INT70840

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Context Info
Confidence 0.09
First Reported 1997
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
ciliary bodies 2
CHO 2
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 99.84 Very High Very High Very High
Kinase C 6 99.34 Very High Very High Very High
Kappa opioid receptor 4 96.72 Very High Very High Very High
antagonist 3 62.24 Quite High
narcan 2 48.16 Quite Low
nalbuphine 2 25.00 Low Low
Buprenorphine 2 25.00 Low Low
Dynorphin 2 25.00 Low Low
fortral 2 25.00 Low Low
Opioid 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 2 93.64 High High
Vibrio Infection 1 25.00 Low Low
Ocular Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the effects of activation of the human kappa receptor by agonists on [35S]GTPgammaS binding to CHO cell membranes were examined.
Spec (examined) Regulation (effects) of Spec (examined) Positive_regulation (activation) of kappa receptor in CHO associated with agonist
1) Confidence 0.09 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262330 Disease Relevance 0.09 Pain Relevance 0.22
The present study was designed to examine the roles of protein kinase C (PKC) and phosphodiesterase (PDE) in modulating the action of kappa receptor stimulation on cAMP accumulation in isolated iris-ciliary bodies (ICBs) of New Zealand White rabbits.
Regulation (modulating) of Positive_regulation (stimulation) of kappa receptor in ciliary bodies associated with kinase c
2) Confidence 0.03 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11961062 Disease Relevance 0 Pain Relevance 0.28

General Comments

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