INT70850

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 18.95
Pain Relevance 9.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
myocardium 4
plasma 4
liver 4
medulla 2
endothelial cells 2
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 25 100.00 Very High Very High Very High
cytokine 23 99.98 Very High Very High Very High
medulla 4 99.12 Very High Very High Very High
ischemia 39 98.32 Very High Very High Very High
agonist 50 97.80 Very High Very High Very High
Inflammation 111 97.44 Very High Very High Very High
Spinal cord 12 96.88 Very High Very High Very High
c fibre 1 95.32 Very High Very High Very High
Eae 4 95.04 Very High Very High Very High
COX-2 inhibitor 3 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 25 100.00 Very High Very High Very High
Functional Bowel Disorder 5 100.00 Very High Very High Very High
Injury 77 99.32 Very High Very High Very High
Urological Neuroanatomy 5 99.24 Very High Very High Very High
Colitis 5 99.22 Very High Very High Very High
Heart Rate Under Development 1 98.76 Very High Very High Very High
Cv Unclassified Under Development 32 98.32 Very High Very High Very High
Glioma 3 98.20 Very High Very High Very High
Pressure Volume 2 Under Development 2 98.12 Very High Very High Very High
Sepsis 6 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the administration of BW attenuated the increase in iNOS mRNA expression and NO production in AA rats receiving indomethacin.
Positive_regulation (increase) of Transcription (expression) of iNOS associated with arthritis
1) Confidence 0.70 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19122291 Disease Relevance 0.91 Pain Relevance 0.44
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Positive_regulation (increased) of Transcription (transcription) of iNOS
2) Confidence 0.69 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.57 Pain Relevance 0.24
B can induce the expression of iNOS mRNA through NF-?
Positive_regulation (induce) of Transcription (expression) of iNOS
3) Confidence 0.65 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952320 Disease Relevance 1.12 Pain Relevance 0
In this study, we examined the time course of inducible NO synthase (iNOS) mRNA expression and the plasma TNF-alpha and IL-1beta in lipopolysaccharide (LPS)-treated conscious rats.
Spec (examined) Positive_regulation (inducible) of Transcription (expression) of iNOS in plasma
4) Confidence 0.50 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.37 Pain Relevance 0.12
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Positive_regulation (increased) of Transcription (activity) of iNOS
5) Confidence 0.50 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.57 Pain Relevance 0.24
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Positive_regulation (levels) of Transcription (activity) of inducible NO synthase
6) Confidence 0.50 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.57 Pain Relevance 0.24
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Positive_regulation (increased) of Transcription (activity) of inducible NO synthase
7) Confidence 0.50 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.57 Pain Relevance 0.24
Elevated NO synthesis occurred in parallel with increased inducible NO synthase (iNOS) enzyme activity and mass, steady-state levels of iNOS mRNA, increased transcription of the iNOS gene, and increased iNOS promoter activity.
Positive_regulation (levels) of Transcription (activity) of iNOS
8) Confidence 0.50 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9262377 Disease Relevance 0.57 Pain Relevance 0.24
The initial study using rats showed that heroin administration (0, 0.01, 0.1, or 1.0 mg/kg s.c.) results in a pronounced reduction in lipopolysaccharide (LPS)-induced expression of iNOS mRNA in spleen, lung, and liver tissue as measured by RT-PCR.
Positive_regulation (induced) of Transcription (expression) of iNOS in liver
9) Confidence 0.47 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10741899 Disease Relevance 0.17 Pain Relevance 0.14
The expression of the mRNA for inducible nitric oxide synthase (iNOS) mRNA expression and the production of nitric oxide (NO) in the gastric mucosa of AA rats were also increased by the administration of indomethacin.
Positive_regulation (increased) of Transcription (expression) of iNOS associated with arthritis
10) Confidence 0.47 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19122291 Disease Relevance 1.13 Pain Relevance 0.71
The local increase in iNOS mRNA expression paralleled both the temporal and spatial protein expression.
Positive_regulation (increase) of Transcription (expression) of iNOS
11) Confidence 0.47 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10076904 Disease Relevance 1.02 Pain Relevance 0.69
We found that (1) expression of iNOS and eNOS mRNA in endothelial cells was increased by chronic exercise and (2) chronic exercise blunted phenylephrine-induced vascular responses, probably by increasing NO release via iNOS.
Positive_regulation (increased) of Transcription (expression) of iNOS in endothelial cells
12) Confidence 0.46 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.09
1) on iNOS mRNA expression in LPS-stimulated RAW 264.7 cells.
Positive_regulation (stimulated) of Transcription (expression) of iNOS in RAW 264
13) Confidence 0.46 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892354 Disease Relevance 0 Pain Relevance 0
In this study, we examined the time course of inducible NO synthase (iNOS) mRNA expression and the plasma TNF-alpha and IL-1beta in lipopolysaccharide (LPS)-treated conscious rats.
Spec (examined) Positive_regulation (inducible) of Transcription (expression) of inducible NO synthase in plasma
14) Confidence 0.44 Published 2006 Journal Life Sci. Section Abstract Doc Link 16181643 Disease Relevance 0.37 Pain Relevance 0.12
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increase) of Transcription (levels) of iNOS associated with necrosis, cancer and apoptosis
15) Confidence 0.43 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.78 Pain Relevance 0.78
SC-560, but not rofecoxib, caused intestinal hypermotility, bacterial invasion, and COX-2 as well as iNOS mRNA expression, yet the iNOS and MPO activity was increased only when rofecoxib was also administered.
Positive_regulation (caused) of Transcription (expression) of iNOS associated with functional bowel disorder and urological neuroanatomy
16) Confidence 0.42 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438549 Disease Relevance 0.58 Pain Relevance 0.30
Moreover, a significant increase in the expression of mRNA for IL-1beta, GDNF and iNOS were observed 6h following the HFS conditioning (p<0.05, HFS vs. control).
Positive_regulation (increase) of Transcription (expression) of iNOS
17) Confidence 0.40 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.25 Pain Relevance 0.82
The expression of inducible nitric oxide synthase (iNOS) mRNA in rat myocardium was detected by RT-PCR and the expression of iNOS protein was detected by Western blot.
Positive_regulation (inducible) of Transcription (expression) of inducible nitric oxide synthase in myocardium
18) Confidence 0.39 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.66 Pain Relevance 0.15
The expression of inducible nitric oxide synthase (iNOS) mRNA in rat myocardium was detected by RT-PCR and the expression of iNOS protein was detected by Western blot.
Positive_regulation (inducible) of Transcription (expression) of iNOS in myocardium
19) Confidence 0.39 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 18418440 Disease Relevance 0.66 Pain Relevance 0.15
QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increase) of Transcription (levels) of inducible nitric oxide synthase associated with necrosis, cancer and apoptosis
20) Confidence 0.38 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11170729 Disease Relevance 1.77 Pain Relevance 0.78

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