INT70886

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 12.57
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
platelet 6
aorta 4
brain 4
vessels 2
endometrium 2
Pdgfb (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 120 100.00 Very High Very High Very High
Angina 5 96.04 Very High Very High Very High
Dopamine 36 93.80 High High
Inflammation 68 85.44 High High
cva 4 66.76 Quite High
Inflammatory response 24 51.40 Quite High
ischemia 51 50.00 Quite Low
beta blocker 2 48.40 Quite Low
cytokine 15 36.00 Quite Low
fibrosis 6 25.20 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 183 99.98 Very High Very High Very High
Diabetes Mellitus 76 99.98 Very High Very High Very High
Brain Tumor 120 99.96 Very High Very High Very High
Disease 181 99.72 Very High Very High Very High
Hypertrophic Cardiomyopathy 5 99.48 Very High Very High Very High
Coronary Heart Disease 5 99.34 Very High Very High Very High
Hyperplasia 6 99.00 Very High Very High Very High
Cancer 362 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 77 98.16 Very High Very High Very High
Toxicity 48 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice overexpressing wild-type human SNCA from the platelet-derived growth factor beta (PDGFb) promoter (line D PDGFb-SNCA) are reported to develop motor impairments in association with progressive loss of dopaminergic terminals [20].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PDGFb in platelet
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 1.33 Pain Relevance 0.24
Mice overexpressing wild-type human SNCA from the platelet-derived growth factor beta (PDGFb) promoter (line D PDGFb-SNCA) are reported to develop motor impairments in association with progressive loss of dopaminergic terminals [20].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PDGFb in platelet
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 1.32 Pain Relevance 0.24
We selected this model (line D PDGFb-SNCA) which overexpresses wild-type human SNCA from the PDGFb promoter, in part, based on the fact that increased expression of wild-type SNCA in humans can cause PD, as demonstrated in families with autosomal dominant PD due to duplication or triplication of the normal (wild-type) SNCA gene [21], [22], [47], [48].
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of PDGFb associated with disease
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.58 Pain Relevance 0
We selected this model (line D PDGFb-SNCA) which overexpresses wild-type human SNCA from the PDGFb promoter, in part, based on the fact that increased expression of wild-type SNCA in humans can cause PD, as demonstrated in families with autosomal dominant PD due to duplication or triplication of the normal (wild-type) SNCA gene [21], [22], [47], [48].
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of PDGFb associated with disease
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.58 Pain Relevance 0
signaling due to transgenic overexpression of PDGF-B, or the D849N-mutant PDGFR-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF-B associated with targeted disruption
5) Confidence 0.40 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.98 Pain Relevance 0
The average vessel surface, defined as the total vessel area divided by the number of vessels, was increased in PDGF-BB-expressing compared to wild type B16 tumors, grown in wild type (p < 0.0001), as well as D849N-mutant mice (p < 0.01) (Fig. 1B).
Positive_regulation (increased) of Gene_expression (expressing) of PDGF-BB in vessels associated with cancer
6) Confidence 0.40 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.06 Pain Relevance 0
However, since glutathione was transiently increased in the SN of NAC treated PDGFb-SNCA mice after 5–7 weeks of supplementation (but not after 1 year), we cannot completely exclude the possibility that even a transient rise in glutathione may have had lasting effects.
Positive_regulation (increased) of Gene_expression (treated) of PDGFb associated with substantia nigra
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.48 Pain Relevance 0.22
Mice overexpressing wild-type human SNCA from the platelet-derived growth factor beta (PDGFb) promoter (line D PDGFb-SNCA) are reported to develop motor impairments in association with progressive loss of dopaminergic terminals [20].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of platelet-derived growth factor beta in platelet
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 1.32 Pain Relevance 0.24
In a recent report, transgenic mice were generated expressing PDGF-B in brain under control of the human GFAP promoter [32].
Positive_regulation (generated) of Gene_expression (expressing) of PDGF-B in brain associated with targeted disruption
9) Confidence 0.27 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.05 Pain Relevance 0
Furthermore, PDGF-B retrovirus-induced brain tumors developed at a higher frequency and with shorter latency when injections were performed in Trp53-null than in wild type mice, and in a Trp53-null background these tumors showed higher p-Akt and lower Pten levels [134].
Positive_regulation (induced) of Gene_expression (retrovirus) of PDGF-B in brain associated with cancer and brain tumor
10) Confidence 0.27 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.66 Pain Relevance 0
To investigate involvement of growth factors on myocardial hypertrophy in HCM patients, we evaluated gene expression and cellular localization of transforming growth factor-beta1 (TGF-beta1), insulin-like growth factors (IGF-I and IGF-II), and platelet-derived growth factor-B (PDGF-B) in ventricular biopsies obtained from patients with HCM (n=8), aortic stenosis (AS) (n=8), or stable angina (SA) (n=8) and from explanted hearts with ischemic cardiomyopathy (TM) (n=7).
Spec (investigate) Positive_regulation (evaluated) of Spec (investigate) Gene_expression (expression) of platelet-derived growth factor-B in hearts associated with angina, hypertrophic cardiomyopathy, cv unclassified under development and coronary heart disease
11) Confidence 0.11 Published 1997 Journal Circulation Section Abstract Doc Link 9264495 Disease Relevance 0.94 Pain Relevance 0.10
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
Positive_regulation (increase) of Gene_expression (expression) of PDGF
12) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.06
Upregulated production of angiogenic factors including PDGF, EGF, and VEGF have been described both in the mouse and human endometrium [55,56].
Positive_regulation (Upregulated) of Gene_expression (production) of PDGF in endometrium
13) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0
Irbesartan but not amlodipine treatment attenuated the development of atherosclerosis, collagen content, cellular proliferation, and macrophage infiltration as well as diabetes-induced AT-1 receptor, PDGF-B, MCP-1, and VCAM-1 overexpression in the aorta, despite similar blood pressure reductions by both treatments (Candido et al 2004).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF-B in aorta associated with diabetes mellitus, increased venous pressure under development and hyperplasia
14) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.98 Pain Relevance 0.04
Irbesartan but not amlodipine treatment attenuated the development of atherosclerosis, collagen content, cellular proliferation, and macrophage infiltration as well as diabetes-induced AT-1 receptor, PDGF-B, MCP-1, and VCAM-1 overexpression in the aorta, despite similar blood pressure reductions by both treatments (Candido et al 2004).
Positive_regulation (induced) of Gene_expression (overexpression) of PDGF-B in aorta associated with diabetes mellitus, increased venous pressure under development and hyperplasia
15) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.98 Pain Relevance 0.04

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