INT70893

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 6.13
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
Anatomy Link Frequency
hearts 2
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 83 99.28 Very High Very High Very High
Angina 1 94.48 High High
cINOD 1 80.88 Quite High
antagonist 4 76.16 Quite High
midbrain 20 68.76 Quite High
chemokine 2 62.88 Quite High
COX2 1 25.00 Low Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 8 99.68 Very High Very High Very High
Gastrointestinal Stromal Tumor 54 99.60 Very High Very High Very High
Hypertrophic Cardiomyopathy 5 99.48 Very High Very High Very High
Coronary Heart Disease 3 99.34 Very High Very High Very High
Leukemia 4 98.64 Very High Very High Very High
Adenocarcinoma 100 97.92 Very High Very High Very High
Cancer 168 97.80 Very High Very High Very High
Medulloblastoma 4 97.40 Very High Very High Very High
Cv Unclassified Under Development 1 96.00 Very High Very High Very High
Cv General 3 Under Development 1 94.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Searching via MEDLINE, PubMed, Gold Rush and article cross-referencing, we only found 4 other publications of NICTH in GIST; four of which had overexpression of "big" IGF II and in two there was overexpression of pro-IGF II [9-12].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF II associated with gastrointestinal stromal tumor
1) Confidence 0.67 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.89 Pain Relevance 0
Searching via MEDLINE, PubMed, Gold Rush and article cross-referencing, we only found 4 other publications of NICTH in GIST; four of which had overexpression of "big" IGF II and in two there was overexpression of pro-IGF II [9-12].
Positive_regulation (overexpression) of Gene_expression (overexpression) of pro-IGF II associated with gastrointestinal stromal tumor
2) Confidence 0.58 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.84 Pain Relevance 0
Corcoran et al. [29] recently noted that induction of IGF-2 expression in pre-malignant lesions coincides with progression to advanced medulloblastoma.
Positive_regulation (induction) of Gene_expression (expression) of IGF-2 associated with malignant neoplastic disease and medulloblastoma
3) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 1.41 Pain Relevance 0.04
A score of 0-5 was considered negative (IGF2BP3 and IGF-2 not overexpressed), and a score of 6 and higher was considered positive (overexpression of IGF2BP3 and IGF-2) in accordance with Koebel et al. [21].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-2
4) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.30 Pain Relevance 0
COX-2 mRNA and PGE2 levels are higher in proliferating cells compared with post-confluent differentiated cells and in cells that constitutively overexpress IGF-II.
Positive_regulation (overexpress) of Gene_expression (overexpress) of IGF-II
5) Confidence 0.46 Published 2000 Journal Oncogene Section Abstract Doc Link 11114729 Disease Relevance 0.38 Pain Relevance 0.08
However, IGF2BP3-mediated activation of IGF-2 translation has been shown to increase human leukemia cell proliferation [2].
Positive_regulation (activation) of Gene_expression (translation) of IGF-2 associated with leukemia
6) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 1.06 Pain Relevance 0
A score of 0-5 was considered negative (IGF2BP3 and IGF-2 not overexpressed), and a score of 6 and higher was considered positive (overexpression of IGF2BP3 and IGF-2) in accordance with Koebel et al. [21].
Neg (not) Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of IGF-2
7) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 0.31 Pain Relevance 0
In addition to IGF2, we found elevated expression of IGFBP4 in PA6-DA cells.
Positive_regulation (elevated) of Gene_expression (expression) of IGF2 associated with dopamine
8) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.23
To investigate involvement of growth factors on myocardial hypertrophy in HCM patients, we evaluated gene expression and cellular localization of transforming growth factor-beta1 (TGF-beta1), insulin-like growth factors (IGF-I and IGF-II), and platelet-derived growth factor-B (PDGF-B) in ventricular biopsies obtained from patients with HCM (n=8), aortic stenosis (AS) (n=8), or stable angina (SA) (n=8) and from explanted hearts with ischemic cardiomyopathy (TM) (n=7).
Spec (investigate) Positive_regulation (evaluated) of Spec (investigate) Gene_expression (expression) of IGF-II in hearts associated with angina, hypertrophic cardiomyopathy, cv unclassified under development and coronary heart disease
9) Confidence 0.03 Published 1997 Journal Circulation Section Abstract Doc Link 9264495 Disease Relevance 0.94 Pain Relevance 0.09

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