INT70860

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 7.00
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SNRPB) nucleoplasm (SNRPB) mRNA processing (SNRPB)
nucleus (SNRPB) cytoplasm (SNRPB)
Anatomy Link Frequency
lung 2
lateral 1
skin 1
heart 1
SNRPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 5 100.00 Very High Very High Very High
psoriasis 7 99.68 Very High Very High Very High
cocaine 11 99.64 Very High Very High Very High
Morphine 4 99.64 Very High Very High Very High
Bile 2 87.36 High High
Nicotine 7 86.76 High High
Inflammation 88 67.52 Quite High
Angina 9 57.20 Quite High
imagery 3 49.68 Quite Low
cytokine 31 19.28 Low Low
Disease Link Frequency Relevance Heat
Peritoneal Panniculitis 35 100.00 Very High Very High Very High
Lung Injury 21 100.00 Very High Very High Very High
Coronary Artery Disease 48 99.80 Very High Very High Very High
Death 112 99.76 Very High Very High Very High
Malignant Neoplastic Disease 6 99.76 Very High Very High Very High
Psoriasis 7 99.68 Very High Very High Very High
Skin Diseases 7 99.20 Very High Very High Very High
Lymphatic System Cancer 4 99.00 Very High Very High Very High
Myocardial Infarction 15 98.24 Very High Very High Very High
Colon Cancer 3 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exons 4–10 encode SmN, a homolog of the SmB/B' protein that binds small nuclear RNAs involved in pre-mRNA splicing.
SmB/B' Binding (binds) of
1) Confidence 0.35 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.27 Pain Relevance 0
For COC, the addition of COD, MEPH, and CE enhanced serum binding whereas MORP and BE decreased it.
COD Binding (binding) of associated with morphine, codeine and cocaine
2) Confidence 0.23 Published 1997 Journal Ther Drug Monit Section Abstract Doc Link 9263384 Disease Relevance 0 Pain Relevance 1.18
The association of SM with outcome was evaluated by Cox regression analyses adjusted for potential confounders.
SM Binding (association) of
3) Confidence 0.20 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.37 Pain Relevance 0
We aimed to assess any evidence of association between SM and CAD in models, assuming both linear and nonlinear effects.
SM Binding (association) of associated with coronary artery disease
4) Confidence 0.15 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.30 Pain Relevance 0
We investigated in a median follow up of 6.0 years the association of SM with the incidence of a combined endpoint (myocardial infarction and cardiovascular death) in stable and unstable patients, and its relation to other marker of atherosclerosis in 1,102 patients with angiographically documented CAD and 444 healthy controls.


SM Binding (association) of associated with coronary artery disease, atherosclerosis, death and myocardial infarction
5) Confidence 0.15 Published 2006 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC1360085 Disease Relevance 0.69 Pain Relevance 0.06
, about the same sensorimotor context SM (?
SM Binding (about) of
6) Confidence 0.10 Published 2007 Journal Frontiers in Neurorobotics Section Body Doc Link PMC2533589 Disease Relevance 0 Pain Relevance 0
This can be implemented as:

(20)r(SM(?

SM Binding (implemented) of
7) Confidence 0.10 Published 2007 Journal Frontiers in Neurorobotics Section Body Doc Link PMC2533589 Disease Relevance 0 Pain Relevance 0
with SM (t) belonging to region Rn and where ?
SM Binding (belonging) of
8) Confidence 0.10 Published 2007 Journal Frontiers in Neurorobotics Section Body Doc Link PMC2533589 Disease Relevance 0 Pain Relevance 0
Preliminary experiments showed that 2F8 conjugates bind specifically to SM-treated ssDNA and run well in the lateral flow technology system.
SM Binding (bind) of in lateral
9) Confidence 0.03 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0 Pain Relevance 0
The research group of Goodman worked on the cytostatic and cytotoxic properties of SM and its nitrogen relatives during World War II.3 This research was declassified after World War II and resulted in medical applications of alkylating mustard compounds, for example, the first successful therapy of leukemia.3 The cytostatic effect of SM was also used to treat hyperproliferative skin diseases, for example, psoriasis.4 In addition, recognition of SM as an immunosuppressant compound prompted studies about chemical immunosuppression.
SM Binding (recognition) of in skin associated with psoriasis, leukemia and skin diseases
10) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.51 Pain Relevance 0.05
In an aqueous environment, SM quickly reacts with DNA and forms in 61% alkylations to N7 of guanine forming 7-(2-hydroxyethylthioethyl) guanine (7-HETE-G).50–52 In our immunochromatographic detection system, a well-characterized antibody (2F8) was used, which demonstrated high specificity and sensitivity for SM ssDNA adducts in ELISA assays.14 In the first project phase the antibody was purified and conjugated to colloidal gold particles that are used for visualization of the test line.
SM Binding (reacts) of
11) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0 Pain Relevance 0
Thus, high SM concentrations can rapidly deplete the intracellular glutathione levels, resulting in the enhanced production of reactive oxygen species.44 Consequently, pretreatment of cells with various antioxidants does not only enhance cell survival44,45 but antioxidants have also been shown to be most effective in treating SM lung injury in animal models.46–48
SM Binding (injury) of in lung associated with lung injury
12) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.10 Pain Relevance 0
Pseudomembranes may loosen from the bronchiotracheal wall and cause obstruction of the airways or even provoke heart arrest (thus, leading to fatal outcome).27 As early as 1921, Koch described 1 case that showed a collapsed right lung as consequence of pseudomembranous obstruction of the right main stem bronchus.28 He reviewed the pathological findings in 62 cases of lethal gassing with SM.
SM Binding (gassing) of in heart associated with heart rate under development
13) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 1.01 Pain Relevance 0
At high SM concentrations, PARP-1 is excessively activated resulting in rapid NAD+ and ATP depletion,67,68 which is associated with necrotic cell death.69–72
SM Binding (concentrations) of associated with death
14) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.91 Pain Relevance 0.04
A reliable diagnostic tool to monitor and confirm the presence of SM even after decontamination procedures is still being needed.
SM Binding (presence) of
15) Confidence 0.02 Published 2008 Journal Eplasty Section Body Doc Link PMC2431646 Disease Relevance 0.05 Pain Relevance 0
Both dietary and membrane SM interact strongly with cholesterol [5].
SM Binding (interact) of
16) Confidence 0.02 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.28 Pain Relevance 0
In rodents digestion of SM is extended and has a limited capacity and the physical interaction between SM and cholesterol may be important.
SM Binding (interaction) of
17) Confidence 0.01 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0 Pain Relevance 0.04
An association of SM with malignancy, namely lymphoma, breast-, lung- and colon cancer, as well as melanoma has been reported, which could further complicate the diagnosis [1,12,14].
SM Binding (association) of in lung associated with malignant neoplastic disease, lymphatic system cancer, colon cancer, peritoneal panniculitis and skin cancer
18) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615039 Disease Relevance 2.50 Pain Relevance 0.09

General Comments

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