTPgammaS binding than the bulk plasma membranes.
Positive_regulation (stimulated) of GTPgammaS Binding (binding) of in plasma associated with agonist
10) Confidence 0.02 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12641725 Disease Relevance 0.07 Pain Relevance 0.61

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