INT70885

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1997
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 48
Total Number 53
Disease Relevance 42.27
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
pericyte 6
brain 3
platelet 3
fat 2
vasculature 2
Pdgfb (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 160 99.84 Very High Very High Very High
metalloproteinase 17 98.68 Very High Very High Very High
cva 33 98.56 Very High Very High Very High
fibrosis 72 98.48 Very High Very High Very High
Angina 5 96.04 Very High Very High Very High
Dopamine 48 92.72 High High
Inflammation 178 92.60 High High
isoflurane 52 91.04 High High
Opioid 23 91.04 High High
dexamethasone 1 87.76 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 395 100.00 Very High Very High Very High
Cancer 3067 99.96 Very High Very High Very High
Experimental Melanoma 175 99.84 Very High Very High Very High
Glioma 202 99.80 Very High Very High Very High
Disease 268 99.72 Very High Very High Very High
Brain Tumor 244 99.64 Very High Very High Very High
Diabetes Mellitus 81 99.52 Very High Very High Very High
Solid Tumor 56 99.28 Very High Very High Very High
Hypertrophic Cardiomyopathy 5 99.18 Very High Very High Very High
Coronary Heart Disease 5 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B16 melanoma cells (1 × 106 mock-transfected or PDGF-BB expressing cells) were injected subcutaneously in 100 ?
Gene_expression (expressing) of PDGF-BB associated with experimental melanoma
1) Confidence 0.67 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.17 Pain Relevance 0.05
Instead, in comparison to the wild type B16 tumors grown in wild type mice, those grown in D849N-mutant mice generally displayed increased pericyte numbers per vessel perimeter, independent of tumoral PDGF-BB expression (p < 0.05) (Fig. 1D).
Gene_expression (expression) of PDGF-BB in pericyte associated with cancer
2) Confidence 0.67 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.05 Pain Relevance 0
Furthermore, the average vessel surface of PDGF-BB-expressing tumors was slightly higher in D849N-mutant mice (2362 +/- 824) than in wild-type mice (1679 +/- 301), although the difference was not statistically significant (p = 0.0649) (Fig. 1B).
Gene_expression (expressing) of PDGF-BB associated with cancer
3) Confidence 0.67 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.97 Pain Relevance 0
are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-?
Gene_expression (produced) of PDGF-BB in vasculature
4) Confidence 0.67 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.62 Pain Relevance 0
Mice overexpressing wild-type human SNCA from the platelet-derived growth factor beta (PDGFb) promoter (line D PDGFb-SNCA) are reported to develop motor impairments in association with progressive loss of dopaminergic terminals [20].
Gene_expression (overexpressing) of PDGFb in platelet
5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 1.33 Pain Relevance 0.24
We selected this model (line D PDGFb-SNCA) which overexpresses wild-type human SNCA from the PDGFb promoter, in part, based on the fact that increased expression of wild-type SNCA in humans can cause PD, as demonstrated in families with autosomal dominant PD due to duplication or triplication of the normal (wild-type) SNCA gene [21], [22], [47], [48].
Gene_expression (overexpresses) of PDGFb associated with disease
6) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.58 Pain Relevance 0
Mice overexpressing wild-type human SNCA from the platelet-derived growth factor beta (PDGFb) promoter (line D PDGFb-SNCA) are reported to develop motor impairments in association with progressive loss of dopaminergic terminals [20].
Gene_expression (overexpressing) of PDGFb in platelet
7) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 1.32 Pain Relevance 0.24
We selected this model (line D PDGFb-SNCA) which overexpresses wild-type human SNCA from the PDGFb promoter, in part, based on the fact that increased expression of wild-type SNCA in humans can cause PD, as demonstrated in families with autosomal dominant PD due to duplication or triplication of the normal (wild-type) SNCA gene [21], [22], [47], [48].
Gene_expression (overexpresses) of PDGFb associated with disease
8) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.58 Pain Relevance 0
Among more than 50 known angiogenic factors (including matrix metalloproteinases, adhesion molecules, enzymes, and growth factors), we found that expression levels of PDGF-B, PDGF receptor ?
Gene_expression (expression) of PDGF-B associated with metalloproteinase and adhesions
9) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 1.23 Pain Relevance 0.24
B16 melanoma cells (1 × 106 mock-transfected or PDGF-BB expressing cells) were injected subcutaneously in 100 ?
Gene_expression (transfected) of PDGF-BB associated with experimental melanoma
10) Confidence 0.58 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.17 Pain Relevance 0.05
PDGF-BB is produced by most types of solid tumors, and PDGF receptor signaling participates in various processes, including autocrine stimulation of tumor cell growth, recruitment of tumor stroma fibroblasts, and stimulation of tumor angiogenesis.
Gene_expression (produced) of PDGF-BB in fibroblasts associated with cancer and solid tumor
11) Confidence 0.58 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.69 Pain Relevance 0
Furthermore, PDGF-BB-producing tumors are characterized by increased pericyte abundance and accelerated tumor growth.
Gene_expression (producing) of PDGF-BB in pericyte associated with cancer
12) Confidence 0.58 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2234427 Disease Relevance 0.93 Pain Relevance 0
SN GSH levels were higher in the NAC treated groups for both wild type and PDGFb-SNCA transgenic mice, but this increase only reached significance in the case of PDGFb-SNCA mice.
Gene_expression (transgenic mice) of PDGFb associated with targeted disruption and substantia nigra
13) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.49 Pain Relevance 0.26
However, since glutathione was transiently increased in the SN of NAC treated PDGFb-SNCA mice after 5–7 weeks of supplementation (but not after 1 year), we cannot completely exclude the possibility that even a transient rise in glutathione may have had lasting effects.
Gene_expression (treated) of PDGFb associated with substantia nigra
14) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.47 Pain Relevance 0.21
Mice overexpressing wild-type human SNCA from the platelet-derived growth factor beta (PDGFb) promoter (line D PDGFb-SNCA) are reported to develop motor impairments in association with progressive loss of dopaminergic terminals [20].
Gene_expression (overexpressing) of platelet-derived growth factor beta in platelet
15) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 1.32 Pain Relevance 0.24
Among more than 50 known angiogenic factors (including matrix metalloproteinases, adhesion molecules, enzymes, and growth factors), we found that expression levels of PDGF-B, PDGF receptor ?
Gene_expression (expression) of PDGF-B associated with metalloproteinase and adhesions
16) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 1.23 Pain Relevance 0.24
On the other hand, the number of vessels per high-power field in PDGF-BB-expressing tumors was decreased in wild type mice (p < 0.001) and D849N-mutant mice (p < 0.01) compared to wild type tumors (Fig. 1C).
Gene_expression (expressing) of PDGF-BB in vessels associated with cancer
17) Confidence 0.52 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.00 Pain Relevance 0
, independent of ectopic PDGF-BB expression, supporting earlier observations that this mutation causes significant receptor signaling in the absence of ligand, or greatly increases sensitivity towards very low amounts of ligand [15].
Gene_expression (expression) of PDGF-BB
18) Confidence 0.52 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.51 Pain Relevance 0
PDGF-BB expression increases tumor vascularization in wild type and D849N-mutant mice but has no further increasing effect on pericyte coverage in D849N-mutant mice
Gene_expression (expression) of PDGF-BB in pericyte associated with cancer
19) Confidence 0.52 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.85 Pain Relevance 0
PDGF-BB-expression significantly increased the pericyte density in B16 tumors (0.8–1.0 cm3) grown in wild type mice (p < 0.001) (Fig. 1D).
Gene_expression (expression) of PDGF-BB in pericyte associated with cancer
20) Confidence 0.52 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.92 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox