INT70895

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 8.98
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDGFB) cytoplasm (PDGFB)
Anatomy Link Frequency
platelet 3
SSV 2
fibroblasts 2
blood vessel 1
leucocytes 1
PDGFB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 99 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
c fibre 1 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
qutenza 1 99.16 Very High Very High Very High
Inflammation 78 97.80 Very High Very High Very High
fibrosis 77 96.80 Very High Very High Very High
Angina 1 96.36 Very High Very High Very High
chemokine 245 95.48 Very High Very High Very High
ischemia 25 87.88 High High
Disease Link Frequency Relevance Heat
Disease 36 100.00 Very High Very High Very High
Recurrence 13 99.84 Very High Very High Very High
Fibrosis 84 99.54 Very High Very High Very High
Coagulation Disorder 2 99.52 Very High Very High Very High
Cancer 197 99.12 Very High Very High Very High
Hypertrophic Cardiomyopathy 5 98.70 Very High Very High Very High
Coronary Heart Disease 3 98.56 Very High Very High Very High
Cv Unclassified Under Development 26 97.88 Very High Very High Very High
INFLAMMATION 91 97.80 Very High Very High Very High
Hepatitis B Virus Infection 10 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(PDGFb) and regulated on activation of normal T cell expressed and secreted (RANTES).
Localization (secreted) of PDGFb in T cell
1) Confidence 0.52 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.33 Pain Relevance 0.12
These results indicate that tissue penetration and specimen area are dependent on in vivo PDGF release rate.
Localization (release) of PDGF
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.10
However, the gene expression of CXCL1, 2, 5, and CCL21b induced by 25 µg PDGF coated on PLLA scaffolds (not encapsulated in PLGA microspheres) was not different from that by the empty scaffolds or 2.5 µg (low dose) PDGF microsphere groups, which suggests that PDGF release from PDGF-coated scaffolds may be too rapid to be effective.
Localization (release) of PDGF
3) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.06 Pain Relevance 0.27
By controlling the MW of the MS over a range of 6.5 KDa–64 KDa, release rates of PDGF can be regulated over periods of weeks to months in vitro.
Localization (release) of PDGF
4) Confidence 0.47 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.16 Pain Relevance 0.04
In addition, the results of blood vessel number and area also showed a similar relationship with in vivo PDGF release.
Localization (release) of PDGF in blood vessel
5) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.18
A sustained release of PDGF not only influences tissue neogenesis and neovascularization, but also impacts the PDGF-induced gene profile of chemokine family members, actin, and interleukins.
Localization (release) of PDGF associated with chemokine
6) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0.35
However, a major obstacle for its successful clinical application is the delivery system, which ultimately controls the in vivo release rate of PDGF.
Localization (release) of PDGF
7) Confidence 0.44 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.09 Pain Relevance 0.04
The radiation-induced secretion of PDGF has been assumed to derive solely from leucocytes.
Localization (secretion) of PDGF in leucocytes
8) Confidence 0.43 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.76 Pain Relevance 0.19
The secretion of PDGF could also be stimulated in irradiated stromal cells, such as endothelial and fibroblast cells [51].
Localization (secretion) of PDGF in fibroblast
9) Confidence 0.43 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.68 Pain Relevance 0.09
Thus, stromal cells, such as endothelial, fibroblasts cells, should be at least partially responsible for the release of cytokines, including PDGF.
Localization (release) of PDGF in fibroblasts associated with cytokine
10) Confidence 0.43 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.57 Pain Relevance 0.18
Gene expression profiles using cDNA microarrays were performed on the PDGF-releasing NFS.
Localization (releasing) of PDGF
11) Confidence 0.41 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.14 Pain Relevance 0.10
In order to investigate the effect of PDGF release rate on PDGF biological function in vivo, nine groups of 3 animals each were prepared to test in a rat wound healing model. [24] They were grouped as follows:
Spec (investigate) Localization (release) of PDGF associated with wound healing
12) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.10 Pain Relevance 0.13
Our group has previously shown that in vitro release rate of PDGF encapsulated in PLGA microspheres can be controlled by PLGA MW. [23] HMW PLGA microspheres containing PDGF take a longer time to be degraded and consequently release PDGF more slowly, and vice versa. [23] In the present study, PLGA MW shows an obvious relationship to the in vivo effects of PDGF encapsulated by PLGA on tissue neogenesis and vascularization.
Localization (release) of PDGF
13) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0
Moreover, inhibiting the PDGF pathway with neutralising antibodies to PDGF or administration of soluble extracellular region of PDGFR-?
Localization (region) of PDGF
14) Confidence 0.40 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.97 Pain Relevance 0.33
Data were prospectively collected for all patients undergoing EVLA for SSV disease in our unit, including clinical outcomes and postoperative duplex.
Localization (disease) of SSV in SSV associated with disease
15) Confidence 0.22 Published 2009 Journal Ann Vasc Surg Section Abstract Doc Link 18619773 Disease Relevance 0.54 Pain Relevance 0.07
During a median follow-up of 14 months (interquartile range 6-24) there was no clinical or duplex evidence of recurrence and no recanalization of the SSV.
Neg (no) Localization (recanalization) of SSV in SSV associated with recurrence
16) Confidence 0.21 Published 2009 Journal Ann Vasc Surg Section Abstract Doc Link 18619773 Disease Relevance 0.66 Pain Relevance 0.17
Secretoneurin (SN), a novel 33-amino acid neuropeptide derived from secretogranin II (chromogranin C), is widely distributed in the central and peripheral nervous and neuroendocrine systems, including afferent C-fibers, and can be <span style</span>="background-color:#B0E0E6">released in the periphery by capsaicin.
Localization (released) of PDGF associated with c fibre, qutenza and neuropeptide
17) Confidence 0.15 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351368 Disease Relevance 0.36 Pain Relevance 0.52
Platelet-derived growth factor is mainly secreted by the platelets’ ?
Localization (secreted) of Platelet-derived growth factor in platelets
18) Confidence 0.12 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.33 Pain Relevance 0.09
Platelets are the initiators of the clotting cascade, but they also release growth factors (including platelet-derived growth factor, PDGF) and cytokines to attract other cells required for healing.
Localization (release) of platelet-derived growth factor in platelet associated with coagulation disorder and cytokine
19) Confidence 0.12 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.66 Pain Relevance 0.14
ROS play also an important role in fibrogenesis throughout increasing platelet-derived growth factor [56] or the secretion of profibrotic cytokines, such as TGF-?.
Localization (secretion) of platelet-derived growth factor in platelet associated with fibrosis and cytokine
20) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.65 Pain Relevance 0.20

General Comments

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