INT70884

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.22
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
neck 1
lung 1
hearts 1
Pdgfb (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
Angina 1 96.04 Very High Very High Very High
chemokine 16 67.68 Quite High
Inflammation 18 63.88 Quite High
ischemia 49 63.28 Quite High
Opioid 23 59.60 Quite High
MU agonist 4 58.20 Quite High
antagonist 15 55.88 Quite High
fibrosis 38 50.00 Quite Low
Antiemetics 1 36.84 Quite Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 5 98.70 Very High Very High Very High
Coronary Heart Disease 5 98.56 Very High Very High Very High
Cv Unclassified Under Development 51 97.56 Very High Very High Very High
Cv General 3 Under Development 1 96.04 Very High Very High Very High
Pressure And Volume Under Development 24 95.92 Very High Very High Very High
Cancer 216 95.52 Very High Very High Very High
Respiratory Syncytial Virus 102 94.24 High High
Targeted Disruption 36 92.24 High High
Apoptosis 22 89.12 High High
Death 5 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice with homozygous deletions of PDGF-B or PDGFR-?
Localization (deletions) of PDGF-B
1) Confidence 0.35 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 2.19 Pain Relevance 0
To investigate involvement of growth factors on myocardial hypertrophy in HCM patients, we evaluated gene expression and cellular localization of transforming growth factor-beta1 (TGF-beta1), insulin-like growth factors (IGF-I and IGF-II), and platelet-derived growth factor-B (PDGF-B) in ventricular biopsies obtained from patients with HCM (n=8), aortic stenosis (AS) (n=8), or stable angina (SA) (n=8) and from explanted hearts with ischemic cardiomyopathy (TM) (n=7).
Localization (localization) of platelet-derived growth factor-B in hearts associated with angina, hypertrophic cardiomyopathy, cv unclassified under development and coronary heart disease
2) Confidence 0.15 Published 1997 Journal Circulation Section Abstract Doc Link 9264495 Disease Relevance 0.94 Pain Relevance 0.10
1, CTGF, and PDGF-C) were significantly increased by V2O5 exposure in whole lung tissue at 21 days post-exposure (Fig. 6).
Localization (increased) of PDGF in lung
3) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.90 Pain Relevance 0.09
This is in agreement with our previous publication demonstrating potent secretion of angiogenic cytokines such as PDGF-BB and angiopoietin [52].
Localization (secretion) of PDGF associated with cytokine
4) Confidence 0.10 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.18 Pain Relevance 0.08
FISH demonstrated the COL1A1-PDGF-B translocation.
Localization (translocation) of PDGF-B
5) Confidence 0.08 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.54 Pain Relevance 0
l)) and PDGF receptor (C-20 epitope; rabbit polyclonal IgG (5 ?
Localization (receptor) of PDGF
6) Confidence 0.08 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.15
Rac1 flox/flox and Rac1 flox/flox PDGFB-iCreER mice were implanted subcutaneously with tamoxifen (Rac1 flox/flox and Rac1 flox/flox PDGFB-iCreER) or placebo (Rac1 flox/flox PDGFB-iCreER) 1 mg-slow release pellets in the scruff of the neck.
Localization (release) of PDGFB-iCreER in neck
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0
The serum and various growth factors such as PDGF, FGF, EGF, and TGF-?
Neg (no) Localization (serum) of PDGF
8) Confidence 0.01 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 1.21 Pain Relevance 0

General Comments

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