INT70848

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 10.97
Pain Relevance 8.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
skin 5
spleen 4
pancreas 2
spinal cord 1
PVN 1
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hyperalgesia 7 100.00 Very High Very High Very High
metalloproteinase 6 100.00 Very High Very High Very High
Thermal hyperalgesia 4 100.00 Very High Very High Very High
Spinal cord 6 99.68 Very High Very High Very High
Morphine 20 99.32 Very High Very High Very High
Neuritis 5 99.08 Very High Very High Very High
Chronic pancreatitis 12 98.60 Very High Very High Very High
gABA 5 98.36 Very High Very High Very High
intrathecal 3 97.92 Very High Very High Very High
allodynia 15 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 12 100.00 Very High Very High Very High
Adenocarcinoma 6 99.84 Very High Very High Very High
Osteoarthritis 3 99.76 Very High Very High Very High
Sprains And Strains 11 99.70 Very High Very High Very High
Stress 3 99.26 Very High Very High Very High
Pancreatitis 12 99.20 Very High Very High Very High
Experimental Autoimmune Neuritis 5 99.08 Very High Very High Very High
Adenoma 6 98.04 Very High Very High Very High
Neuropathic Pain 15 97.24 Very High Very High Very High
Nociception 28 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that chronic use of morphine, but not ethanol, attenuates the expression of ICE in the spleen.
Gene_expression (expression) of ICE in spleen associated with morphine
1) Confidence 0.77 Published 1997 Journal Immunol. Lett. Section Abstract Doc Link 9293396 Disease Relevance 0 Pain Relevance 0.43
The expression of ICE in the spleen of rats given chronic morphine was clearly less than that of the animals given placebo, however, it was similar for both rats on ethanol and control diets.
Gene_expression (expression) of ICE in spleen associated with morphine
2) Confidence 0.77 Published 1997 Journal Immunol. Lett. Section Abstract Doc Link 9293396 Disease Relevance 0 Pain Relevance 0.44
In this study, we examined the expression of ICE in the spleens of rats given chronic treatment with morphine versus ethanol using reverse transcriptase-polymerase chain reaction (RT-PCR).
Spec (examined) Gene_expression (expression) of ICE in spleens associated with morphine
3) Confidence 0.77 Published 1997 Journal Immunol. Lett. Section Abstract Doc Link 9293396 Disease Relevance 0 Pain Relevance 0.42
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.
Gene_expression (Overexpression) of Caspase-1 in pancreas associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.76 Published 2003 Journal World J. Gastroenterol. Section Title Doc Link 14669344 Disease Relevance 0.20 Pain Relevance 0.19
In chronic pancreatitis, overexpression of Caspase-1 was found in atrophic acinar cells (89%), hyperplastic ducts (87%), and dedifferentiating acinar cells (84%).
Gene_expression (overexpression) of Caspase-1 in ducts
5) Confidence 0.76 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669344 Disease Relevance 0.15 Pain Relevance 0
Pancreatic cancer tissues showed a clear cytoplasmatic overexpression of Caspase-1 in tumor cells of 71% of the tumors, whereas normal pancreatic tissues showed only occasional immunoreactivity.
Spec (clear) Gene_expression (overexpression) of Caspase-1
6) Confidence 0.76 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669344 Disease Relevance 0.16 Pain Relevance 0
AIM: To identify the expression of Caspase-1(interleukin-1beta converting enzyme) and its role in adenoma of the pancreas and chronic pancreatitis.
Gene_expression (expression) of Caspase-1 in pancreas associated with adenoma and chronic pancreatitis
7) Confidence 0.76 Published 2003 Journal World J. Gastroenterol. Section Abstract Doc Link 14669344 Disease Relevance 0.34 Pain Relevance 0.17
Western blot analysis revealed a marked expression of the 45 kDa precursor of Caspase-1 in pancreatic cancer and chronic pancreatitis (80% and 86%, respectively).
Gene_expression (expression) of Caspase-1
8) Confidence 0.76 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669344 Disease Relevance 0.12 Pain Relevance 0
METHODS: The expression of Caspase-1 was assessed in 42 pancreatic cancer tissue samples, 38 chronic pancreatitis specimens, and 9 normal pancreatic tissues by immunohistochemistry and Western blot analysis.
Gene_expression (expression) of Caspase-1
9) Confidence 0.76 Published 2003 Journal World J. Gastroenterol. Section Body Doc Link 14669344 Disease Relevance 0.20 Pain Relevance 0
IL-1 beta converting enzyme (ICE), a proteolytic enzyme that converts the inactive precursor of interleukin-1 beta (IL-1 beta) to its mature active form, has been abundantly detected in the IL-1 beta producing cells in the spleen.
Gene_expression (detected) of ICE in spleen
10) Confidence 0.66 Published 1997 Journal Immunol. Lett. Section Abstract Doc Link 9293396 Disease Relevance 0 Pain Relevance 0.29
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (present) of caspase-1 in skin associated with allodynia, antagonist and cytokine
11) Confidence 0.65 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.87 Pain Relevance 0.73
It is known that inflammasome multi-protein complexes containing caspase-1 and NALP1 are involved in the activation of the IL-1beta family of pro-nociceptive cytokines expressed in skin and other tissues.
Gene_expression (containing) of caspase-1 in skin associated with nociception and cytokine
12) Confidence 0.57 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.78 Pain Relevance 0.47
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (components) of caspase-1 in skin associated with allodynia, antagonist and cytokine
13) Confidence 0.57 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.88 Pain Relevance 0.73
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (products) of caspase-1 in skin associated with allodynia, antagonist and cytokine
14) Confidence 0.57 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.88 Pain Relevance 0.73
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (co-expressed) of caspase-1 in skin associated with allodynia, antagonist and cytokine
15) Confidence 0.51 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.84 Pain Relevance 0.73
In our present study we analyzed the expression of IL-18 and caspase-1 in the nerve roots of EAN rats using reverse transcriptase-polymerase chain reaction and immunocytochemistry.
Spec (analyzed) Gene_expression (expression) of caspase-1 in nerve associated with neuritis
16) Confidence 0.35 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.19 Pain Relevance 0.62
In contrast, no significant difference was observed for caspase 1 expression between genders.
Gene_expression (expression) of caspase 1
17) Confidence 0.35 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17166174 Disease Relevance 0.92 Pain Relevance 0.08
Together, these data suggest that PGE2, synthesised in response to IL-1beta-activation of COX-2 expressing cells, directly hyperpolarises putative GABA-ergic neurones in the halo zone surrounding and projecting to the PVN, resulting in a decrease in GABA-ergic input to parvocellular neurones and consequent depolarisation.
Gene_expression (expressing) of IL-1beta-activation in PVN associated with gaba
18) Confidence 0.33 Published 2005 Journal J. Neuroendocrinol. Section Abstract Doc Link 16011486 Disease Relevance 0 Pain Relevance 0.48
Six hours later, local oedema, thermal and mechanical hyperalgesia as well as cerebrospinal fluid prostaglandin E2 concentration and tumour necrosis factor-alpha and interleukin 1beta-stimulated production in whole blood cultures were measured.
Gene_expression (production) of interleukin 1beta-stimulated in blood
19) Confidence 0.32 Published 2010 Journal Eur J Anaesthesiol Section Body Doc Link 20540174 Disease Relevance 0.16 Pain Relevance 0
Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1beta-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord.
Gene_expression (expression) of interleukin-1beta-induced in spinal cord associated with thermal hyperalgesia and spinal cord
20) Confidence 0.13 Published 2005 Journal J. Neurochem. Section Title Doc Link 16033422 Disease Relevance 0.35 Pain Relevance 0.61

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